Kevin Daniel Email & Phone Number

Boston, Ma, Us

Boston, Ma, Us

Boston, Ma, Us

• Selected as CMC team representative for several assets in various stages of clinical development• Appointed lead formulator for multiple research projects in lead optimization, responsible for developing all preclinical formulations• Discovered crystalline forms of lead API candidates, and contributed extensively to form selection and developability assessment• Discovered fit-for-purpose crystallization processes utilized to manufacture API batches for FIH clinical trials• Developed API formulations for dosimetry/ADME studies• Authored formulation preparation instruction documents to transfer processes to CROs

Boston, Ma, Us

• Assessed physicochemical properties of early development compounds including chemical and physical stability, solubility in formulation vehicles and biorelevant media, and evaluated pH-dependent solubility/stability• Developed stable formulations of APIs to support in vivo PK, pharmacology, and GLP toxicology studies• Assessed physical properties of early API lots, and evaluated numerous solid forms utilizing solid state characterization techniques• Preformed crystal form screening of APIs to generate polymorphs and salt forms

Dublin, Ie

• Characterized novel APIs and prodrugs comprehensively in both the solid state to identify physical form/assess crystallinity, and liquid state (HPLC, qNMR) to determine purity• Developed experiments to determine and manipulate physical form, to evaluate solubility in various organic solvents, and to grow single crystals of lead compounds• Milled discovery compounds for particle size control• Synthesized and evaluated analogues, metabolites, and prodrugs of compounds of interest for CNS programs to enhance drug properties and improve bioavailability• Collaborated extensively with medicinal chemistry and DMPK/BA groups• Mentored and trained multiple early career scientists in laboratory techniques

Boston, Ma, Us

The Vertex Fellows Program is a unique, one-year opportunity for scientists to be embedded in active project teams, with direct mentorship from senior scientific leaders including our CSO and Vice Presidents. My training at Vertex was focused in medicinal chemistry and I was responsible for designing and synthesizing novel small molecules for a pulmonary drug discovery program in lead optimization.

Cambridge, Ma, Us

Research Project: Development of Glucose-Responsive Insulin Analogues for Self-Regulated Diabetes TherapyAdvisors: Professors Daniel G. Anderson and Bob Langer

La Jolla, Ca, Us

Dissertation: Prodrug Strategies for Metalloenzyme Inhibitors and Molecular Imaging AgentsAdvisor: Professor Seth M. CohenDepartment of Chemistry and BiochemistryI was a graduate student in the organic chemistry division specializing in the design, synthesis and evaluation of novel prodrugs targeting metalloenzymes implicated in diseases such as cancer.

Doctor Of Philosophy (Ph.D.), Organic Chemistry

Bachelor Of Arts (B.A.) With Honors, Chemistry, Spanish