Junghoon Lee Email & Phone Number

Boston, MA, US

Hanover, New Hampshire, United States

• Project 1: Characterization of Stealth Liposome-Based Nanoparticles Encapsulating ACAT1/SOAT1 Inhibitor F26: Potential Therapeutics for Niemann-Pick Type C disease (NPCD)
• Engineered and optimized liposome-based nanoparticles for targeted delivery of small molecule inhibitors in a mouse model.
• Led pharmacokinetic (PK) and pharmacodynamic (PD) studies, demonstrating the efficacy of ACAT1 inhibitors in vivo.
• Conducted biochemical assays and histological assessments to evaluate biological and tissue-specific effects in treated Npc1 mutant mice.Project 2: The Functional Impact of Katnal2 in Neurodevelopmental Disorders.
• Investigated the role of autism spectrum disorder (ASD)-associated cytoskeletal genes in neurodevelopment by performing CRISPR-Cas9 mediated knockout of genes in murine neurons using retroviruses.
• Designed and executed an experimental strategy to identify the role of Katnal2 in ciliary microtubule dynamics within the brain, employing immunohistochemistry techniques.

• Conducted due diligence in innovative therapeutic areas through collaboration efforts with academic institutes.
• Performed competitive landscapes, regulatory considerations, and intellectual property (IP) search for cutting-edge technologies.
• Assisted with special projects, such as start-up company technology assessment, presentation, and IP portfolio management.

• Project: Development of Anti-cancer Drug through Inhibition of Tubulin Acetylation in Triple-negative Breast Cancer
• Performed high-throughput chemical screening on mouse embryonic fibroblasts (MEFs) to identify compounds targeting acetylated tubulin modifications.
• Utilized a chemical library of over 30,000 compounds to evaluate cellular morphology changes in MEFs, selecting 20 promising candidates for subsequent biochemical assays.

• Project: Development of Alzheimer’s disease (AD) Stage Monitoring Technology based on Multimodal Biometric Information
• Led a collaborative project with institutional hospitals to investigate AD-specific miRNAs in human subjects.
• Conducted microarray analyses to identify novel AD-related miRNAs in human subjects and Alzheimer’s disease mouse models, followed by functional studies in AD model cell lines using biochemical assays.

Doctor Of Philosophy - Phd, Biochemistry And Cell Biology

Master Of Science - Ms, Biology/Biological Sciences, General

M.S. School Of Life Science

Bachelor Of Science - Bs, Biology, General

B.S., Biology Concentration

Ph.D., Biochemistry And Cell Biology