Developing nucleic acid therapeutics and sensors delivered using lipid nanoparticlesDepartment of Biomedical Engineering - OFK Lab: https://ofklab.com/

Developed pullulan based thin films for the oral delivery of mRNA lipid nanoparticles (LNPs) and characterized enzyme activity within thin film formulations in the Adronov Research Group (ARG). Partnered with Rapid Dose Therapeutics and Acuitas Therapeutics.• Optimized the thin film formulation to optimize the stability of mRNA LNPs and enzymes• Synthesized thin films following the solvent casting method• Conducted various biochemical assays to characterize enzyme activity and RNA integrity• Synthesized LNPs following the ultrasonication method and the solvent emulsification method to encapsulate active ingredients• Characterized LNPs polydispersity and structural integrity• Analyzed encapsulation efficiency of LNPs• Prepared PowerPoint slides for team meetings discussing results and future steps

Developed binding domains on bi-specific small molecules for cancer immunotherapy• Computationally modeled over 500 peptide sequences, secondary structures, and their biomolecular interactions with CD64 and CD16• Synthesized peptides using solid phase peptide synthesizer• Conducted click reaction to conjugate synthesized peptide with biotin• Purified and characterized peptides using HPLC and LC-MS• Analyzed the binding affinity of peptides to CD64 and CD16 using biolayer interferometry

As the Director of Research for the Future Einsteins, I ...• Organized and lead weekly meetings to discuss progress and future operations with dozens of volunteers • Prepared presentations bi-weekly to update the progress of the research committee and the operations of in-person summer camps• Coordinated the recruitment of volunteers for the research committee and delegated tasks weekly• Revised 2-3 scientific blog articles weekly and issued >100 articles since September 2019

• Wrote articles for The Future Einsteins scientific blog • Created and edited scientific educational lessons for elementary/middle school students• Gathered credible data and information from academic articles

• Investigated genetics and psychological trends with relation to COVID-19 with a team of 5 undergraduate and graduate students, lead by Dr. Brad Bass• Designed research methodology which involved the collection of data from 240 participants across Canada• Conducted literature reviews on 50+ academic journal articles• Attended bi-weekly meetings to discuss findings

• Consistently performed error-free work on over 1000 electronic products• Soldered and assembled electronic thermostats and LED clocks