Jun Zhong Email & Phone Number

Cambridge, Massachusetts, United States

Physiologically-based pharmacokinetics (PBPK) modeling for novel therapeutics, including gene therapy, cell therapy, and biologics

Cambridge, Massachusetts, United States

• Developed and executed translational PK/Efficacy modeling and simulation workflows for evaluating exposure response relationships of ADCs and informing clinical dosing strategies (e.g., dose escalation, and optimizing dosing frequency):1. Built PK/efficacy models to identify the PK driver of efficacy for ADCs in human xenograft bearing mice.2. Applied allometric scaling approaches to predict clinical PK using non-human primate (NHP) data.3. Utilized translational PK/efficacy modeling strategies to predict human exposure response relationships. 4. Performed model simulations to answer questions from internal clinical development stakeholders.• Evaluated PK/PD models to recapitulate the non-clinical exposure response relationship for multiple cytokines for an Immunosynthen STING agonist ADC. Supported FIH dose selection efforts using a minimum anticipated biological effect level (MABEL) approach by using translational PK/PD modeling to predict target receptor occupancy and support responses to regulatory agencies.• Established a non-clinical PK data analysis and reporting workflow to support programs across discovery and development, accelerating critical team decisions to drive programs forward:1. Co-authored a guidance document providing instructions and general best practices on performing NCA and interpretation of results for non-clinical PK data using Phoenix WinNonlin.2. Worked closely with bioanalytical scientists to streamline data organization and handling of a complex range of ADC related analytes using R apps. 3. Communicated PK/TK data analysis to cross-functional teams by authoring reports and summaries incorporating data visualization, interpretation, and presenting results to cross-functional teams. 4. Improved quality control and reduced turnaround times for delivering PK/TK topline results, enabling program teams to accelerate decisions for an expanding pipeline (e.g., bispecific mAbs, charge variants, novel small ADC payloads etc.)

Providence, Rhode Island, United States

Biological growth and instability of circular slender structures; Cell spreading and migration in mechanobiology; Constitutive modeling and damage mechanics of polymers

Blacksburg, Virginia, United States

Nonlinear dynamics, escape dynamics, and numerical computation in nonlinear structural mechanics

Blacksburg, Virginia, United States

Teaching assistant for undergraduate courses "Statics"

Changsha, Hunan, China

Nonlinear structural dynamics and numerical computation of composite beams, plates, and shells

Changsha, Hunan, China

Teaching assistant for undergraduate courses "Theoretical mechanics" and "Plates and shells"

Doctor Of Philosophy - Phd, Engineering Mechanics

Master Of Engineering - Meng, Solid Mechanics

Bachelor Of Engineering - Be, Engineering Mechanics