Kendall Walker Phd.

Kendall Walker Phd. Email and Phone Number

Business Development | Pre-clinical Project Lead | Strategy | In Vivo Operations | Program Management @ Transpharmation Ltd.
Kendall Walker Phd.'s Location
San Diego County, California, United States, United States
Kendall Walker Phd.'s Contact Details
About Kendall Walker Phd.

As a research operations and business development professional, I specialize in contract R&D for the biotech and pharma industry. I partner with companies to accelerate their drug development programs by delivering tailored contract research solutions that meet their specific needs.With a decade of experience in the contract research industry, I have partnered with hundreds of biotech and pharma clients on diverse pre-clinical pharmacology projects. My expertise spans the entire drug development phase through to IND submission, across multiple therapeutic indications and modalities.Having successfully performed diverse roles at CRO's including scientific, operations and business development I possess a unique perspective when it comes to contract research that allows me to clearly understand a clients research needs, alignment with our service capabilities and execute high quality research projects.

Kendall Walker Phd.'s Current Company Details
Transpharmation Ltd.

Transpharmation Ltd.

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Business Development | Pre-clinical Project Lead | Strategy | In Vivo Operations | Program Management
Kendall Walker Phd. Work Experience Details
  • Transpharmation Ltd.
    Bd Director - West Coast Usa
    Transpharmation Ltd. Sep 2024 - Present
    London, England, Gb
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  • Porsolt
    Director Of Business Development - North America
    Porsolt Nov 2022 - Sep 2024
    Le Genest-Saint-Isle, Fr
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  • Porsolt
    Associate Director Of Business Development - West Coast North America
    Porsolt Apr 2018 - Nov 2022
    Le Genest-Saint-Isle, Fr
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  • Psychogenics
    Senior Scientist
    Psychogenics Jan 2017 - Apr 2018
    Paramus, New Jersey, Us
    Responsible for managing multiple concurrent pre-clinical research projects for biotech, pharma, & non-profit organizations focused on Huntington’s Disease, Parkinson’s Disease, Muscular Dystrophy & Spinal Muscular Atrophy.Direct all aspects of client projects from advising on experimental design, preparing study proposals & pricing, resource allocation, analysis of study data & preparation of reports & client presentations. Lead a team of 5-8 research associates (RA’s) to facilitate the successful completion of client studies. Responsible for hiring & training of new RA’s for the Neurodegenerative Disease (NDG) group at PsychoGenics Inc. Co-manage studies involving molecular, biochemical, behavioral & electrophysiological phenotyping of novel & commercial murine NDG models to investigate underlying disease biology & identify therapeutically relevant biomarkers.Execute pre-clinical ligand validation studies (MTDs, PK/PD) & also pre-clinical ligand efficacy studies in murine NDG models via traditional dosing routes or stereotaxic administration to the CNS.Direct behavioral phenotyping of NDG mouse models utilizing standard behavioral assays as well as PGI proprietary cubes technologies to identify critical behavioral features contributing to disease biology & are suitable for assessment of investigational compounds.Perform stereotaxic surgical R&D projects in a technical specialist capacity, with an emphasis on developing & refining surgical techniques for clients requested method development as well as internal R&D efforts. This includes producing hand-made infusion apparatuses to ensure test article compatability & improve compound diffusion parameters. Validated & trained RA’s in Parkinson’s disease surgical models including chemical lesioning (4-point 6’OHDA) & alpha-synuclein seeding/prion spreading models. Responsible for all client as well as internal R&D efforts based around alpha-synuclein seeding/prion spreading surgical models.
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  • Psychogenics
    Scientist
    Psychogenics Jan 2016 - Dec 2016
    Paramus, New Jersey, Us
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  • Psychogenics
    Associate Scientist
    Psychogenics Jan 2015 - Dec 2015
    Paramus, New Jersey, Us
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  • Tufts University School Of Medicine
    Post Doctoral Fellow - Neuroscience Department
    Tufts University School Of Medicine May 2009 - Dec 2014
    Boston, Ma, Us
    Laboratory specializes in the identification of BACE1 regulatory mechanisms for the treatment of Alzheimer’s Disease (AD). Advisor: A/Prof. Giuseppina Tesco I am currently investigating the pathological role of BACE1 elevation as well as the therapeutic potential of BACE1 regulation following experimental TBI. Additionally, I am also spearheading an innovative project that is focused on dissecting the role of a novel molecular target implicated in the anxiety and depression circuitry in the rodent brain.Key Research Highlights:• Demonstrated a crucial role for the BACE1 regulating molecule (GGA3) in the aging brain • Identified & published the first known molecular mechanism (caspase mediated depletion of GGA3 & GGA1) responsible for regulating BACE1 activity & Aβ production following TBI. • Demonstrated that GGA3 haploinsufficiency (as occurs in the brains of AD patients) is an important risk factor for the development of chronic neurodegeneration following TBI. • Developed an improved fluorimetric method for measuring BACE1 activity in mouse brain tissue, a notoriously difficult assay to perform accurately. Published J. Neurosci. 2012.• Identified a novel behavioral phenotype associated with GGA3 induced elevation of BACE1 in the GGA3KO mouse model (manuscript in preparation)• Collaborated on an additional four research projects with A/Prof. Chris Dulla, TUSM; Prof. Philip G.Haydon, TUSM; Prof. Steven J Moss, TUSM and Dr. Luca Longhi, Uni. of Milan• Manuscript review: Nat. Sci. Rep., Open Neurol. J. and J. Neurosci.• Wrote &/or assisted in the writing of grants for AHAF, CAF, DOD &NIH• Responsible for the direct management of a research technician and daily supervision and training of all laboratory staff. Teaching of graduate student laboratory boot camp courses. Designed & implemented all Animal Ethics, Biohazard & EHS protocols for the labTechniques used are listed under individual projects
