Optimized antimicrobial combinations and their packaging in extracellular vesicles from soil bacteria, towards development of new antimicrobials to counter resistance

Novel antibacterial discovery and methods for treating recalcitrant bacterial infections.Publications:Imai, I*; Meyer, KJ*; Inishi, A; et. al. A new antibiotic selectively kills Gram-negative pathogens. Nature 2019 doi:10.1038/s41586-019-1791-1https://www.nature.com/articles/s41586-019-1791-1 Meyer KJ, Taylor HB, Seidel J, Gates M, Lewis K (2020) Pulse dosing of antibiotic enhances killing of a Staphylococcus aureus biofilm. Frontiers in Microbiology 11:596227. doi:… Show more Novel antibacterial discovery and methods for treating recalcitrant bacterial infections.Publications:Imai, I*; Meyer, KJ*; Inishi, A; et. al. A new antibiotic selectively kills Gram-negative pathogens. Nature 2019 doi:10.1038/s41586-019-1791-1https://www.nature.com/articles/s41586-019-1791-1 Meyer KJ, Taylor HB, Seidel J, Gates M, Lewis K (2020) Pulse dosing of antibiotic enhances killing of a Staphylococcus aureus biofilm. Frontiers in Microbiology 11:596227. doi: 10.3389/fmicb.2020.596227https://www.frontiersin.org/articles/10.3389/fmicb.2020.596227/fullO’Rourke A, Beyhan S, Choi Y, Morales P, Chan A, Espinoza J, Dupont C, Meyer KJ, Spoering A, Lewis K, Nierman W, Nelson K. (2020) Mechanism-of-action classification of antibiotics by global transcriptome profiling. Antimicrobial Agents and Chemotherapy doi 10.1128/AAC.01207-19 https://aac.asm.org/content/64/3/e01207-19Zong,Y; Fang, F; Meyer, KJ; Wang, L; Ni, Z; Gao, H; Lewis, K; Zhang, J; Rao, Y. Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics. Nat Commun 2019 10:3268https://www.nature.com/articles/s41467-019-11211-yZong, Y; Sun, X; Gao, H; Meyer, KJ; Lewis, K; Rao, Y. Developing Equipotent Teixobactin Analogues against Drug-Resistant Bacteria and Discovering a Hydrophobic Interaction between Lipid II and Teixobactin. J Med Chem 2018 61:3409-3421https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01241 Show less

Repurposing and optimizing Hsp90 inhibitors for use against the deadly parasite T. brucei.PublicationsMeyer KJ, Meyers DJ, Shapiro TA. Optimal kinetic exposures for classic and candidate antitrypanosomals. Journal of Antmicrobial Chemotherapy 2019. pii: dkz160. doi: 10.1093/jac/dkz160Meyer, KJ, Caton, E, Shapiro, TA. Model system identifies kinetic driver of Hsp90 inhibitor activity against African trypanosomes and Plasmodium falciparum. Antimicrob Agents Chemother 2018 doi:… Show more Repurposing and optimizing Hsp90 inhibitors for use against the deadly parasite T. brucei.PublicationsMeyer KJ, Meyers DJ, Shapiro TA. Optimal kinetic exposures for classic and candidate antitrypanosomals. Journal of Antmicrobial Chemotherapy 2019. pii: dkz160. doi: 10.1093/jac/dkz160Meyer, KJ, Caton, E, Shapiro, TA. Model system identifies kinetic driver of Hsp90 inhibitor activity against African trypanosomes and Plasmodium falciparum. Antimicrob Agents Chemother 2018 doi: 10.1128/AAC.00056-18Meyer, KJ, Shapiro, TA. Potent antitrypanosomal activities of heat shock protein 90 inhibitors in vitro and in vivo. The Journal of Infectious Diseases 2013 208:489-499http://jid.oxfordjournals.org/content/208/3/489.longOral presentationsMeyer KJ, Shapiro TA. RNAi of T. brucei cytosolic Hsp83 and mitochondrial TRAP-1 reveals roles for these Hsp90 homologues in cytokinesis and kinetoplast division. Kinetoplastida: Cellular, Molecular and Immunoparasitology Scientific Session. 64th Annual Meeting of the American Society for Tropical Medicine and Hygiene, Oct 25-29 2015, Philadelphia, PA (Co-chaired session)Meyer KJ, Shapiro TA. PK/PD of Antitrypanosomal Agents. Symposium on PK/PD for Neglected Tropical Infections. 55th Interscience Conference on Antimicrobial Agents and Chemotherapy, Sept 17-21 2015, San Diego, CA (Invited symposium speaker) Meyer KJ, Shapiro TA. Heat shock protein 90 (Hsp90) inhibitors have potent in vitro and in vivo activity against African trypanosomes. 23rd Molecular Parasitology Meeting, Sept 22-26 2012, Woods Hole, MA Show less

Drug discovery research investigating the mechanism of action of mycothiazole, a potent cytotoxic natural product from a sea sponge.Meyer KJ, Singh AJ, Cameron A, Tan AS, Leahy DC, O’Sullivan S, Joshi P, La Flamme AC, Northcote PT, Berridge MV, Miller JH. Mitochondrial Genome-Knockout Cells Demonstrate a Dual Mechanism of Action for the Electron Transport Complex I Inhibitor Mycothiazole. Marine Drugs. 2012; 10(4):900-917

Tutoring first year chemistry courses for students who desired extra assistance