Marek Kabat, Ph.D., D.Sc. Email and Phone Number
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Organic Chemist, Ph.D., D.Sc.• Pharmaceutical industry experience (20+ years), small molecules R&D and drug substance process development.• Experienced leader, manager, project representative, and coordinator. • Creative problem solver with excellent communication skills. • Experience with the scale-up process of drugs from bench-top via technology transfer to pilot plant.• Knowledgeable with contract development and manufacturing partners and with CRO/CMO organizations. • Effective manager of multiple projects.• Experience working in various environments, including research laboratory, kilo lab, and pilot scale facilities.• Analyze and summarize complex data sets. Prepare technical reports, publications, and oral presentations.• Proficient in organic chemistry and medicinal chemistry, including but not limited to asymmetric synthesis, fluorination, heterocyclic, natural products such as steroids, carbohydrates, C- and N-nucleosides, siRNA lipids, peptides, organometallic chemistry, and catalysis. • Authored publications in peer-reviewed journals, patents, speaker at domestic and international conferences. Additional Trainings and Certifications:• mini MBA. Rutgers University. Biopharma Innovation• Good Laboratory Practice (GLP). West Coast Quality Training Institute• Good Manufacture Practice (GMP). Jeiven Pharmaceutical Consulting• Foundation of Clinical Development. Mercer Institute of Management and Technology Trainings• Regulatory Affairs. Mercer Institute of Management and Technology Trainings• Clinical Quality Assurance (CQA). Mercer Institute of Management and Technology Trainings
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Director Process ChemistryNavitor Pharmaceuticals Jan 2022 - PresentCambridge, Ma, UsDirector of Process Chemistryo SME Consultant from October 2021-December 2021o Director of Process Chemistry till presento Advising and solving issues during GMP and non-GMP production of APIo Supporting projects development with design and optimization of the chemical manufacturing processeso Guiding process improvements, new chemical syntheses, batch investigations and deviationso Conveying new processes for API to meet COGS criteria.o Coordinating activities between various CDMOs (US, China, India, UK) and Navitoro Recommended and oversaw site selection, tech-transfer, scale-up, and ongoing manufacturing at CMO’so Issued RFP’s to CMO’s and evaluated CMO proposalso Assisted in-house patent attorney in providing guidance and developing IP strategies to benefit the businesso Conducted route optimization at external CMO’s to deliver non-GMP & GMP material on multi-kilogram scaleo Advised in purging studies of process impurities including genotoxic oneso Managing drug substance production of the major asset with CDMOso Interpreting data from internal efforts as well as our outsourcing partners and presenting results and outcomes to diverse audiences, including senior management
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Cmc ConsultatntInmagene Biopharmaceuticals Mar 2020 - Dec 2021San Diego, Ca, UsCMC Consultanto Remote consulting position for the Shanghai biotechnology companyo Overseeing API development of small molecule projects run by external CDMO in Tianjin, Chinao Transforming and redesigning MedChem synthetic route for drug substance scale up. o Chairing weekly meetings on API scale up with CDMO.o Navigating planning for timely API production for animal tox studies and GMP for human use.o Tracking, analyzing, and identifying impurities in API and recommending methods for its removal.o Reviewing and approving CDMOs production documents for fixed equipmento Consulting ad hoc issues related to API production. -
DirectorGsk Mar 2017 - Nov 2019Associate Director at the Platform Technology and Science Department• Leadership position at Platform Technology and Science (PTS) at GSK Shanghai. • Technical Lead responsible for metabolic markers and impurities (MMI) projects. • Technical Lead supporting Global API/ Global External Development & Supply (GEDS) team for outsourcing complex chemistry projects to CROs. • Technical guidance to chemists from R&D GSK Neuroscience projects in China.• Influenced the change at GSK of working with CRO’s to improve performance of projects.• Accountable for technical support of Global API/ GEDS team for outsourcing complex chemistry projects to CRO’s.• Liaise with PD&S / PTS China colleagues to ensure project risks and activities are integrated to mitigate the key development questions aligned to the stage of development for Neuroscience China R & D projects.• Reviewing and recommending Medicinal Chemistry projects for API production for Phase I and Phase II clinical trials.• Desiging novel synthetic routes and strategies, correcting and controlling CRO routes for API production.• Contributing to CMC section of regulatory documents.
