Member of the graduate faculty for the program in bioinformatics and computational biology (BICB)

Current: Not taking new contract work. Always happy to make referrals to exceptionally skilled independent consultants in bioinformatics, data science, translational medicine, and commercial healthcare.Past: client list includes IBM, Pfizer, Dexcom, and Flagship Pioneering.

Real-world evidence generation for protein-based diagnostic tests in cardiometabolic health.

Worked across business segments to deploy evidence-based solutions for highly impactful medical conditions, including infectious disease, autoimmune, rare genetic disease, cardiovascular disease, and cancer• Led teams involved in observational studies, health economics and outcomes research, protocol design and implementation of large-scale pilots• Technical diligence for corporate development (ventures, mergers & acquisitions)• Board Observer at Scipher Medicine

Promoted to guide business and product development in the areas of cancer immunotherapy and genomic medicine

Managed people and programs supporting laboratory testing, donor-patient matching (histocompatibility), and web-based clinical decision support

Promoted to manage a newly constituted department with corporate imperatives to advance product quality, increase data-driven decision support, and improve operational efficiency• Enhanced methods to access more human genetic variation with short sequencing reads• Led a company-wide effort to move high-performance compute off-premises (to the cloud)• Directed use of advanced analytics, unsupervised machine learning, and NoSQL databases for ad hoc research and business intelligence purposes• Consulted with executive leadership as well as clinical and scientific advisory boards on strategic corporate objectives, R&D opportunities, potential new markets and revenue sources

Recruited as the tenth employee to build critical technology for the first clinical-commercial application of high-throughput (next-generation) DNA sequencing for routine, guideline-recommended genetic testing• Completed comprehensive analytical and clinical validation of in vitro diagnostic assays• Developed platform software for integrating high-velocity genomic data with enterprise resource planning and relational database management systems• Produced CLIA- and CAP-compliance documentation supporting product launch (April, 2012)

Built customer-facing, open source software for the SOLiD DNA sequencing platform• Developed algorithms for detecting structural variation in multiple organisms• Used test-driven development methods to improve algorithmic performance and keep apace of rapidly advancing technology while maintaining high quality and accuracy standards• Reported dashboard-level progress to senior management• Analyzed whole-genome sequencing data to detect germline and somatic genetic variation• Provided contract research services; produced technical documentation and user manuals

Conducted independent thesis research in systems and synthetic biology• Developed a computational (constraint-based) model of yeast metabolism, using experimental techniques to validate model predictions• Designed and implemented a novel Bayesian method to characterize functional localization of chromatin at mammalian nuclear pore complexes using tiled microarrays• Collaborated with the RNAi Global Initiative (coordinated by Thermo Fisher Scientific) and the core screening facility at Harvard Medical School to implement accurate hit-identification in cell-based siRNA screens using supervised machine learning (support vector machines) to discover modulators of apoptosis, nuclear transport, and respiratory metabolism • Utilized high-throughput cloning to generate a library of artificial, human zinc finger transcription factors for use in cell-based screens

Characterized cellular events involved in early central nervous system development in fly• Implemented genetic screens and performed experiments using various techniques: PCR, molecular cloning, in situ hybridization, immunohistochemistry, and fluorescence microscopy• Maintained fly stocks, prepared specimens for histological examination (microtome cryostat)

Completed graduate coursework and thesis research at the Visualization Laboratory, an innovative program combining art, science, and technology for digital communication• Built and analyzed spatial-temporal reconstructions of confocal micrographs from transgenic tobacco cells using the Visualization Toolkit (VTK), OpenGL, and Maya• Scientific illustration (technical pen on Bristol board) of tropical Myristicaceae (nutmeg)