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  • Massachusetts General Hospital; Harvard Medical School
    Post-Doctoral Fellow Neurology Department
    Massachusetts General Hospital; Harvard Medical School Apr 2008 - Apr 2009
    Boston, Ma, Us
    Molecular Neurodegeneration Laboratory, Genetics and Aging Unit.Lab specializes in the identification of BACE1 regulatory mechanisms for therapeutic treatment of Alzheimer’s DiseaseAdvisor: A/Prof. Giuseppina TescoResearch focuses on the role of GGA3 mediated BACE1 stabilization in Alzheimer’s Disease (RO1AG025952-01A1)• Research demonstrated an important molecular mechanism for BACE1 elevation and neurotoxic Aβ production (caspase-mediated depletion of the intracellular trafficking protein GGA3) and provides a novel therapeutic target for AD treatment. - Demonstrated that the normal cellular function of GGA3 is to bind BACE1 and traffic it to the lysosomes for degradation. - This research explains a crucial mechanism by which caspase-mediated depletion of GGA3 results in increased BACE1 activity and Aβ production in vitro and provides an alternative to small molecule BACE1 inhibitors for the treatment of AD. [Published J. Biol. Chem. 2010]• Collaborated with Drs. Michael Whalen and Rebekah Mannix of the Centre for Neuroscience at MGH to examine the effect of APOε4 on outcome following TBI. Performed Aβ ELISA’s that demonstrated that the APOε4 gene regulated soluble Aβ production following traumatic brain injury only in mature mice not immature mice demonstrating an important age-dependent effect of APOε4 on functional outcome. [Published J. Cereb. Blood Flow and Metab. 2010]Techniques used include: neuronal culturing from rodents, rodent surgery (stereotaxic and lesioning), immunohistochemistry, quantitative confocal analysis, ELISA and western blotting.
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  • Massachusetts General Hospital; Harvard Medical School
    Post-Doctoral Fellow Neurology Department
    Massachusetts General Hospital; Harvard Medical School Oct 2006 - Apr 2008
    Boston, Ma, Us
    Cecil B Day Neuromuscular Lab, Massachusetts General Hospital.Lab focuses on the genetics of neuromuscular and neurological disorders, in particular ALS. Advisor: Prof. Robert H Brown JrAngel Fund Fellow 2007 - awarded financial support by the independent ALS charity.Research focuses on RVG peptide delivery of IGF-1, VEGF and mutant SOD1 siRNA’s to the CNS for the treatment of ALS• Performed in vitro studies to silence mutant G93A SOD1 using siRNAs electrostatically coupled to a novel cell penetrating peptide based upon the rabies virus glycoprotein (RVG).• Designed and expressed recombinant neurotrophic factors IGF-1 and VEGF with the RVG sequence as a protein transduction domain using the Baculovirus expression system (BEVS).• Supervised a graduate student from Harvard College for the practical component of her degree.Techniques used include: plasmid design and construction, recombinant protein production using BEVS, gene silencing using siRNA’s, confocal analysis, western blotting and dosing via i.p. and tail vein in G3ASOD1 mice.
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  • Waimr - University Of Western Australia
    Graduate Research Assistant
    Waimr - University Of Western Australia Aug 2003 - Oct 2006
    Perth, Western Australia, Au
    Molecular Neurogenetics Laboratory, Western Australian Institute for Medical Research (WAIMR) specializes in the genetics and biochemistry of rare neuromuscular diseases.Lab Head: Prof. Nigel G Laing• Identified disease-causing mutations for nemaline myopathy and congenital fibre type disproportion. [Published Ann. Neurol. 2004; Ann. Neurol. 2007]• Collaborated with the Western Australian Health Department to optimize their southern blot assay for myotonic dystrophy (DM1) in clinical samples.• Produced and purified recombinant thin filament proteins (skeletal α-actin, α-tropomyosin-1 and α-tropomyosin-3) using the BEVS for functional studies of congenital myopathy pathogenesis. [Published Biochem. Biophys. Res. Comm 2003; J. Neuropathol. Exp. Neurology 2008]• Initiated and completed a candidate gene-screening project of an Australasian cohort of non-SOD1 familial and sporadic ALS patients. This study was awarded a 25K grant-in-aid from the Motor Neuron Disease Research Institute (MNDRI) of Australia.•Responsible for training research assistants and graduate students. Co-edited manuscripts for Sciencedit, a company specializing in editing and writing assistance for researchers with english as a second language.Techniques used include: recombinant protein production and purification (BEVS), DNA/RNA extraction (blood and tissue), std and mutagenic PCR, sequencing, SSCP, southern blotting.
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  • Murdoch University
    Phd Candidate Researcher
    Murdoch University 2000 - 2006
    Perth, Western Australia, Au
    This research Institute focuses on uncovering the genetic and environmental causes of disease. Advisors: Prof. Nigel G Laing & Prof. John Howell•Characterized the molecular and biochemical phenotype of the ovine model of McArdle’s disease, a metabolic disease affecting skeletal muscle. Analyzed the ability of butyric acid to re-express the fetal isoform of glycogen phosphorylase in muscle as a potential therapeutic strategy for McArdle’s disease.•Demonstrated that exploitation of gene redundancy through the re-expression of the fetal isoform of glycogen phosphorylase via myotoxin induced muscle regeneration is a potential therapeutic strategy.•Demonstrated that injection of AAV’s expressing muscle glycogen phosphorylase into the muscle of McArdles’ affected sheep was able to restore glycogen degradation and the expression of functional glycogen phosphorylase and is valid therapeutic strategy. [Published Neuromusc. Disord. 2008]•Trained research assistant/junior graduates. Designed/implemented vivisection (animal ethics) registrations.Techniques used include: recombinant protein production (BEVS), Purification of recomb. and non recomb. proteins (Affinity, ion exchange, size exclusion), polyclonal antibody production and purification (rodents), northern blotting, nuclease protection assays, western blotting, and microarray.
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  • Self Employed
    Contractor - Pre-Clinical Researcher
    Self Employed 2002 - 2003
    Sub-contractor of custom research services for Molecular Research Technologies (Pty Ltd).

