Experienced Cell Biologist and Biochemist with a strong passion for research that can improve life quality for people with cancer and other chronic disease(s).PersonalityI´m known as a structured problem solver, driven by curiosity, professionalism, and a positive mindset. I see myself as a successful scientist, team player and research leader/supervisor that in addition to my professional qualities is in possession of an inclusive mindset, a good sense of humor and strong mental resources. MotivationMotivated by research projects with a clear goal to improve the life quality for people suffering from chronic disease(s). I see a great potential in genome editing technologies (CRISPR) that utilizes gene targeting through gRNA´s and Cas9 in its different flavours, e.g. the use “dead” Cas9 (dCas9) with fusion partners, that affects gene transcription through epigenetic mechanisms. I follow the development of novel delivery methods for either transgenes on plasmids, as stabilised mRNA´s or as recombinant proteins, using viral like particles, lipid nanoparticles and adenoviruses. I'm furthermore inspired by applications of PROTACS, "protein glues", chemo-proteomics and small molecules in drug development. BackgroundMany years of research experience in cell biology and biochemistry, that has evolved during my studies of cancer cells, stem cells and cells isolated from brain tissue in a mouse model of Parkinsons Disease. I obtained my PhD from the Ludwig Institute for Cancer Research in Uppsala, which was followed by a senior research position at the Danish Cancer Society, and later an employment as tenured group leader at the University of Copenhagen (BRIC) and the Finsen Insitute (Copenhagen Royal Hospital).Professional competencies• Advanced skills in cell based and biochemical assay development• Expertise in growing and differentiating embryonic and mesenchymal stem cells, and iPSCs• Expertise in gene delivery methods: lipid nanoparticles, electroporation and viral transduction• Hands on experience with genome wide technologies such as RNA- and ChIP-sequencing• Practical experience with mass spec based proteomics using diverse labeling techniques• Design and production of specific antibodies and numerous protein purification methods• Strong analytical and troubleshooting mindset
Self-Employed
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Research Consultant And EntrepreneurSelf-Employed Jan 2023 - PresentCopenhagen, Capital Region, Denmark
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Associate ProfessorBiotech Research And Innovation Centre, University Of Copenhagen And The Finsen Laboratory Jan 2021 - PresentCopenhagen Biocentre, Ole Maaløes Vej 5, 2200 N•Invited to become member of the well reputable Finsen Cancer Research Institute.•Beside my own projects focusing on drivers of tumor initiation (e.g. KLF4 mutant in meningiomas), I function as advisor on novel and ongoing cancer research projects in the Porse group, focusing on haematological cancers.•Our research projects uses genome wide analysis (RNA-seq, ChIP-seq, ATAC-seq etc) and proteomic approaches (MS analysis by SILAC and TMT labeling etc.).•We are currently implementing high-throughput single cell analyses for proteomics and genomics in our projects.•I design and produce highly specific antibodies for our research projects, including conjugation of small molecule markers.•We characterize and isolate cells using FACS analysis (e.g. establishment of cell clones).•I identify novel drivers of cancer initiation and progression, through data mining of public databases (e.g. Cosmic and DepMap).•We use epitope-tags in transgene expression for studies of protein-protein interactions by mass spectrometry.•We employ CRISPR-Cas genome editing for knock-out to study tumor growth in vitro and in vivo, and dCas9-KRAB-MeCp2-BSD and gRNA´s for gene silencing.
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Associate ProfessorBiotech Research & Innovation Centre (Bric), University Of Copenhagen May 2003 - Jul 2022Copenhagen, Capital Region, Denmark -
Group LeaderThe Biotech Research And Innovation Centre, University Of Copenhagen, Denmark May 2008 - Dec 2020Copenhagen, Capital Region, Denmark•After publication of one of my seminal works in Nature Cell Biology, I was given the opportunity to start my own research group at BRIC focusing on gene transcription, epigenetics and cancer. •Succeeded in getting renewal of the support from the Grundforskningsfonden for an additional 5 years (until 2017; in total support for 10 years). •Co-founder of the biotech company EpiTherapeutics Aps (2008), established based on patents, that I together with 4 colleagues had made possible due to groundbreaking research published in Nature in 2006, revealing KDM4C as a putative oncogene.•Major focus on chromatin modifying complexes as oncogenes or tumor suppressors, acting through epigenetic mechanisms, affecting gene expression and cell proliferation. E.g. the PRC2 complex, being the first to reveal, how, this enzyme complex through its binding to its own mark of methylation on chromatin (H3K27me3), maintain gene repressive domains during DNA replication to preserve cell identity; and how stress signaling counteract this maintenance of gene expression signatures and potentially leads to disease.•Identification of transcription factors as recruiters of PRC1 and PRC2 complexes with implications for gene expression changes in cancer.
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Associate ProfessorThe Biotech Research And Innovation Centre (Bric) May 2003 - May 2008Copenhagen, Capital Region, Denmark•Hired as the first associate Professor at BRIC in 2003, when Prof. Kristian Helin was appointed as Director of the Institute. •Strongly engaged in the establishment of the BRIC research center, and its daily operations the first year, while Prof Helin was still at IFOM in Milano.•In 2007, we were granted a major support from the Danish Grundforskningsfond for a Center of Excellence in Epigenetics, a grant application that I initiated, when working in Prof Helins laboratory as associate professor.
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Senior ResearcherDanish Cancer Society Jan 1996 - May 2003In charge of my own research activities. Supervisor for Master and PhD students. Raising money to projects by writing grant applications. Writing manuscripts. Major contribution to the understanding of retinoblastoma proteins as gatekeepers and tumor suppressors in cancer.
Klaus Hansen Education Details
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Growth Factor Signaling And Cancer -
Experimental Cell Biology
Frequently Asked Questions about Klaus Hansen
What company does Klaus Hansen work for?
Klaus Hansen works for Self-Employed
What is Klaus Hansen's role at the current company?
Klaus Hansen's current role is Talk about: Cell Biology l Biochemistry l Molecular Biology l Cancer Drivers l Stem Cell biology l Epigenetics l Cell Signaling l Genomics I Proteomics l CRISPR genome editing l Project management l cGMP I Leadership.
What schools did Klaus Hansen attend?
Klaus Hansen attended Uppsala Universitet, Syddansk Universitet - University Of Southern Denmark.
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Klaus Hansen
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