1. Laquer V, Parra V, Lacour JP, Takahashi H, Knorr J, Okragly AJ, James DE, Sims JT, Chang CY, Chao J, Klekotka P. (2022) IL-33 antibody failed to demonstrate benefit in a phase 2 double-blind, randomised placebo-controlled study in adult patients with moderate-to-severe atopic dermatitis. Br J Dermatol. 2022 Apr 28. https://doi.org/10.1111/bjd.216312. Dörner T, Tanaka Y, Dow ER, Koch AE, Silk M, Ross Terres JA, Sims JT, Sun Z, de la Torre I, Petri M. (2022) Mechanism of action of baricitinib and identification of biomarkers and key immune pathways in patients with active systemic lupus erythematosus. Ann Rheum Dis. 2022 May 24:annrheumdis-2022-222335. https://doi.org/10.1136/annrheumdis-2022-2223353. Sims JT, Chang CY, Poorbaugh J, Daniels M, Beasley SL, Zhang L, Rodgers GH, Lena F, Lacerenza LG, Sposato B, Dupont A, Susen S, Casalini G, Corbellino M, Stebbing J, Krishnan V. (2022) Longitudinal assessment of systemic steroid therapy on hyperinflammatory endothelial biomarker profiles and serology responses of COVID-19 patients. J Transl Med. 2022 Sep 8;20(1):411. https://doi.org/10.1186/s12967-022-03583-54. Parthasarathy V, Cravero K, Deng J, Sun Z, Engle SM, Auxier AN, Hahn N, Sims JT, Okragly AJ, Alphonse MP, Kwatra SG. (2022) Circulating plasma IL-13 and periostin are dysregulated type 2 inflammatory biomarkers in prurigo nodularis: A cluster analysis. Front Med (Lausanne). 2022 Dec 6;9:1011142. https://doi.org/10.3389/fmed.2022.10111425. Ju T, Labib A, Nattkemper L, Engle S, Auxier A, Hahn N, Sissons S, Sims JT, Sun Z, Okragly AJ, Yosipovitch G. (2023) Serum Interleukin-13 and Caspase 8 are Elevated in Prurigo Nodularis. Acta Derm Venereol. 2023 Feb 7;103:adv00861. https://doi.org/10.2340/actadv.v103.4804

1. Zhou, J., Gemperline, D.C., Turner, M.J., Oldach, J., Molignano, J., Sims, J.T., Stayrook, K.R. (2021) Transcriptomic Analysis of Healthy and Atopic Dermatitis Samples Reveals the Role of IL-37 in Human Skin. ImmunoHorizons. 2021 Oct 26;5(10):830-843. https://doi.org/10.4049/immunohorizons.21000552. Engle, S.M., Chang, C.Y., Ulrich, B.J., Satterwhite, A., Hayes, T., Robling, K., Sissons, S.E., Schmitz, J., Tepper, R.S., Kaplan, M.H., Sims, J.T. (2021) Predictive biomarker modeling of pediatric atopic dermatitis severity based on longitudinal serum collections. Clinical & Experimental Immunology. Nov 30, 2021; uxab009, https://doi.org/10.1093/cei/uxab009.3. Sims JT, Poorbaugh J, Chang CY, Holzer TR, Zhang L, Engle SM, Beasley S, Doman TN, Naughton L, Higgs RE, Kallewaard N, Benschop RJ. (2022) Relationship between gene expression patterns from nasopharyngeal swabs and serum biomarkers in patients hospitalized with COVID-19, following treatment with the neutralizing monoclonal antibody bamlanivimab. J Transl Med. 2022 Mar 18;20(1):134. https://doi.org/10.1186/s12967-022-03345-3

1. Sims, JT, Krishnan, V, Chang, CY, Engle, SM, Casalini, G, Rodgers, GH, Nickoloff, BJ, Konrad, RJ, de Bono, S, Higgs, RE, Benschop, RJ, Ottaviani, S, Cardoso, A, Nirula, A, Corbellino, M, Stebbing, J (2020) Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19. J Allergy Clin Immunol. Sep 10 https://doi.org/10.1016/j.jaci.2020.08.0312. Sims, J.T., Chang, C.Y., Higgs, R.E., Liu, Y., Engle, S.M., Sissons, S.E., Rodgers, G.H., Simpson, E.L., Silverberg, J.I., Forman, S.B., Janes J.M., Colvin, S.C., Guttman-Yassky, E. (2021) Insights into adult atopic dermatitis heterogeneity derived from circulating biomarker profiling in patients with moderate-to-severe disease. Experimental Dermatology. 18 May https://doi.org/10.1111/exd.14389

Joint research position with the Biological Mass Spectrometry and Autoimmunity groups in the Tailored Therapeutics division of LRL. My work focused on the phosphoproteomic analysis of cytokine signaling pathways.

