Kate W. Email & Phone Number

Zurich, Switzerland

Zurich, Switzerland

LC-MS method development and applications, analysis of metabolomic and lipidomic dataDevelopment and validation of custom semi-targeted HILIC method for central carbon metabolism (plasma, urine, tissue, cell extracts)Swiss Multiomics Center metabolomics facility manager: sample handling, processing, data acquisition and analysis, metabolite IDSupervision of Master students, undergraduate teaching for metabolomics and mass spectrometry lectures (“Systems Biology”)

Basel, Switzerland

Based in the DACH area, serving LC-HR-MS customers from pre-sales to post-installation. Training, troubleshooting and support for method development and data analysis applications across biopharma applications, metabolomics, lipidomics and proteomics business areas

Basel, Switzerland

Investigating mechanisms of air pollution toxicity, primarily using targeted and untargeted LC-MS and integrated statistical data analysis of acellular chemical assays, metabolomics, lipidomics and metadata. I am interested in the composition, reactivity and toxicology of particulate matter, and the biological and epidemiological effects these compounds exert. Statistical analysis of real-world atmospheric aerosols data, Development of computational tools for analysis and visualisation of untargeted Orbitrap LC-MS and MS/MS dataCollation of small molecule database of atmospheric-and pollution-specific compoundsLC-MS analysis of atmospheric aerosols and their mechanisms of formation and biological toxicity. Targeted and untargeted analysis with quantification and structural elucidation (MS/MS, NMR)Investigating formation of highly oxygenated secondary organic aerosols using both synthetic methods and analytical characterisation of filter samplesSupervision of PhD/masters students, academic mass spectrometry laboratory management

London, England, United Kingdom

Statistical analysis planning and exploratory data analysis of unstructured biological data, statistical analysis of clinical studies, for researchers, clinicians and technical staffConversion, binning and peak selection for raw LC-MS and NMR metabolomics data, feature extraction, data manipulation, cleanup and data QC (drift, mass and batch correction)Integration of multiple data types including immunology, metagenomics, metabolomics, clinical metadata, and clinical assay data for stratification of patient groups and outcome predictionStatistical analysis of large cohort clinical liver disease study (Gut-Liver Axis study), selection and execution of appropriate statistical tests, multiple comparisons adjustments, clustering and classification, power calculations, biomarker selectionTranslational biomarker development: metabolite ID for 300+ features of interest, random forest variable selection to obtain optimized 10-compound biomarker panel of 90-day liver patient survival and disease stratification (validated with second data acquisition)

London, England, United Kingdom

Integration of metabolomics data for multivariate modelling: investigation and application of PLS/PCA modelling of NMR, LCMS and SNP dataSimulating classification and feature recovery in sparse PLS models using electronic spiking method with design of experiments to assess signal variability, biological effect size, and loadings proximity by Euclidean distances and HCA to assess loadings behaviour and determine optimal biomarker patterns in relation to non-correlated data, for automated selection of features of interest in megavariate ‘omics dataValidation with multi-cohort cardiovascular epidemiological study, to improve patient stratification and biomarker identification. Produced multivariate models with cross-validation and permutation testing of clinical metadata and genomics data (SNPs) for NMR and LC-MS data for MESA cohorts, enabling improved classification and enhanced biomarker interpretation (Multi-ethnic Study of Atherosclerosis, NIH study of 4000 patient cohort, US-based collaboration with clinical researchers and clinicians)

London, United Kingdom

Field engineer for high-res QToF-MS and UPLC instruments: repair, performance maintenance, troubleshooting and installation. Field-based and customer-facing role, with responsibility for supporting customers with research and clinical LC-MS applicationsFully trained for servicing and operation of Waters mass spectrometers (Xevo/Synapt QToF) and Xevo QToF Acquity (including I-Class, M-Class/nano, CTC autosamplers) for applications installations, repair and performance maintenance

Doctor Of Philosophy (Phd), Analytical Chemistry And Molecular Biology

‘Metabolic Consequences of Obesity in the Zucker Rat: A Mass Spectrometric and Chemoinformatic Study’ Supervisors: Professor Jeremy.

Master'S Degree, Chemistry, 2:1

MChem Chemistry with Study in Europe. MChem project: Synthesis and X-ray crystallographic analysis of metal-organic frameworks Erasmus.