Ken Mariash Email and Phone Number
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As CEO of Sinaptica, Ken is leading the team to advance their personalized closed-loop neuromodulation therapy for Alzheimer's, which has generated unprecedented Phase 2 sham-controlled clinical data that was recently published in the Oxford journal, 'Brain.' Sinaptica has FDA Breakthrough status for its novel proprietary approach which combines rTMS, EEG, and Neuronavigation with a sophisticated ML-derived personalization engine based on a novel brain target-- the precuneus, the central hub of the Default Mode Network, a brain network involved in episodic memory. The company has completed all clinicals to date with non-dilutive funding, and is now in-process on a financing to complete the clinical product (SinaptiStim™️ - AD) and prepare to initiate a pivotal study in 2025.Previously to Sinaptica, Ken has 20+ years leading and growing new business ventures on both the 'Buy Side' and the 'Build Side.' He started his career in management consulting at Charles River Associates, then jumped to industry at CSL, then Baxter BioScience (now Takeda), and Boston Scientific, with leadership roles in marketing, strategy, and corporate development. At Boston Scientific's nearly $1B Neuromodulation division, he was the global commercial lead for the highly successful Cosman RF ablation business he helped acquire. He also built the division’s Strategy function, providing leadership in areas including strategic planning, BD assessment, R&D portfolio management, digital strategy, and investments in next-gen platforms & new indications. In 2019 he joined EBT Medical, a venture-backed, clinical-stage startup developing a disruptive neuromodulation device for overactive bladder, where he oversaw all commercial aspects.
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CeoSinaptica Therapeutics Feb 2023 - PresentCambridge, Ma, UsInvented by Profs Giacomo Koch MD, PhD and Emiliano Santarnecchi, PhD, PsyD, Sinaptica is developing closed-loop neuromodulation therapy for Alzheimer's with published Phase 2 sham-controlled efficacy which is highly statistically significant on four gold-standard cognitive and functional endpoints, and is more pronounced than any drug to date, earning FDA Breakthrough Designation. Sinaptica's novel proprietary approach combines rTMS, EEG, and Neuronavigation with a sophisticated ML-derived personalization engine, targeting the Precuneus, the central hub of the Default Mode Network, involved in episodic memory. The company now has data from a second phase 2 which confirms all 6-month trends are durable to 1 year. Their bold new approach represents a major potential breakthrough in how we think about, diagnose, and treat Alzheimer's. -
Founder & Managing PartnerRubicon Strategy Partners, Llc Jun 2022 - PresentA "decision" can be defined as an irrevocable commitment of resources. We help leadership make the big investment decisions: around fundraising, portfolio, market entry, M&A, and launch strategy. We support decision-making with quantitative pricing studies, market validation research, CAC assessment, decision analysis, and go-to-market strategy (including digital)-- supported by sophisticated financial modeling. Therapeutic areas include neuromodulation, pain, CNS/neurology, urology, biosurgery, pulmonology, chronic wounds, Parkinson's, regenerative medicine, ortho/spine, digital therapeutics, vaccines, and many more. -
Vice President Of MarketingEbt Medical, Inc. Sep 2019 - May 2022Toronto, Ontario, CaFull-time employee #2 overseeing all commercial aspects • Product - Owned user requirements for novel neurostimulator + companion app, from napkin sketch to V&V in 2.5 yrs. Oversaw ethnographic and human factors-driven design &development incl UI/UX.• GTM - Developed go-to-market strategy including salesforce planning, positioning/messaging, telemedicine, pricing, reimbursement, direct-to-patient promo, and organizational expansion plan. • Market Research - Drove six market validation studies including online CAC and pricing exercises. • Physician Marketing - Authored physician influence plan and successfully engaged 40+ KOLs. • R&D Roadmap - Commercial input to clinical strategy and long-term product / indication roadmaps. • Fundraising - Coauthored Series A and Series B business plans. Pitched VCs, strategics, angel groups, startup competitions, and high net worth individuals.• Branding - Oversaw creation of all collateral, visuals, animations, and messaging, including UI/UX.• Financials - Created fully-parameterized financial model and detailed market segmentation. • Hiring - Pivotal role sourcing key leadership talent, consultants, and C-level advisors. -
