John Frost Email & Phone Number

New York, NY, US

Spring House, Pennsylvania, United States

Peptide Early Pipeline and Platform Team Lead

Kenilworth, New Jersey, United States

Led peptide drug discovery and optimization efforts for early-stage Immunology and Oncology programsInventing new peptide screening and synthesis platforms while mentoring and managing contractors and scientists to support drug discovery campaigns and validation of peptide screening initiatives

Kenilworth NJ

Medicinal Chemist focused on Peptide and Oligonucleotide drug discovery including synthesis, conjugation, purification, and optimizationCollaborated to developed a robust, high-throughput, peptide synthesis and purification platform Supported hit validation for 13 peptide-display screening campaignsInvented and published a new peptide cyclization approach

• Advisor: Prof. Andrei K. Yudin
• Developed and patented a new cyclization methodology to generate oxadiazole containing peptide macrocycles
• Characterized structural, conformational, and ADME properties of oxadiazole containing peptide macrocycles

• Thesis Title: Methods and Reagents for the Post-translational Cyclization of Genetically Encoded PolypeptidesAdvisor: Prof. Rudi Fasan
• Developed and patented new methodologies for macrocyclic peptide formation and chemoselective C-terminal protein labeling
• Designed and carried out scalable and divergent chemical synthesis
• Expressed, purified, and characterized bio-synthetic precursor proteins for peptide macrocyclization studies
• Isolated ribosomally derived macrocyclic peptides from complex cellular mixtures
• Conducted protein ligation reactions in living cells and in vitro; isolated and characterized the resulting products

• Formula Optimization GroupToppings and Icings Division
• Produced pilot plant samples of non-dairy toppings and icings, pudding, quiche, and beverage concentrates
• Operated, cleaned, and sterilized pilot plan equipment including homogenizer, Oakes continuous aerator, a scrape surface heat exchanger, and asceptic system
• Prepared lab samples and evaluated taste, texture, and stability of the final products

Project Title: Steric and Electronic Effects of Substituents on the Rates of Allene Cyclopropanation via Rhodium Catalysis

Post Doctoral Research Assistant, Chemistry

Doctor Of Philosophy (Ph.D.), Organic Chemistry

Master'S Degree, Organic Chemistry

B.S., Chemistry

Activities and Societies: American Chemical Society