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Executive DirectorPharmaron, Beijing, China May 2014 - Jun 2015Executive Director at the Chemistry Manufacturing and Controls Department• Reviewing incoming projects from US pharmaceutical and biotechnology clients, advising FTEs or Pay-for-Service.• Preparing and negotiating price quotations, timelines, and allocation of resources.• Simultaneously managing several projects (8-10) to delivere agreeable quantity and quality of products.• Designing chemical processes to achieve scalability from grams (laboratory) to hundred kilograms (pilot plant); focusing on yields, purity, and feasibility.• Supporting manufacturing operations, scheduling, logistics, batch records. • Communicating projects progress with US clients (Gilead, Roche, Merck) by weekly reports, TCs, personal contacts. Authoring technical documentation: development reports, technology transfer packages, final reports. • Accountable for about 30 chemists (PhD, MSc, BS, technicians).
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Sr. Principal ScientistHoffmann-Laroche Inc. Nutley. Nj 07110. Usa 1993 - Dec 2013Switzerland 🇨🇭 , ChSenior Principal Scientist at the Chemical Synthesis Department• Creating and executing processes that allowed the Kilo Laboratory and the Pilot Plant to meet project timelines. Managing multi-step syntheses at both small scale (lab) and large one (kilo lab and plant). • Developing alternative, more efficient and cost effective, novel synthetic routes/strategies for the manufacture of large quantities of bulk drug substances. • Coordinating activities in the Kilo Laboratory, ensuring that scale-up issues were quickly addressed with no delay in development programs. • Project representative and coordinator delegated from the Chemical Synthesis Department at the Roche-Nutley Project Team on various approved development projects. • Interacting with teams of scientists from medicinal, computational, drug safety, drug formulation, and CMC in the development of clinical candidates. • Developing several new methodologies applicable for scale up technologies and published articles and review articles in per-review journals. • Writing numerous internal project reports (e.g., Method Report, Progress Reports) and contributing to technology transfer for Phase I and Phase II development. • Supervising junior scientists and PhDs in specific projects. • Experienced in labeling of chemical molecules with stable isotopes (2H, 13C) and radioisotopes (3H, 14C). -
Sr. ScientistHafslund-Nycomed. Oslo. Norway 1992 - 1993• Teamed up with international team scientists in developing a peptide program with hemoregulatory activity.• Developed a process for orthogonally functionalizing optically active aminoglutamic acid for the synthesis of several dimeric peptides.
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PostdocSloan-Kettering Instsitute For Cancer Reserach. New York. Ny. Usa 1985 - 1986New York, Ny, UsAdvisor: Dr. Kyoichi A. Watanabe• Developed methodology for the synthesis of C-nucleosides from ribonolactone, hus allowing the synthesis of a novel series of isosteric and isoelectronic analogs of nicotinamide nucleoside and several ribofuranosyl picolinamides
Marek Kabat, Ph.D., D.Sc. Skills
Marek Kabat, Ph.D., D.Sc. Education Details
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Institute Of Organic Chemistry. Polish Academy Of Sciences. Warsaw. PolandOrganic Chemistry -
University Of WarsawChemistry
Frequently Asked Questions about Marek Kabat, Ph.D., D.Sc.
What company does Marek Kabat, Ph.D., D.Sc. work for?
Marek Kabat, Ph.D., D.Sc. works for Navitor Pharmaceuticals
What is Marek Kabat, Ph.D., D.Sc.'s role at the current company?
Marek Kabat, Ph.D., D.Sc.'s current role is Director at Navitor Pharmaceuticals.
What is Marek Kabat, Ph.D., D.Sc.'s email address?
Marek Kabat, Ph.D., D.Sc.'s email address is ma****@****gsk.com
What is Marek Kabat, Ph.D., D.Sc.'s direct phone number?
Marek Kabat, Ph.D., D.Sc.'s direct phone number is +44 20 8047*****
What schools did Marek Kabat, Ph.D., D.Sc. attend?
Marek Kabat, Ph.D., D.Sc. attended Institute Of Organic Chemistry. Polish Academy Of Sciences. Warsaw. Poland, University Of Warsaw.
What skills is Marek Kabat, Ph.D., D.Sc. known for?
Marek Kabat, Ph.D., D.Sc. has skills like Organic Chemistry, Medicinal Chemistry, Drug Discovery, Chemistry, Drug Design, Organic Synthesis, Glp, Synthetic Organic Chemistry, Heterocyclic Chemistry, Drug Development, Lc Ms, Peptides.
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