Jose Jorge Gorbea Colón, Ph.D. Email & Phone Number

Philadelphia, Pa, Us

Greater Philadelphia

As a member of the Insights & Analytics Team at Cofactor Group, I collaborate with pharmaceutical industry clients to provide data-driven insights that support the development and commercialization of new therapeutics. My role involves leveraging analytics, market research, and forecasting to help clients make informed decisions about their product portfolios, identify growth opportunities, and navigate the complex healthcare landscape.Key responsibilities:- Develop and maintain market forecast models for branded pharmaceuticals, incorporating a wide range of data sources and assumptions- Communicate data-driven insights, forecast results, and recommendations to clients and internal stakeholders- Conduct research to support business strategy, decision-making, and the development of accurate forecasts- Develop and implement analytics solutions that provide actionable insights and contribute to business performance- Work closely with cross-functional teams to support product development, launch, and lifecycle managementThrough my work, I aim to contribute to healthcare innovation and help improve patient outcomes. By leveraging my background in scientific research and growing expertise in data analytics and market forecasting, I strive to support our clients in achieving their goals and making a positive impact on the patients they serve.

Philadelphia, Pennsylvania

As an NSF Graduate Research Fellow, I advanced gene regulation and transcriptional initiation understanding through high-resolution Cryo-EM and integrative modeling. My key contribution was elucidating the structural organization of pre-initiation complexes on divergent promoters, culminating in a co-first author publication in Molecular Cell. This work unraveled transcriptional regulation mechanisms and shed light on a core structural aspect of gene activation.Beyond research, I leveraged my expertise in Cryo-EM and structural biology to mentor students and assist in teaching graduate-level courses, focusing on developing their analytical and critical thinking abilities.

Philadelphia, Pennsylvania, United States

As an IDEAL Research Fellow at the University of Pennsylvania, I focused on continuously fostering diversity and inclusion in academia. My role included mentoring students in the Summer Undergraduate Internship Program (SUIP), helping guide them along on their summer research journeys. Beyond mentoring, I played a key role in recruitment efforts, facilitated professional development panels, and collaborated with campus organizations to organize community events. These initiatives were pivotal in advancing IDEAL's mission to cultivate an inclusive and welcoming environment at the university.

Philadelphia, Pennsylvania, United States

As a Teaching Assistant for the Biochemistry and Biophysics Department's Cryo-EM Course (BMB634), I significantly contributed to educating advanced degree students in high-resolution Cryo-EM. My role encompassed developing and delivering lectures on single-particle analysis, offering personalized tutoring and feedback, and assessing student performance. I fostered a supportive learning environment, helped students grasp Cryo-EM's complexities, and mentored them in both classroom settings and on hands-on data analysis projects. This experience enhanced my teaching skills and allowed me to impact the education and mentorship of students in this cutting-edge field significantly.

Philadelphia, Pennsylvania, United States

During my rotation in Dr. John Karanicolas' Lab, I contributed to research on protein kinases' active sites using Rosetta's computational algorithms. My tasks included data analysis, interpretation, and the development of advanced computational methods. This work aimed to identify druggable pockets for virtual screening, potentially leading to new therapeutic agents. My lab experience enhanced my computational biology and structural analysis skills and fostered my ability to collaborate on complex research projects. Overall, this role was pivotal in developing my scientific career, allowing me to contribute significantly to research and skill advancement.

Philadelphia, Pennsylvania, United States

During my rotation in Dr. Ravi Radhakrishnan's Lab, I was part of a project focusing on the transactivation mechanisms of protein kinases like MEK, B-RAF, and C-RAF, crucial in skin cancer. Implementing molecular dynamics simulations for protein dimers, I contributed to preliminary insights into kinase activation mechanisms. This project was pivotal in deepening my understanding of cancer biology and molecular dynamics, fostering a growing interest in oncology and cancer research.

San Juan, Puerto Rico

As an NIH-BP ENDURE Fellow at the University of Puerto Rico, Rio Piedras Campus, I worked in Dr. Agosto's Lab on a project, in collaboration with Dr. Jorge Colón's lab, focused on the biocompatibility of Zirconium Phosphate nanoparticles for drug delivery and using sleep behavior in Drosophila melanogaster as a biomarker for drug tolerance. I developed assays to evaluate drug tolerance, assessed drug delivery effectiveness, and honed my data analysis and interdisciplinary collaboration skills. This experience enhanced my expertise in drug delivery systems and molecular biology research, contributing to advancements in novel drug delivery technologies with potential wide-ranging applications.