I studied the role of the Abelson family (c-Abl, Arg) non-receptor tyrosine kinases in breast cancer and melanoma progression in order to devise new therapeutic strategies for the treatment of highly metastatic forms of disease. ------1. Srinivasan, D., Sims, J.T., Plattner R. (2008) Deregulated Abl Kinases Promote Proliferation, Anchorage-Independent Growth and Survival of Aggressive Breast Cancer Cells. Oncogene, 14;27(8):1095-105. 2. Sims, J.T., and R. Plattner. (2009) MTT assays cannot be utilized to study the effects of STI571/Gleevec on the viability of solid tumor cell lines. Cancer Chemotherapy and Pharmacology, Aug;64(3):629-33. 3. Sims, J.T., Ganguly, S., Fiore, L, Holler, C., Park, E.S., Plattner, R. (2009) STI571 (Gleevec) sensitizes breast cancer cells to 5-Fluorouracil, Cisplatin, and Camptothecin in a cell type-specific manner. Biochemical Pharmacology, Aug 1;78(3):249-60.4. Zhao, H., Ou-Yang, F., Chen I., Hou, M., Yuan, S.F., Chang, H., Lee, Y., Plattner R., Waltz, S., Ho, S., Sims, J., Wang, S. (2010) Enhanced resistance to tamoxifen by the c-ABL proto-oncogene in breast cancer. Neoplasia, Mar;12(3):214-23.5. Ganguly, S., Fiore L.S., Sims, J.T., Friend, J.W., Srinivasan, D., Cibull, M.L., Wang, C., Novak, M., Kaetzel, D.M., Plattner, R. (2011) c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression. Oncogene, Sep 5.6. Sims JT, Ganguly SS, Bennett H, Friend JW, Tepe J, Plattner R. (2013) Imatinib reverses doxorubicin resistance by affecting activation of STAT3-dependent NF-κB and HSP27/p38/AKT pathways and by inhibiting ABCB1. PLoS One. 2013;8(1):e55509.

Studied the binding properties of Anaplasma phagocytophilum that promote infection of human neutrophils using a variety of molecular and microbiological techniques, cell culture, flow cytometry, and IFA. ------1. Reneer, D.V., Kearns, S.A., Yago, T., Sims, J., Cummings, R.D., McEver, R.P., Carlyon, J.A. (2006) Characterization of a sialic acid- and P-selectin glycoprotein ligand-1-independent adhesin activity in the granulocytotropic bacterium Anaplasma phagocytophilum. Cellular Microbiology, Dec;8(12):1972-842. Huang, B., Troese, M.J., Ye, S., Sims, J.T., Galloway, N.L., Borjesson, D., Carlyon, J.A. (2010) Anaplasma phagocytophilum APH1387 is expressed throughout bacterial intracellular development and localizes to the pathogen-occupied vacuolar membrane. Infect Immun, May;78(5):1864-73.3. Huang, B., Troese, M.J., Howe, D., Ye, S., Sims, J.T., Heinzen,R., Borjesson, D., Carlyon, J.A. (2010) Anaplasma phagocytophilum APH_0032 is expressed late during infection and localizes to the pathogen-occupied vacuolar membrane. Microb Pathog, Nov;49(5):273-84.

Purified and concentrated Salmonella-specific bacteriophage cultures and identified novel strains using Electron Microscopy (TEM). ------1. M. R. McLaughlin, M. F. Balaa, J. Sims and R. King. (2006) "Isolation of salmonella bacteriophages from swine effluent lagoons." J Environ Qual 35(2): 522-8. https://doi.org/10.2134/jeq2005.0080

Analyzed novel compounds synthesized through directed ortho-metalation of Dimethylarylamines using column chromatography and Gas Chromatography/Mass Spectrometry.

Extensively used cloning, sequencing, and PCR techniques to identify viral DNA & RNA via novel isolation/detection methods. ------1. Amy L Clem, Jonathan Sims, Sucheta Telang, John W Eaton and Jason Chesney. (2007) "Virus detection and identification using random multiplex (RT)-PCR with 3'-locked random primers." Virol J. Jun 28;4:65. https://doi.org/10.1186/1743-422X-4-65