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• Scientific matrix leader of internal and external CRO scientists and scientific operations. Leading internal groups of 7-10 and 50+ external FTE, including daily chemistry, resource allocation and project and portfolio management.• Significant IT and operational experience as pertinent to scientific efficiency and IT rollout. demonstrating efficiency, data integrity, enhanced positive culture, increased performance, diversity and patient safety into early to late drug discovery.•Lead site user of keystone IT design software, LiveDesign. •Matrix group and project leader with demonstrated results leading high-profile chemistry discovery projects with exceptional team collaboration and communication skills in areas from immunology to antibacterials.• Medicinal chemist with significant industrial experience in the design, preparation and scale up of biologically active, small molecule drug candidates from the milligram to kilogram scale within advanced medicinal and combinatorial chemistry programs. • Application of innovative ways to speed up discovery programs through solutions including nimble cross-company collaborations in pre-candidate research and use of molecular design and chemoinformatic predictive tools. • Proven inventive track record as contributor to two marketed drugs and numerous clinical assets. Contribution to three >1kg GMP campaigns from medicinal chemistry lead molecules working closely with ChemDev, material science, radiochemistry, biology and formulation scientists, culminating in 16 publications and 22 patents.
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Scientific Leader, Global External Chemistry And Operations ManagerGsk Sep 2022 - PresentBrentford, Middlesex, Gb• A leader of global external medicinal chemistry groups (60-140 FTE), focusing on productivity, scientific excellence and communication between several external partners and internal project teams.• Operations leader in rollout of key IT packages, staff change management, metrics incorporation, KPI optimization and strategy innovation to gain cohesiveness in external and internal chemistry groups.• Project leader of discovery programs using external chemistry groups in antibacterial research.• Matrix group, series and project leader with demonstrated results leading high-profile chemistry discovery projects from H2L to candidate selection leading exceptional internal and external team collaborations. -
Site Lead User Of LivedesignGsk Mar 2022 - PresentBrentford, Middlesex, GbSite lead user of LiveDesign, a keystone cloud-based informatics application in the compound management, design and analytics of drug discovery. -
Scientific Leader, Medicinal ChemistryGsk Nov 2017 - Oct 2022Brentford, Middlesex, Gb• Series leader of high profile program from lead identification to multi-kg preparation of candidate molecules for advanced studies. Molecular identification to FTiH in just three years.• Highly experienced medicinal chemist, with key contribution to cutting-edge targets that have led to several candidates in the Immuno-inflammation therapeutic area.• Lead generation to scale up of lead compounds on multi gram scale, using cutting edge instrumentation, chemoinformatic tools, molecular modeling, IT tools of visualization and databases.• Experience with identifying, optimizing and bringing medicinal chemistry lead molecules to API in GMP preparation >1kg.• Chair, Chemistry Round Table, fostering excellence in departmental synthetic chemistry.• Group leader of internal and external chemists on high profile project including regular scientific presentation of project status.• Experienced direction of CRO chemists.• Selected as member of Chemistry Council, a committee charged with governance of company-wide chemistry culture, operations and scientific performance.• Adept at identifying IT solutions, user testing and problem solving of scientific and business-centered applications. -
Scale Up Team LeaderGsk Jan 2020 - Dec 2021Brentford, Middlesex, Gb• Fast Start Team leader of scale up chemists to mobilize API0, route remediation and bulk intermediate synthesis for project teams. Embedded member in projects to identify and propel leads into chemical development and incorporate into resourcing and portfolio decisions.• Demonstrated scale up leadership and lab contributions to multiple clinical candidates and lead optimization projects.• Incorporation of HTC, JLR, green chemistry and process safety into early medicinal chemistry routes for scale.• Routine collaboration and project management with Formulation, Material Science, Chemical Development, Pilot Plant and Biology group representatives. -
InvestigatorGsk Nov 2012 - Oct 2017Brentford, Middlesex, Gb• Lead generation to scale up of lead compounds on multi gram scale, using cutting edge instrumentation, IT tools of visualization and databases.• Design, synthesis and scale up of bioactive molecules, including targeting of PK, PD, physical properties improvement, formulation and prodrug strategies.• Leader in IT and operational duties around the lab, including design and relocation to an open lab and office format.• Business Representative for the construction of SMARTlabs for all chemists and biologists on site including floor plan, equipment, IT and logistics planning. -
Senior ScientistGsk May 2009 - Oct 2012Brentford, Middlesex, GbHit to lead investigation of several series of compounds in the inflammation area, including several scale ups for safety assessment. Method development for scale up of >100g of likely clinical candidate. Key contributor to current clinical candidate for RIP2. -
Research AssociateMerck Jan 2000 - Apr 2009Early drug discovery through preparation of material entering Phase 1 in the medicinal chemistry department. Projects include pain, Parkinson's disease and HCV including several clinical candidates. Key contribution in the design and synthesis of several compounds entering clinical development and beyond, including HCV NS3/4a protease inhibitors Vanihep (MK-7009, Vaniprevir, marketed in Japan), Zepatier (combination therapy with MK-5172, Grazoprevir as a marketed drug), and MK-1220 all for the treatment of hepatitis C, as well as NR2B antagonist MK-0657 (Phase I) for the treatment of pain and Parkinson’s disease.Experienced with mg to 15 kg scale preparation of intermediates and drug candidates.
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Associate ScientistAventis Pharma Jan 1999 - Dec 1999Paris, France, FrMedicinal chemist with emphasis on solution and solid phase combinatorial methods. -
Associate ScientistRhone-Poulenc Rorer 1999 - 1999Combinatorial Chemistry
Joseph Romano Skills
Joseph Romano Education Details
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Villanova UniversityOrganic Chemistry -
Ursinus CollegeChemistry -
Conestoga Senior High SchoolHigh School
Frequently Asked Questions about Joseph Romano
What company does Joseph Romano work for?
Joseph Romano works for Gsk
What is Joseph Romano's role at the current company?
Joseph Romano's current role is Scientific Leader at GSK Pharmaceuticals.
What is Joseph Romano's email address?
Joseph Romano's email address is jo****@****aol.com
What schools did Joseph Romano attend?
Joseph Romano attended Villanova University, Ursinus College, Conestoga Senior High School.
What are some of Joseph Romano's interests?
Joseph Romano has interest in Civil Rights And Social Action, Politics, Education, Environment, Science And Technology, Animal Welfare.
What skills is Joseph Romano known for?
Joseph Romano has skills like Medicinal Chemistry, Drug Discovery, Chemistry, Lead Optimization, Scifinder, Organic Chemistry, Clinical Research, Drug Design, Organic Synthesis, Lc Ms, Drug Development, Adme.
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