I am a physician-scientist interested in translational and precision oncology. I am currently an Assistant Professor in the Division of Hematology/Oncology at UCSF. I take care of patients with advanced genitourinary cancers (including prostate, bladder, kidney and testicular cancers) and lead a research group studying prostate and bladder cancers.Our lab's research interests include understanding cancer metastasis and the tumor microenvironment, investigating mechanisms of therapeutic resistance, and identifying new synthetic lethal strategies using CRISPR-based technologies to better treat genitourinary malignancies. Our lab is particularly interested in molecular subtypes of advanced prostate cancer, including those characterized by mutations in CDK12. Current research projects including understanding the clinical characteristics and outcomes of CDK12-mutant prostate cancer (Reimers et al, Eur Urol, 2019), as well as understanding the biological functions of CDK12 (Wu et al, Cell, 2018) and developing strategies to target this subtype. In addition, we are investigating both old and new surface protein targets for cancer therapy (Chou et al, Can Res, 2022; Wang et al, Clin Can Res, 2021; Chou et al, Eur Urol Oncology, 2022; Chu et al, Clin Can Res, 2021)We welcome potential new lab members interested in completing a postdoctoral fellowship in the lab!