Joseph Fackler Email and Phone Number
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I am currently the Director of Process Development-US at Adaptive Phage Therapeutics/BiomX (Gaithersburg, Maryland), an innovative clinical-stage company developing an effective therapeutic response to the global rise of multi-drug resistant (MDR) pathogenic bacteria.
Rise Therapeutics
View- Website:
- risetherapeutics.com
- Employees:
- 20
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Associate Director, Process Sciences And ManufacturingRise TherapeuticsUnited States
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Process Development ScientistRise TherapeuticsWashington, Dc, Us
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Director, Process Development UsAdaptive Phage Therapeutics/Biomx Inc Mar 2024 - Present• Led US team in upstream and downstream process development studies, providing technical, tactical, and scientific leadership• Designed and executed studies using Design of Experiment (DOE) approach for screening propagation conditions and growth media comparisons• Supervised setup of a parallel bioreactor system and performed pilot test runs with investigational product• Led Tangential Flow and Filtration (TFF) studies for purification of drug substance
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Head Of Process And Analytical DevelopmentAdaptive Phage Therapeutics Nov 2021 - Mar 2024Gaithersburg, Maryland, UsIn my role, I successfully managed three distinct groups/teams: Process and Analytical Team, Phage Hunting Laboratory (drug discovery), and Clinical Testing Laboratory.• Oversaw initial process scale up to Single Use Bioreactors (SUB) and led Tangential Flow and Filtration (TFF) optimization studies for a diverse group of phages and host bacterial species• Led development, optimization and qualification of analytical methods including: Viral Plaque Assay (VPA), LC-MS/MS platform for Host Cell Protein (HCP) and bacterial cell based Phage Susceptibility Tests (PST)• Directed establishment of a clinical testing laboratory to screen and match a subject’s isolate(s) for clinical trials -
Director Of ManufacturingAdaptive Phage Therapeutics Oct 2019 - Nov 2021Gaithersburg, Maryland, Us• Built and led a team of microbiologists/manufacturing technicians to manufacture batches of bacteriophage Drug Product for Phase II clinical trials• Supported batch disposition and batch release for multiple lots of Drug Product• Supported regulatory filings by authoring the CMC section of APT’s Master File• Participated in Type B meeting with the FDA as the CMC expert for APT's phage bank product
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Laboratory ManagerAdaptive Phage Therapeutics Apr 2018 - Oct 2019Gaithersburg, Maryland, Us• Led team of microbiologists/manufacturing technicians to manufacture bacterial cell and bacteriophage seed banks for Phase II UTI clinical trial• Screened, identified, and manufactured banks of drug product under GMP conditions for compassionate use cases• Managed external communications with public and private partners in support of compassionate use cases
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Senior MicrobiologistAdaptive Phage Therapeutics Dec 2017 - Oct 2019Gaithersburg, Maryland, Us• Collaborated with the US military partners to screen bacteriophages for activity against bacteria using Phage Susceptibility Test (PST)• Authored Standard Operating Procedures (SOPs) and batch production records to standardize manufacturing, reducing drug substance turnaround time by ~50%• Contributed to compassionate use cases by improving efficiency and effectiveness in drug development
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R&D MicrobiologistQ Laboratories, Inc. Nov 2016 - Dec 2017Cincinnati, Ohio, UsLead analyst in GLP/GMP compliant evaluations of antimicrobials and medical device reprocessing method validations. Experienced with BSL 2 microorganisms including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococci (VRE), Legionella spp. and Clostridium difficile endospores. Performed product and method validations on new molecular pathogen detection technologies. -
Staff Scientist/Field TechnicianPatriot Engineering And Environmental, Inc. Nov 2015 - Nov 2016Indianapolis, In, Us -
Adjunct InstructorUniversity Of Cincinnati Aug 2015 - Apr 2016Cincinnati, Ohio, UsInstructor for General Microbiology Laboratory, Microbiology for Health Professionals and Sophomore Genetic laboratory courses. Responsible for Laboratory instruction and supervision of laboratory techniques in microbiology, molecular biology and genetics such as: aseptic technique, isolation streaking, spread plating, environmental sampling, DNA isolation, transformation, PCR, Gel electrophoresis, bacterial identification, enzyme isolation and enzyme kinetics. -
Teaching AssistantUniversity Of Cincinnati Aug 2012 - Jul 2015Cincinnati, Ohio, UsInstructor for General Microbiology Laboratory and Microbiology for Health Professionals
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Lab TechnicianUniversity Of Cincinnati Jul 2011 - Aug 2012Cincinnati, Ohio, UsSupported laboratory staff by maintaining glassware, sterilizing laboratory materials and preparation of standard and specialized media.
Joseph Fackler Skills
Joseph Fackler Education Details
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University Of CincinnatiMicrobiology -
University Of CincinnatiBiology
Frequently Asked Questions about Joseph Fackler
What company does Joseph Fackler work for?
Joseph Fackler works for Rise Therapeutics
What is Joseph Fackler's role at the current company?
Joseph Fackler's current role is Associate Director, Process Sciences and Manufacturing.
What is Joseph Fackler's email address?
Joseph Fackler's email address is joseph.fackler@uc.edu
What schools did Joseph Fackler attend?
Joseph Fackler attended University Of Cincinnati, University Of Cincinnati.
What are some of Joseph Fackler's interests?
Joseph Fackler has interest in Science And Technology, Education.
What skills is Joseph Fackler known for?
Joseph Fackler has skills like Microbiology, Data Analysis, Pcr, Science, Molecular Biology, Research, Microsoft Office, Teaching, Viruses, Microscopy, Statistics, Molecular Genetics.
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