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Immunologist and drug discovery scientist with 22 years of experience in inflammation research and cellular and mucosal biology. I enjoy the challenge of drug discovery and have initiated multiple early discovery research programs relevant to arthritis, asthma, inflammatory bowel disease, lupus, fibrotic disease, and cancer. I have the most experience advancing protein and antibody therapeutics, but have initiated small molecule and microbiome programs as well. These efforts have involved extensive in vitro and in vivo assay development and laying out clear plans for project progression and go/no-go decisions. More recently, my focus has been in translational research and biomarker leadership for clinical and early discovery programs.My key disease area of expertise is inflammatory bowel disease (IBD). I have defined a strategic vision for IBD research at two companies, initiated and enabled studies into multiple drug targets, and have identified and initiated various external collaborations to enable success in this disease area. I am a firm believer in using human genetic, functional, and clinical data to help define the most impactful targets for next generation IBD therapies. My current focus is in the celiac disease space where I am supporting two clinical programs and leading efforts to clarify use and implementation of histological endpoints in this indication.I have many years of experience in developing and troubleshooting in vivo models to study cell biology and immunology questions, as well as inflammatory disease. I do believe that in vivo studies can be useful, informative, and predictive, if used appropriately, and I am constantly looking for ways to improve my confidence in such models. Overall, I am a highly productive scientist with extensive leadership and management experience who enjoys the camaraderie within industry and the promise and challenge of finding safe and effective new drugs.
Takeda
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TakedaCambridge, Massachusetts, United States -
Director, Early Clinical Development, Translational Biomarker Lead, Gi-TauTakeda Aug 2023 - PresentTokyo, JpFully supporting Takeda clinical celiac disease programs, TAK-062 and TAK-101 as biomarker lead.Leading effort to assess CROs for ability to serve as a Phase 3 clinical trial vendor to support celiac histology. Reviewing capabilities for properly orienting and processing samples and developing methods for digital pathology scoring of samples to enable Vh:Cd, IEL count, and Marsh-Oberhuber scoring.Leading effort to evaluate the utility of different histology endpoints (quantitative and categorical) for use in celiac disease. This has yielded posters presented at ICDS, DDW, and UEGW meetings and content for briefing book submission to FDA. Manuscript is also in preparation. -
Associate Director, Translational Medicine & Biomarkers, Gi-DduTakeda Nov 2019 - Aug 2023Tokyo, JpDeveloped biomarker strategy and facilitated translational research for TAK-524 (preclinical microbiome program), TAK-018 (Phase 2 microbiome program) and TAK-062 (Phase 2 celiac program).Led translational research and biomarker ID for four early discovery IBD programs within the GI drug discovery unitManaged Senior Scientist within our group for one year as they onboarded. -
Ibd Program Director And Translational LeadFinch Therapeutics Group Aug 2017 - Nov 2019Led a diverse group of data scientists, microbiologists, and cellular/molecular biologists in a partnership with Takeda to develop FIN-524, a Rationally Selected Microbiota therapy for ulcerative colitis.IBD Program director 08/2017 - 11/2019Worked closely with a diverse research team that is screening bacteria in silico and in vitro to identify the consortium of bacteria predicted to produce the greatest clinical impactOverseeing process development manufacturing efforts with one of our partner CMOsManaging in vivo model execution through a collaborator to evaluate isolate and consortium properties Coordinating agendas and follow up for joint Finch-Takeda development and steering committeesContributing to Takeda stage gate documentation and slide preparation and FDA regulatory submissionsTranslational Lead 03/2019 - 11/2019Leading development of the translational strategy for FIN-524. Defining and prioritizing translational assays that will be used in clinical studies to understand engraftment, microbial PD, and host PD, as well as identifying the resourcing needed to qualify.Working with Data Science colleagues to define target dose recommendationsWorking with Finch and Takeda clinical and translational colleagues to define the clinical plan and success criteria
