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Motivated immunologist and in vivo scientist with 10 years of experience and strong technical expertise in the therapeutic areas of immuno-oncology, cancer biology, inflammation, and virology; love of discovery, problem solving, scientific communication, collaboration, and learning new things wit:h proficiency in• Discovery, pre-clinical, translational, and phase 1 stages of drug development• Establishing and managing projects with contract research organizations (CRO) and external collaborators• in vivo and in vitro screening and candidate nomination for new therapies, including T cell-based therapies and immune-modulatory protein-based molecules• Design and carry out efficacy, pharmacodynamic (PD)/pharmacokinetic (PK), and mechanistic studies of candidate therapeutics • Experimentation, documentation, quality control (QC) for initial new drug (IND) and intellectual property (IP) filing• Collaborating with translational and clinical teams for appropriate indication, dosage amount and route, and biomarker determination for therapeutics • Development of PK and PD assays for clinical trial studies • Presentation of team efforts to internal audiences, as well as externally, including conference talks and posters and manuscripts
Clasp Therapeutics
View- Website:
- clasptx.com
- Employees:
- 50
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Clasp TherapeuticsCambridge, Ma, Us
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Senior Scientist, ImmunologyClasp Therapeutics May 2023 - Present
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Senior Scientist, Pre-Clinical SciencesJounce Therapeutics, Inc. Jul 2022 - Mar 2023Cambridge, Ma, Us• Worked across project teams to support preclinical in vivo efforts for all company programs.• Served as in vivo representative for programs in discovery and candidate nomination stages, helping to move molecules through nomination process. • Determined go/no-go decision for candidate programs.• Performed mouse model studies including biodistribution, target engagement, PK analysis, and PD studies. • Developed protocol for in-life image-based biodistribution of fluorescently labeled antibodies and trained team members.• Interfaced with outside vendors to obtain appropriate humanized transgenic and knock-in mouse models for discovery and preclinical studies. -
Senior ScientistRepertoire Immune Medicines Jun 2019 - Apr 2022Cambridge, Ma, Us• Performed in vivo mouse studies and in vitro assay development for T cell- and cell-targeted cytokine fusion protein-based immune therapies that led to candidate nomination.• Employed study results for IND-enabling, IP filing, and manuscript preparation.• Utilized available literature and sequencing databases to determine mechanism of action and predictive biomarkers for cytokine-based therapeutics.• Developed and managed project timelines and budgets; supervised and mentored a research associate.• Collaborated in cross-functional teams, including product development, clinical biomarkers, competitive intelligence, and facilities management. -
Senior ScientistTorque Jun 2019 - Mar 2020
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Postdoctoral FellowUniversity Of Pennsylvania Jul 2015 - Jun 2019Philadelphia, Pa, Us• Examined the role of tumor suppressor protein p53 in tumor immune surveillance. • Utilized genetically engineered mouse models to investigate the role of the immune system in p53-mediated tumor regression. • Studied roles of NK cells, neutrophils, macrophages, and monocytes in tumor microenvironment, as well as the interaction between these cell subsets.• Supervised and trained graduate and rotation students. • Maintained and trained users on flow machine for entire department. -
Postdoctoral ResearcherSt. Jude Children'S Research Hospital Sep 2013 - Apr 2015Memphis, Tn, Us• Used various knockout mice to characterize the T cell response to flu including whole mouse and bone marrow-derived primary immune cells. Volunteered in science education in the Memphis community. -
Phd CandidateEmory University Sep 2007 - Aug 2013Atlanta, Ga, UsPrinciple Investigator: Martin Moore, PhDDefining Virulence Mechanisms of Respiratory Syncytial VirusMy research focuses on a BALB/c mouse model of respiratory syncytial virus (RSV), specifically the causes of increased pathogenesis and mucus production and the role of the immune system in these processes. To model severe RSV infection, I use a recently isolated clinical strain called A2001/2-20, which results in increased disease severity, marked by mucus production, increased weight loss, and increased breathing effort. My research focuses on the following areas: 1) The role of the A2001/2-20 fusion (f) protein in mucus production and increased pathogenesis. 2) The role of neutrophils in mucus production during RSV infection. -
Biochemistry And Cell Biology Concepts Teaching AssistantEmory University Aug 2012 - Dec 2012Atlanta, Ga, UsI worked as a teaching assistant in this foundation class that is taken by most first year biological sciences graduate students at Emory University. I prepared a 10 minute concept talk once a week to highlight information learned in lectures and wrote and graded open-ended question-based tests.
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Laboratory TechnicianCenter For Advanced Biotechnology And Medicine Oct 2005 - Aug 2007
Kate Stokes Skills
Kate Stokes Education Details
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Emory UniversityImmunology And Molecular -
Rutgers UniversityBiotechnology; Microbial Technology
Frequently Asked Questions about Kate Stokes
What company does Kate Stokes work for?
Kate Stokes works for Clasp Therapeutics
What is Kate Stokes's role at the current company?
Kate Stokes's current role is Experienced and motivated immunologist.
What is Kate Stokes's email address?
Kate Stokes's email address is ks****@****ire.com
What is Kate Stokes's direct phone number?
Kate Stokes's direct phone number is +160992*****
What schools did Kate Stokes attend?
Kate Stokes attended Emory University, Rutgers University.
What are some of Kate Stokes's interests?
Kate Stokes has interest in Hiking, Brewing Beer, Running, Cooking.
What skills is Kate Stokes known for?
Kate Stokes has skills like Molecular Biology, Cell Culture, Tissue Culture, Flow Cytometry, Elisa, Western Blotting, Protein Chemistry, Immunohistochemistry, Fluorescence Microscopy, Pcr, Mouse Models, Research.
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