Jonas Nikoloff Email & Phone Number

Germany

Stanford, California, United States

Using biochemical, cell biological and genome-wide screening approaches to understand the molecular basis of inherited Parkinson's Disease.

Basel, Switzerland

• Leading a team of scientific experts, associates, and students, coordinating projectrequests for pre-clinical studies in investigative immunosafety.• Lab management and maintenance of BSL2 tissue and organoid culture laboratories,contributing to automated workflows in new 360-Lab infrastructure.• Supporting the drug development against Inflammatory Bowel Diseases usingmicrofluidic in-vitro platforms.• Assay development for personalized immune therapy in pre-clinical studies to predictthe Cytokine Release Syndrome in cancer patients.

Basel Area, Switzerland

• Leading three studies on the release and distribution of diagnostic biomarkers inneurodegenerative diseases and cancer, combining single-molecule microscopy, andgene editing tools (CRISPR/Cas9); developing organ-on-a chip platforms to analyzehuman embryonic vasculature organoids and liquid biopsies.• In charge of biosafety for my team, implementing, realizing, and monitoring theregulatory compliance for a safe working environment.• Laser safety officer and imaging expert, conducting and coordinated the maintenanceand calibration of all optical systems.

Basel

Using quantitative widefield microscopy and high-dimensional singel-cell FACS to dissect lineage fate of hematopoietic stem cells.

Basel, Switzerland

• Establishing and optimising a novel mass-spectrometric method for assessing theContainer Closure Integrity of primary packaging at frozen conditions of lyophilizedproducts in GMP environments.• In charge of commissioning automated crimping devices for pharmaceutical primarypackaging under GLP, creating Standard Operating Procedures, providing training tosupervisors and technical staff.• Implementing analytical laser systems for particle detection under GLP.• Heading studies about product sterility and patient safety analyses of frozen activecompounds in aseptic environments.

Tianjin

• Mentoring an international team of scientists and students in GLP.• International project support and troubleshooting for protein engineering.• Supervising scientific communication and publishing processes.

Karlsruhe Und Umgebung, Deutschland

Protein-induced Crystallization Processes

Berlin, Germany

• Project support and administration within Quality Management/Microbiology of fourproduction lines for cardiovascular devices.• In charge of mammalian cell culture toxicity studies in the course of the audit log ofISO 10993-5.• Executing regular microbiological screenings and monitoring of four production linesfor continuous and online GMP clearance for the production of electrophysiologicalimplants.• Assisting and contributing to international audits of the Federal Health Organization

Education record

Doctor Of Philosophy - Phd, Biotechnology

Master Of Science (M.Sc.), Hematopoietic Stem Cells

Bachelor Of Science (B.Sc.), Applied Biology, 1.3

Thesis: "New Organic Compounds as Potential Inhibitors of ß-Catenin/TCF Driven Transcription"