Karthik Chandu Email & Phone Number

Ann Arbor, MI, US

Ann Arbor, Michigan, United States

• Developed, validated, and optimized diverse analytical methods (LC-MS, LC-DAD, LC-ELSD, GC-FID, GC-MS) for small molecules, peptides, proteins, bio-conjugates and gene therapy products.
• Led stability program and managed lot release testing, performing and overseeing a variety of assays.
• Mentored team members in experiment planning and troubleshooting.
• Conducted peptide mapping and host cell protein analysis using bottom-up proteomics, identifying immunogenic proteins in gene therapy products.
• Analyzed and determined process intermediate contaminants using mass spectral analysis.
• Developed and validated high-resolution LC-MS methods for precise chemical characterization and confirmation of monomers and dimers.

Ann Arbor, Michigan, United States

Lead on Stability program for biotherapeutics- Planning, assigning work and execution of variety of assays for stability programLCMS method development- Proteins and peptides biotherapeutics using bottom-up proteomics and software applications such as mascot and skyline- Determination of conjugation efficiency in peptide bioconjugatesClearance assays for.

Ann Arbor, Michigan, United States

Lead on Stability program for biotherapeutics- Planning, assigning work and execution of variety of assays for stability programLCMS method development- Proteins and peptides biotherapeutics using bottom-up proteomics and software applications such as mascot and skyline- Determination of conjugation efficiency in peptide bioconjugatesClearance assays for.

Cleveland, Ohio

• Taught general chemistry and organic chemistry labs with 48 students each semester
• Analysis of synthesized organic products with Benchtop NMR: Magritek, GC-TCD: Perkin Elmer, FTIR

Cleveland/Akron, Ohio Area

• Developed and validated LC-MS/MS methods for quantitation of dynorphin peptides with 800 times better sensitivity than any published LC-MS methods using bottom-up proteomics
• Developed and validated LC-MS/MS methods for proteins and small molecule quantification
• Hands-on experience with single quadrupole (Shimadzu), triple quadrupole (SCIEX), Q-TOF mass analyzers (AB).
• Hands-on experience on Gas Chromatography-Mass Spectrometry (GC-MS - Agilent) and GC-TCD (Perkin Elmer)
• Worked on gradient chromatofocusing separation of proteoforms (LC-UV: Shimadzu and Beckman Coulter)
• Experienced in analyzing synthesized organic compounds using bench-top NMR (Magritek), FTIR (PerkinElmer)

Hyderabad Area, India

• Worked on the evaluation of solid dosage forms - In vitro characterization - Hardness testing - Weight uniformity - Particle size distribution

Mallapur, Hyderabad

• Worked on master’s thesis research on “The formulation and evaluation of Acetazolamide loaded modified-release ocular thin films of chitosan.” gaining hands-on experience
• Formulated the ocular films
• Evaluated the films for flexibility, uniformity (weight, thickness), drug content.

Hyderabad Area, India

• “Attenuation of acute and chronic restraint stress-induced perturbations in experimental animals by Zingiber officinale roscoe”
• Gained hands-on experience with Ultraviolet absorption measurements and standard graphs

Doctor Of Philosophy (Phd), Bioanalytical Chemistry, 3.89

Activities and Societies: • Vice president for the Graduate Student Interdisciplinary Research Committee • Member of American Society for.

Master'S, Pharmaceutics, 3.8

Activities and Societies: • Represented pharmacy graduate students and acted as a link to communicate pharmacy graduate student issues and.

Bachelor'S Degree, Pharmacy, 3.6

Graduated Bachelors in Pharmacy with majors in Analytical Chemistry, Pharmaceutics, and Pharmacokinetics.

High School, Sciences And Mathematics, 3.6

Activities and Societies: • Member of Junior Red Cross (2011-2013) • Captain of the white house group in tenth grade (2012-2013) •.