Juliette Kahle Email & Phone Number

St Louis, Missouri, United States

St Louis, Missouri, United States

St Louis, Missouri, United States

Remote, Usa

* Classification of novel genetic variants identified in healthy patient populations for an expanded carrier screening NGS panel.* Gene-Disease investigation in collaboration with ClinGen.* Classification of novel genetic variants found in patients seeking inherited cancer testing (NGS panel).

Chapel Hill, Nc

Research Biologist in the Clinical Research Branch, Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development at the US Environmental Protection AgencyCLINICAL STUDIES:• Manage clinical studies including modifications of protocols, IRB submissions, consenting volunteer subjects, running daily study activities and managing clinical data and overall study progress.• Designed a workflow to access data… Show more Research Biologist in the Clinical Research Branch, Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development at the US Environmental Protection AgencyCLINICAL STUDIES:• Manage clinical studies including modifications of protocols, IRB submissions, consenting volunteer subjects, running daily study activities and managing clinical data and overall study progress.• Designed a workflow to access data from a medical software program in an exportable manner so that data can be extracted and used directly. The workflow resulted in reduced data entry-time (by approximately 75%) and increased accuracy.• Principal Investigator of a randomized, single-blind, two-arm crossover trial designed to identify interaction health effects of heat and ozone on healthy adult volunteers (completed).• Principal Investigator of a randomized, double-blind two-arm crossover trial designed to identify the way social factors impact on the health effects of ozone exposure in healthy adult volunteers (ongoing).• Co-investigator of a three additional clinical studies examining the role of epigenetics and multi-pollutant exposures in normal/healthy human responses to air pollutants (ongoing).• Co-investigator of a clinical study of the temporal alterations of the lung microbiome following burn and inhalation injury (ongoing). ANALYSIS AND LABORATORY BASED STUDIES• Lead investigator of plasma based microRNAs as biomarkers of exposure.• Developed a pipeline for microRNA analysis and cross-tissue comparison in multiple exposure paradigms using array and sequencing based approaches.• Use network analysis and pathway tools to gain insights into the functional relevance and molecular interactions of miRNAs and mRNA transcripts that are altered by toxicant exposure.• Mentor graduate students from UNC-Chapel Hill Curriculum in Toxicology Program. Show less

Duke Tip West, Durham, Nc

Designed the course and laboratory for an intensive summer program where I taught human and molecular genetics to gifted high school students at an academic residential camp.

Chicago, Il

Invited volunteer position serving as a molecular genetics expert for a large non-profit that was developing a policy on genetics and biotechnology. Collaborated with about 20 experts across disciplines including: medicine, agriculture, theology, environmental issues, law, public policy, biotechnology and others. Resulted in adoption of the policy by the 3.8 million member body in August 2011.

Houston, Texas

PhD candidate in Molecular and Human Genetics studying Spinocerebellar ataxias and protein-protein interactions in the laboratory of Dr. Huda Zoghbi.ANIMAL MODELS OF DISEASE• Used knock-in and knock-out mouse models to elucidate gene/protein function in spinocerebellar ataxias (SCA1, SCA6, SCA7).• Designed and implemented complex genetic mating schemes to gain insights into genetic interactions of mutant alleles at multiple loci in a tissue specific (Cre-driven)… Show more PhD candidate in Molecular and Human Genetics studying Spinocerebellar ataxias and protein-protein interactions in the laboratory of Dr. Huda Zoghbi.ANIMAL MODELS OF DISEASE• Used knock-in and knock-out mouse models to elucidate gene/protein function in spinocerebellar ataxias (SCA1, SCA6, SCA7).• Designed and implemented complex genetic mating schemes to gain insights into genetic interactions of mutant alleles at multiple loci in a tissue specific (Cre-driven) system.• Performed controlled mouse behavioral studies in home-cage and apparatus settings.• Designed high-throughput yeast-2-hybrid screen to elucidate protein-protein interactions relevant to neurodegeneration and macular degeneration.• Initiated a collaboration between two labs to understand the use of cross-tissue gene discovery in identifying novel molecular pathways. In particular I discovered that a gene involved in neurological disease is important in hematopoiesis. Show less

Clinical Laboratory Fellowship, Laboratory Genetics And Genomics (Abmgg)

Activities and Societies: Trainee Leadership Committee, Department of Pathology and Immunology (2019-2020); Clinical Pathology Trainee.

Doctor Of Philosophy (Ph.D.), Molecular And Human Genetics

Activities and Societies: Member of Graduate Student Council and Graduate Education Committee for Molecular and Human Genetics. Zoghbi.

Bachelor'S Degree, Biological Sciences, Honours

Activities and Societies: Worked in Student Housing Services as a Resident Assistant and Senior Resident Assistant from 2001-2003 (5.