Director, Strategy And New MarketsBoston Scientific Neuromodulation Aug 2011 - Sep 2019Marlborough, Ma, Us• WW Franchise Lead - Drove 2016 acquisition of the Cosman RF ablation business, providing leadership impacting nearly every aspect of integration and ongoing operations, including product roadmap, sales force model and incentives, downstream marketing, bundling, mfg transfer, training, KOLs, clinical, etc. ‣ Results: Cosman growth strongly outperformed deal model, trending a full year ahead of plan and continues to outperform 5 years later.• Head of Strategy - Founded and led divisional Strategy function for 8 years as sales nearly tripled from ~$300M to ~$900M, with responsibility for strategic planning, market research, CI, business analytics, R&D portfolio prioritization, and BD assessments. • Digital Strategy - Co-authored division's digital strategy including connectivity, companion apps, and remote patient mgmt, which won an $8-digit incremental funding commitment.• Implantable Development & Launch - Participated in the needs-assessment, design, development, launch, and scaling of several implantable stimulators including Precision Spectra™️ (Prix Galien nominee) and WaveWriter™️ . Oversaw development of a novel implantable neurostimulator with external partner, which became Sacramed.• Companion Apps - Drove JV with BCG Digital Ventures which resulted in PainScale, the first digital 'product' for BSN. -
Group Manager, Strategy & Business DevelopmentBaxter Bioscience Jul 2004 - Aug 2011Deerfield, Illinois, Us• Led strategic market assessments • Evaluated and championed acquisitions • Drove business planning for multiple franchises• Facilitated corporate strategy development• Supported Sr leadership in crafting & articulating long-term vision • Key driver of R&D portfolio management process • Led ad hoc decision analysis projects -
Product ManagerCsl Behring Jan 2003 - Jun 2004Melbourne, Victoria, Au• Key contributor to US launch of Carimune, a $300M biologic immunotherapy • Created marketing plans, branding guidelines• Supported advisory boards on positioning/messaging, and on clinical trial design• Executed pre-launch activities for Carimune's successor formulation• Pointperson for KPIs, pricing, and supply chain analytics -
Project ManagerCharles River Associates Nov 1998 - Apr 2002Boston, Ma, Us• Contributed to strategic recommendations for blockbuster Big Pharma launches• Conceived and drove development of DirectEvent®, a proprietary financial analysis software tool • Contributor on numerous asset valuation engagements • Healtheconomic research on the value of various drugs and medical devices -
Research Associate, FinanceHarvard Business School Jun 1997 - Aug 1998Boston, Ma, UsSupported three professors of finance in their original research on investment decisions and risk arbitrage.
Ken Mariash Skills
Ken Mariash Education Details
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Brown UniversityBusiness/Managerial Economics
Frequently Asked Questions about Ken Mariash
What company does Ken Mariash work for?
Ken Mariash works for Sinaptica Therapeutics
What is Ken Mariash's role at the current company?
Ken Mariash's current role is Developing personalized precision neuromodulation for Alzheimer's.
What is Ken Mariash's email address?
Ken Mariash's email address is km****@****hoo.com
What is Ken Mariash's direct phone number?
Ken Mariash's direct phone number is +166190*****
What schools did Ken Mariash attend?
Ken Mariash attended Brown University.
What are some of Ken Mariash's interests?
Ken Mariash has interest in Social Services, Health.
What skills is Ken Mariash known for?
Ken Mariash has skills like Strategy, Product Launch, Medical Devices, Start Ups, Pharmaceutical Industry, Product Development, Biotechnology, Business Strategy, Marketing Strategy, Market Research, Cross Functional Team Leadership, Management.
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