Keri Dame Email & Phone Number

Manchester, New Hampshire, United States

Silver Spring, Maryland, United States

Center for Drug Evaluation and Research (CDER), Office of Translational Sciences (OTS), Office of Clinical Pharmacology (OCP), Division of Applied Regulatory Sciences (DARS)

Silver Spring, Maryland

• Center for Drug Evaluation and Research (CDER), Office of Translational Sciences (OTS), Division of Applied Regulatory Sciences (DARS)
• Experimentally defined context of use for emerging platforms integrating hiPSC-derived lineages (heart, liver) in engineered cellular systems with primary applications for evaluating drug safety by experimentally.
• Contributed to multiple interdisciplinary collaborations including projects using artificial intelligence to detect and quantify drug toxicity (company collaboration) and for evaluating drug testing applications with a.
• Pioneered in-house hiPSC differentiation methods to cardiomyocytes and hepatocytes as platforms for modeling and predicting drug adverse effects. Established single-cell RNA analysis methods to interrogate cellular.
• Reported findings to management, at division meetings and conferences, and through scientific publications.

Boston, MA, USA

• Doctoral Research | Mentor: Laertis Ikonomou, PhD
• Investigated mechanisms of thyroid specification during mESC differentiation using transient overexpression of a transcription factor (Nkx2-1) to greatly enhance derivation of thyrocytes.
• Studied endodermal derivation and patterning leading to thyroid competence and characterized derived progeny using a variety of protein, transcriptional, and functional analysis techniques.
• Developed a mouse model to recapitulate the in vitro findings on Nkx2-1-driven thyroid specification.

Cambridge, MA, USA

• Employed through the rigorous launch phase of a biotech startup specializing in genetic carrier screening.
• Conducted diagnostic assays (Cystic Fibrosis, Fragile X, SMA, alpha thalassemia) with high volume patient sample tracking and automated liquid handling.
• Finalized protocols, performed assay troubleshooting, analyzed and submitted patient results, and user-tested analysis and result submission programs.

Boston, MA, USA

• Senior Technician (Jan 2011 - Aug 2012)Technician (March 2009 - Jan 2011)
• Provided and coordinated services to research labs on aging, Alzheimer’s, breast/colon cancer, diabetes & others.
• Extracted DNA from various tissues, performed DNA analysis techniques (Sanger sequencing, PCR amplification, SNP genotyping) at low to high volume, established and stored lymphoblast cell lines.
• Enhanced data organization and precision of record-keeping. Also maintained equipment, inventory, and order requests. Developed SOPs, trained technicians, and delegated tasks to optimize productivity & project.

Doctor Of Philosophy (Ph.D.), Genetics & Genomics

•Graduate Program in Genetics and Genomics, Biomedical Sciences •Doctoral Thesis: Derivation of thyroid progenitors from embryonic stem.

Bachelor Of Science (B.S.), Biology, General, 3.662