Keith Spencer Email & Phone Number

Lyons, Co, Us

East Rutherford, New Jersey, Us

Still looking for success through client programs that makes an impact on the pharmaceutical landscape. IND and beyond, we provide the best platform to launch the next success in the marketplace in years to come. The key to forward motion appears to be quality. Fast and furious will not solve many problems within this stage of research for any program. Quality information and execution at small batches leads to downstream success every time. Short timelines lead to cracks in the foundation for any program that likely set roadblocks on your path through development. l value quality over time to ensure that everyone involved (Client and Cambrex) delivers the rock-solid path toward IND acceptance. Early programs matter! We are here to deliver just that. This is not a marketing ploy for Cambrex...this is what I truly believe. Dedication to solving complex issues with chemistry is important. Anyone that things that Organic Synthesis is a matter of access to Sci-Finder for the Pharmaceutical Industry is an absolute fool, period.

East Rutherford, New Jersey, Us

Multiple programs with great success. Life in a CDMO can be challenging, but very rewarding. Where there is a will, there is a way to develop the most formidable targets into commercial success. The Longmont PRD group, and supporting departments, is committed to seeing client programs progress to the next stage of development in a timely fashion. Our goal is to lead programs to IND success with hopes for commercial success.

East Rutherford, New Jersey, Us

Playing a role in taking promising lead small molecule candidates into drug development.

Antibiotic research that targets immediate needs. Tough-to-treat bacterial infections are likely to become a problem of the past with the exciting research at Crestone!

- Designed scalable protocols that removed specific impurities from crude fermentation-grade 3-hydroxypropanoic acid (3HP) that dramatically improves further purification processing. - Provided multi-kilogram quantities of synthetic 3HP from beta-propiolactone that served as a screening tool for Strain Development and Fermentation efforts. - Provided several metabolism standards to AR&D that serve as activity markers for various enzymes in the pathway to 3HP and other bio-based products. - Evaluated product stability and impurity profiles that determined MoC studies. - Lead the effort to commercialize 3HP by preparing a 17-kg batch of bio-derived sodium salt at >99.5% purity with over ten potential customer samples delivered. - Championed the effort to commercialize various 3HP derivatives for alternate uses beyond acrylic acid that offer higher value. - Assisted in the build-out of the Process laboratory to meet the equipment needs of the team with realistic budget considerations. - Developed and wrote SOPs for equipment use and commonly used procedures. - Actively participates in the Safety Committee to find ways to prevent time loss/injury and helped acquire ACC Responsible Care certification (2012-2015). - Implemented a pay-for-service agreement for local (Boulder) NMR analysis to complete our analytical needs. - Assisted in the joint research efforts toward commercializing “bio-acrylic acid” with our former partner, Dow Chemical Company. - Worked with the Fermentation Group to determine co-solvent conditions that allow consistent sampling of fatty acid methyl esters (FAME) in aqueous media. Continue to learn how to blend Process Research, Project Management and Business Development at OPX to help create a more efficient and marketable company platform.

Boulder, Co, Us

Staff Scientist: - Helped design, refine, and implement a second generation GMP process chemistry route that has been outsourced on 50 and 250 kg scale (Ipatasertib). - Exploited reaction parameters and physiochemical properties on a five-step GMP process route that gave high quality API employing simple isolations with a 33% higher overall yield. - Contributing inventor of the first successful process used by Genentech to provide API for clinical studies in oncology. - Worked with the MEK Process Team to improve the initial steps and refine the process chemistry route used today to provide Binimetinib. - Enabled several scalable synthetic strategies toward several clinical candidates, including the CHK inhibitor and TYK2 inhibitor projects. - Delivered several (gram to kilogram) batches of common intermediates to facilitate Medicinal Chemistry discovery efforts. - Implemented DOE strategies to solve optimization issues, when suitable. - Highly motivated to learn new technologies that aid the transfer of chemistry from the laboratory setting into a plant setting.Associate Scientist: - Independently researched and implemented synthetic routes to biologically active compounds with desirable drug characteristics. - AKT Inhibitor: Routinely evaluated SAR, ADME & modeling trends to target compounds that met efficacy requirements in vitro and in vivo. - Aided process colleagues in the redesign of the synthetic route toward the lead AKT inhibitor candidate from multi-gram to kilogram scale. - Worked closely with partnered colleagues to ensure technical transfer success.

Rahway, New Jersey, Us

- KDR Inhibitor: Developed novel chemistry to target selective KDR inhibitors while establishing medicinal chemistry skills. - CHK 1 Inhibitor: Aided in early pharmacophore development from a library screening hit using SAR from a primary protein binding assay. - Selective Androgen Receptor Modulators (SARMs): Advanced a novel and selective non-steroidal compound series into efficacy studies utilizing SARs, ADME data and physiochemical properties for a cell nucleus target. - Served on the West Point laboratory Safety Committee for two years and implemented changes to improve employee laboratory conditions.

Ms, Chemistry

Bs, Ba, Biology, Chemistry