During my time as an NIH-RISE Undergraduate Research Fellow at the University of Puerto Rico, Rio Piedras Campus, in Dr. José Lasalde's Lab, I focused on purifying nicotinic acetylcholine receptors (nAChR) from Torpedo californica stingray electroplax tissues. This research aimed to elucidate nAChRs' structural properties via X-ray crystallography and their functional properties through single-channel recordings on lipid bilayers. I honed advanced protein purification techniques and delved into the structural and functional analysis of membrane proteins. Additionally, I mentored other undergraduates and engaged in collaborative projects. This experience enriched my skills in molecular biology and structural analysis, contributing to membrane protein biochemistry research, with implications for drug development and treating neurological conditions.

Philadelphia, Pennsylvania

During my internship at the University of Pennsylvania under Dr. Kim Sharp, I explored the molecular dynamics of proteins in reverse micelles through computational methods. I developed algorithms to study proteins' structural transitions within these systems. This work not only enhanced my skills in computational biology but also initiated a pioneering collaborative project between UPenn and UPR-Río Piedras, focusing on Alzheimer's Disease-related A-beta proteins. By encapsulating these proteins in reverse micelles, we aimed to understand the transitions leading to toxic oligomerization. This experience advanced my understanding of protein structure and dynamics, contributing to research on novel therapeutic approaches for protein-misfolding diseases like Alzheimer's Disease.

Fort Collins, Colorado Area

During my summer internship at Colorado State University-Fort Collins in Dr. Karolin Luger's laboratory, I focused on exploring the nucleosome assembly mechanism facilitated by the CAF-1 cofactor and its interaction with PCNA. I developed and executed biochemical assays to study CAF-1 and PCNA's roles in nucleosome assembly. This experience enriched my skills in protein purification and biochemical assay execution, along with fostering my ability to collaborate across disciplines and effectively communicate research findings. Working in Dr. Luger's Lab, I deepened my expertise in biochemistry and chromatin biology, contributing to research on nucleosome assembly mechanisms and their implications for developing therapies targeting chromatin-related diseases.

Fort Collins, Colorado Area

During my summer internship at Colorado State University-Fort Collins in Dr. A.S.N. Reddy's lab, I focused on studying the splicing regulation of serine/arginine-rich splicing regulatory proteins under drought stress in Sorghum bicolor. I was responsible for developing and implementing assays to analyze the drought stress impact on gene splicing regulation in this crop. This experience enriched my expertise in molecular biology assays and plant tissue handling. I also honed my skills in interdisciplinary collaboration and effectively communicated my research findings to varied audiences. Overall, this internship allowed me to advance my molecular biology skills and contribute to plant biology research, specifically understanding drought stress responses, potentially aiding in creating drought-resistant crops.

Natural Sciences Department

In Dr. Liz Diaz's laboratory, I served as an undergraduate research assistant focusing on the innovative use of local Puerto Rican algae for sustainable material production. Tasked with collecting and purifying algae for their silica content, our objective was to explore the feasibility of using this silica in creating ultralight insulating aerogels. My role encompassed establishing protocols for algae sample collection and purification, along with conducting assays to analyze the silica content. This experience not only enhanced my practical skills in wet-lab assays and the use of analytical instruments but also deepened my understanding of experimental biology and materials science. Contributing to the advancement of sustainable and environmentally friendly materials, our project aimed at offering novel solutions for the construction industry, emphasizing the potential of algae-based aerogels as insulating materials.

San Juan, Puerto Rico

During my internship at UPR-Río Piedras in Dr. Carlos Cabrera's laboratory, I worked on a project aimed at improving fuel cell efficiency by doping Pt cathodes with Cerium oxides. My responsibilities included developing protocols for the synthesis and characterization of these doped cathodes, as well as performing assays to assess their performance in fuel cell applications. This experience helped me gain practical skills in materials development for fuel cells, conducting wet-lab assays, and utilizing various analytical instruments. Our efforts contributed to the broader research on enhancing fuel cell technology. Overall, my time in Dr. Cabrera's lab allowed me to grow my technical abilities in experimental chemistry and materials science, supporting the pursuit of innovative materials for sustainable energy.

Plaza Las Américas

At Arte Arte, a traditional Puerto Rican art kiosk at Plaza Las Americas mall, my role as a cashier involved assisting customers, handling transactions, and keeping track of inventory. This job allowed me to learn about customer service, sales, and inventory management in a retail setting. Working there, I developed my ability to communicate and gained practical experience in a retail environment, while also contributing to the promotion of traditional Puerto Rican arts.

Doctor Of Philosophy - Phd, Biochemistry, Biophysics And Molecular Biology

Bachelor'S Degree, Molecular Biology

Activities and Societies: NIH-RISE Program Fellow NIH-ENDURE Program Fellow