INEYE PHARMA: The real innovation is trust.INEYE PHARMA reinvents the trusted third party in preclinical development. Supported by the Bioincubator EURASANTÉ, INEYE PHARMA is the first global C.R.O. project dedicated to ocular diseases to implement the Blockchain technology in pre-clinical trials.

Department of neurology / neurosurgery

Pre-clinical project focused on preterm parenteral nutrition, and hepatic consequences of a modulation of oxidative stress._ Pilot study based on pediatric formulation of Fresenius Kabi®, Baxter® and Sandoz® intravenous nutrition on a guinea pig model._ In vitro studies; fatty acids oxidation and generation of toxic aldehydes. Development and validation of mass spectrometric method (Agilent series 1100 coupled with liquid chromatography, stable-isotope dilution)._ In vivo hepatic NF-kB quantitation (electrophoresis, Western Blot) and determination of pro-inflammatory cytokines mRNA transcription levels (RT-PCR, real-time qPCR). _ Pharmacokinetic; aldehydes DME by mass spectrometry (purification / extraction, GLP)

Pre-clinical advances in antioxidant / anti-inflammatory hexapeptide pharmaceuticals issued from breast milk, used as nutraceutics in parenteral nutrition.