Supported client's analytical R&D department. Performed analytical testing using various instrumentation, including: GC (direct inject and HS-GC; Agilent), HPLC and UHPLC (Agilent and Waters), LC-MS (Waters), SFC (Waters), UV-Vis (Agilent), qNMR (Bruker), XRF (Thermo Scientific), Karl Fischer (Metrohm), chloride autotitrations (Metrohm); performed assay and purity analyses, determined concentrations of residual solvents, executed Stage 1 & Stage 2 method validations; determined molar extinction coefficients (MEC) for phototoxicity assessments; completed training for dry dispersion particle size analysis; processed data using Chemstation and Empower; maintained an electronic laboratory notebook for documentation of experiments (Biovia eLN)

Supervised a QC laboratory at a mid-sized cGMP CMO. Served as a resource for technical questions, represented QC in cross-departmental meetings, interfaced with clients regarding agreeable timelines and requests for deliverables, organized analyst workloads for efficient delivery of results. Trained analysts on various laboratory techniques. Reviewed experimental documentation for raw materials, IPCs, finished products and stability samples in laboratory notebooks and excel, or in LIMS. Reviewed and authored validation protocols and reports. Oversaw QC generation of investigation reports and CAPAs. Provided high-level analytical testing support, method development, method optimization and validation.

Performed similar tasks listed in Associate Scientist I level, with increased focus on method development and optimization, method validation, process validations, and providing analysts with training. Major contributor to the validation of LIMS for use in the laboratory, during its implementation process (prior, physical laboratory notebooks and excel were employed).

Performed quality control testing of finished product, packaging, raw material and stability samples; supported manufacturing by performing in-process assays, pH checks and pH adjustments; performed method validations and process validations; updated and created controlled documents; utilized analytical techniques and instrumentation including HPLC, pH, viscosity (LV and RV viscometers), UV-Vis Spectrophotometry (Shimadzu), Karl Fischer, wet chemistry, FTIR, and GC; performed calibration checks of instrumentation; cGMP and GLP compliance; worked with Agilent HPLCs and gained a working knowledge of ChemStation Software; familiarized with Agilent and Shimadzu GCs

•Managed the Ram’s Den, a multi-million dollar dining operation; trained and supervised employees on all stations and ensured customer satisfaction

Project: Chemical Biology of Nucleic Acid Modification: The Intersection of DNA Repair, Metabolism, and Antiviral Drug Design• Reverse phase HPLC oligonucleotide purification (utilized Chromeleon HPLC software); NanoDrop to determine DNA concentrations; MERMADE for DNA oligonucleotide synthesis; lyophilization; preparation of buffer solution and mobile phase, 2XYT media, LB agarose media and plates; development and maintenance of oligonucleotide inventory within the lab; preparation of high resolution MS inserts; autoclaving; presented a poster at 2016 RI Section ACS Poster Session on “Spectroscopic Methods for Identifying Products and Byproducts in Oligonucleotides Synthesis”; trained and mentored incoming laboratory membersAcknowledged in the following articles:Nucleic Acids Res. 2019 Jun 20; 47(11): 5522–5529. Published online 2019 May 22. doi: 10.1093/nar/gkz395Chem. Res. Toxicol. 2017, 30, 10, 1794–1796. Publication Date:September 19, 2017. https://doi.org/10.1021/acs.chemrestox.7b00230ACS Omega 2017, 2, 11, 8205–8212. Publication Date:November 20, 2017. https://doi.org/10.1021/acsomega.7b01482

▪ Developed tables for patients needing to monitor K counts, guanine, and/or caffeine contents in vitamins and beverages; Complied with HIPAA regulations; Attended presentations regarding ethical care to patients; Monitored (with a pharmacist) patient’s medical records and medication currently being administered; Edited a fellow intern’s research paper