Kendall Walker Phd. Skills

Neuroscience Immunohistochemistry Molecular Biology Western Blotting Alzheimer's Disease Confocal Microscopy Protein Chemistry Elisa Cell Culture Animal Models Cell In Vivo Cell Biology In Vitro Genetics Molecular Cloning Neurodegenerative Disease Molecular Neuroscience Neurobiology Cns Disorders Traumatic Brain Injury Behavioral Neuroscience Primary Neuronal Culturing Assay Development Rodent Behavioral Analysis Molecular Biology Protein Based Techniques Lentivirus Baculovirus Immunocytochemistry Northern Blotting Rare Diseases Amyotrophic Lateral Sclerosis Neurodegeneration Grant Writing Statistical Data Analysis Stereotaxic Surgery Rodents

Kendall Walker Phd. Education Details

  • Murdoch University
    Murdoch University
    Biotechnology
  • Murdoch University
    Murdoch University
    Veterinary Biology And Biomedical Science

Frequently Asked Questions about Kendall Walker Phd.

What company does Kendall Walker Phd. work for?

Kendall Walker Phd. works for Transpharmation Ltd.

What is Kendall Walker Phd.'s role at the current company?

Kendall Walker Phd.'s current role is Business Development | Pre-clinical Project Lead | Strategy | In Vivo Operations | Program Management.

What is Kendall Walker Phd.'s email address?

Kendall Walker Phd.'s email address is ke****@****fts.edu

What is Kendall Walker Phd.'s direct phone number?

Kendall Walker Phd.'s direct phone number is +161763*****

What schools did Kendall Walker Phd. attend?

Kendall Walker Phd. attended Murdoch University, Murdoch University.

What are some of Kendall Walker Phd.'s interests?

Kendall Walker Phd. has interest in Economic Empowerment, Education, Science And Technology, Human Rights, Animal Welfare, Health.

What skills is Kendall Walker Phd. known for?

Kendall Walker Phd. has skills like Neuroscience, Immunohistochemistry, Molecular Biology, Western Blotting, Alzheimer's Disease, Confocal Microscopy, Protein Chemistry, Elisa, Cell Culture, Animal Models, Cell, In Vivo.

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