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Formulation/CMC Scientist with 8 years of industry experience. Excellence in preclinical formulation development, amorphous solid dispersions, API form discovery/developability assessment, solid-state characterization, and crystallization.
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Principal Scientist, Preclinical Formulation DevelopmentVertex PharmaceuticalsBoston, Ma, Us -
Principal Scientist, Formulation DevelopmentVertex Pharmaceuticals Aug 2023 - PresentBoston, Ma, Us
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Senior Scientist, Formulation DevelopmentVertex Pharmaceuticals Sep 2020 - Aug 2023Boston, Ma, Us• Selected as CMC team representative for several assets in various stages of clinical development• Appointed lead formulator for multiple research projects in lead optimization, responsible for developing all preclinical formulations• Discovered crystalline forms of lead API candidates, and contributed extensively to form selection and developability assessment• Discovered fit-for-purpose crystallization processes utilized to manufacture API batches for FIH clinical trials• Developed API formulations for dosimetry/ADME studies• Authored formulation preparation instruction documents to transfer processes to CROs
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Scientist, Formulation DevelopmentVertex Pharmaceuticals Feb 2020 - Sep 2020Boston, Ma, Us• Assessed physicochemical properties of early development compounds including chemical and physical stability, solubility in formulation vehicles and biorelevant media, and evaluated pH-dependent solubility/stability• Developed stable formulations of APIs to support in vivo PK, pharmacology, and GLP toxicology studies• Assessed physical properties of early API lots, and evaluated numerous solid forms utilizing solid state characterization techniques• Preformed crystal form screening of APIs to generate polymorphs and salt forms
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Scientist, Pharmaceutical Chemistry And Formulation DevelopmentAlkermes Sep 2017 - Nov 2019Dublin, Ie• Characterized novel APIs and prodrugs comprehensively in both the solid state to identify physical form/assess crystallinity, and liquid state (HPLC, qNMR) to determine purity• Developed experiments to determine and manipulate physical form, to evaluate solubility in various organic solvents, and to grow single crystals of lead compounds• Milled discovery compounds for particle size control• Synthesized and evaluated analogues, metabolites, and prodrugs of compounds of interest for CNS programs to enhance drug properties and improve bioavailability• Collaborated extensively with medicinal chemistry and DMPK/BA groups• Mentored and trained multiple early career scientists in laboratory techniques -
Vertex Fellow, Medicinal ChemistryVertex Pharmaceuticals Sep 2016 - Sep 2017Boston, Ma, UsThe Vertex Fellows Program is a unique, one-year opportunity for scientists to be embedded in active project teams, with direct mentorship from senior scientific leaders including our CSO and Vice Presidents. My training at Vertex was focused in medicinal chemistry and I was responsible for designing and synthesizing novel small molecules for a pulmonary drug discovery program in lead optimization.
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Postdoctoral Associate, Koch Institute And Department Of Chemical EngineeringMassachusetts Institute Of Technology Feb 2015 - Sep 2016Cambridge, Ma, UsResearch Project: Development of Glucose-Responsive Insulin Analogues for Self-Regulated Diabetes TherapyAdvisors: Professors Daniel G. Anderson and Bob Langer -
Ph.D., Organic ChemistryUc San Diego Sep 2009 - Jan 2015La Jolla, Ca, UsDissertation: Prodrug Strategies for Metalloenzyme Inhibitors and Molecular Imaging AgentsAdvisor: Professor Seth M. CohenDepartment of Chemistry and BiochemistryI was a graduate student in the organic chemistry division specializing in the design, synthesis and evaluation of novel prodrugs targeting metalloenzymes implicated in diseases such as cancer.
Kevin Daniel Skills
Kevin Daniel Education Details
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Uc San DiegoOrganic Chemistry -
University Of North Carolina At Chapel HillSpanish
Frequently Asked Questions about Kevin Daniel
What company does Kevin Daniel work for?
Kevin Daniel works for Vertex Pharmaceuticals
What is Kevin Daniel's role at the current company?
Kevin Daniel's current role is Principal Scientist, Preclinical Formulation Development.
What is Kevin Daniel's email address?
Kevin Daniel's email address is kb****@****unc.edu
What is Kevin Daniel's direct phone number?
Kevin Daniel's direct phone number is +191991*****
What schools did Kevin Daniel attend?
Kevin Daniel attended Uc San Diego, University Of North Carolina At Chapel Hill.
What skills is Kevin Daniel known for?
Kevin Daniel has skills like Organic Chemistry, Organic Synthesis, Medicinal Chemistry, Drug Discovery, Drug Design, Hplc, Nmr Spectroscopy, Flash Chromatography, Uv/vis, Lcms, Mass Spectrometry.
Who are Kevin Daniel's colleagues?
Kevin Daniel's colleagues are Rakhi Morjaria, Adrienne Amador Guerrero, Christine Bailey, Angelo Saravia, Erin Brozik, William Joyce, Liz Yurkewych.
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