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• Medicinal chemist who has contributed to both synthesis and design to help advance programs in different areas, including CNS and oncology.• Designed a variety of modalities, including covalent / noncovalent inhibitors and Proteolysis Targeting Chimeras (PROTACs).• Roles and responsibilities have included developing synthetic routes to complex novel targets, managing up to ten external chemistry FTEs, coordinating the preparation of experimental procedures and SAR tables for patent applications, proposing original design ideas, and acting as a lead synthetic chemist.• Passionate about applying molecular level thinking to mechanistically troubleshoot reactions and solve multiparameter optimization problems in design.
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Research Senior ScientistTakeda Aug 2024 - PresentTokyo, Jp -
Scientist IiTakeda Aug 2022 - PresentTokyo, Jp
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Scientist ITakeda Feb 2021 - PresentTokyo, Jp
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Scientist, Synthetic/Medicinal ChemistryAlkermes Sep 2018 - Feb 2021Dublin, Ie• Concurrently held leadership roles on two different projects: lead synthetic chemist (managing 7 external FTEs, beginning in April 2020) and manager of exploratory chemistry (2-5 FTEs, route-scoping and synthesis of tool compounds, June 2019-July 2020).• Leveraged SAR and conformational analysis to develop hypothesis-driven design proposals to improve permeability/efflux, metabolic stability, or solubility while retaining potency.• Designed efficient synthetic routes to diverse analogues in a fast-follow program based on Csp3-rich, multistereocenter-containing chemical matter.• Coordinated and led synthesis group meetings, engaging team members in discussions of synthetic challenges and opportunities. -
Graduate Research AssistantUniversity Of Illinois At Urbana-Champaign Jun 2013 - Aug 2018Champaign, Il, Us• Led a project on stereospecific Csp3 couplings of unactivated secondary alkylboronic acids.• Completed the optimized total synthesis of all four possible stereoisomers of the natural product xylarinic acid B.• Solved a multifactorial optimization problem (involving reaction yield, regiospecificity and enantiospecificity) by designing and synthesizing more than 20 novel phosphine ligands and designing an assay to rapidly test their effect on each reaction parameter.• Received the Vorhees Award for Best Original Research Proposal for proposing a novel strategy to eliminate the scale-limiting concentration-dependence of RCM macrocyclizations. -
Graduate Teaching AssistantUniversity Of Illinois At Urbana-Champaign Aug 2013 - Dec 2015Champaign, Il, Us* Taught undergraduate discussion sections (general chemistry, CHEM 102; organic chemistry, CHEM 332) and lab sections (organic chemistry, CHEM 233).* Planned and presented lessons on weekly basis.* Coordinated with fellow TAs to administer exams and lab assessments.
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Undergraduate ResearcherGrand Valley State University Jan 2011 - May 2013Allendale, Mi, Us* Synthesized chromene heterocycles en route to thyroid hormone derivatives.* Applied for and received funding from the Student Summer Scholars program.* Communicated results in written, poster, and presentation format.
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Jonathan Lehmann Education Details
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University Of Illinois Urbana-ChampaignOrganic Chemistry -
Drew UniversityResmed (Residential School On Medicinal Chemistry And Biology In Drug Discovery)
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Grand Valley State UniversityChemistry
Frequently Asked Questions about Jonathan Lehmann
What company does Jonathan Lehmann work for?
Jonathan Lehmann works for Takeda
What is Jonathan Lehmann's role at the current company?
Jonathan Lehmann's current role is Research Senior Scientist at Takeda.
What is Jonathan Lehmann's email address?
Jonathan Lehmann's email address is jo****@****mes.com
What is Jonathan Lehmann's direct phone number?
Jonathan Lehmann's direct phone number is +198960*****
What schools did Jonathan Lehmann attend?
Jonathan Lehmann attended University Of Illinois Urbana-Champaign, Drew University, Grand Valley State University.
What skills is Jonathan Lehmann known for?
Jonathan Lehmann has skills like Research, Organic Chemistry, Chemistry, Microsoft Powerpoint, Teaching, Microsoft Word.
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