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Principal Research ScientistAbbvie Feb 2015 - Aug 2017Generated strategies for establishment of new biological expertise at AbbVie and identification of new targets for IBDLed a group of 5-10 scientists (research associates, PhD scientists, and one postdoctoral fellow) through two departmental reorganizations to establish in vitro and in vivo models in support of IBD strategyEarly discovery research group proposed or supported validation of more than 15 programs in support of go/no-go decisionsCore guidance team member for two external IBD collaborations of 3-5 year durationCore contributor to long-range planning strategies around biomarkers and IBD subphenotypesIdentified more than 7 academic or industry collaborations to enable advancement of department strategy or target validation
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Senior Scientist, Inflammation ResearchAmgen Mar 2009 - Dec 2014Thousand Oaks, Ca, UsInflammatory bowel disease research.Identification of new drug targets/development of new drug candidates for the treatment of inflammatory disease.Co-led IBD disease team, and significantly contributed to the development of IBD strategy, new target program initiation, and identification of collaboration opportunitiesLed an IBD task force which brought together various functional groups to discuss new ideas and emerging human data relevant to IBDRefined in vivo models of IBD for testing of therapeutic candidates, and developed methods for quantitating in vivo intestinal epithelial barrier function and bacterial persistenceManaged the development of in vitro intestinal organoid culture technology from mouse, rat, cynomolgus monkey, and human tissuesInitiated 2 protein, 1 antibody, and 2 small molecule projects within the early Inflammation Research pipeline, and performed in vivo work and validation for more than 3 potential external licensing opportunitiesManaged two senior technician direct reportsContributor to IACUC committee, operational efficiency committee, and planning of Amgen Seattle site-wide research celebration -
Scientist, Inflammation ResearchAmgen Dec 2005 - Mar 2009Thousand Oaks, Ca, UsInflammatory bowel disease research.Development of new drug candidates for the treatment of inflammatory disease.Initiated 1 protein and 1 Avimer project within the early Inflammation Research pipelineDeveloped in vivo models of colitis for testing of therapeutic candidatesManaged two direct reports -
Postdoctoral FellowUniversity Of Connecticut Health Center Oct 2001 - Dec 2005Farmington, Connecticut, UsInvestigated mechanisms by which lipopolysaccharide enhances antigen-specific T cell expansion and survival in vivoLinked the in vivo adjuvant activity of interleukin-18 on T cell responses to induction of OX40L on antigen presenting cellsCreated a transgenic model in which dendritic cells present a specific antigen to enable in vivo studies on the nature of T cell tolerance and immunity
Joseph Maxwell Skills
Joseph Maxwell Education Details
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Oregon State UniversityImmunology/Microbiology -
Oregon State UniversityBiochemistry/Biophysics
Frequently Asked Questions about Joseph Maxwell
What company does Joseph Maxwell work for?
Joseph Maxwell works for Takeda
What is Joseph Maxwell's role at the current company?
Joseph Maxwell's current role is Director, Early Clinical DevelopmentTranslational Biomarker Lead.
What is Joseph Maxwell's email address?
Joseph Maxwell's email address is jo****@****vie.com
What is Joseph Maxwell's direct phone number?
Joseph Maxwell's direct phone number is .800.255*****
What schools did Joseph Maxwell attend?
Joseph Maxwell attended Oregon State University, Oregon State University.
What are some of Joseph Maxwell's interests?
Joseph Maxwell has interest in Health.
What skills is Joseph Maxwell known for?
Joseph Maxwell has skills like Html5, Css, Photography, Digital Photography, Video Editing, Video, Social Media Marketing, Customer Service, Lightroom, Photoshop, Photo Editing, Social Media.
Who are Joseph Maxwell's colleagues?
Joseph Maxwell's colleagues are Anders Pode Milwertz, Jason Maust, Maria Lucrecia Scarinci, Bhagya V, Alvaro Venegas, Katsuhito Murase, Gwidon Wnuk.
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