Leading a microfluidics team to develop internal high-throughput screening systems to accelerate natural strain improvement at hyperspeed for sustainable bioproducts including high quality food & nutrition, and better biologics.

Project: Automated Flow-Based and Digital Droplet Microfluidic Systems for Optimizing Biosynthetic Pathways • Developed high-throughput digital microfluidic platforms combined with flow-based microdroplet manipulation and integrated with fiber-based optical de-tection to automate CRISPR-based gene editing processes for pathway optimization. Project: Cooperative Development of a High Efficiency Anaerobic Electroporation Apparatus for Biofuel Generation from Waste Gases• Developed digital microfluidic platform for automated anaerobic transformation processes on a chip. (DOE TCF Project collaborated with LanzaTech) Project: High-Throughput Cell-Free Microreactor Platform for Optimization of Biochemical Pathways• Started a project to develop high-throughput microdroplet reactor platform for cell-free pathway optimization. (DOE TCF Project collaborated with LanzaTech) Project: Development of Digital Microfluidic Platform towards High-Throughput COVID-19 Diagnostics• Prototyped digital microfluidic platform to miniaturize the real-time RT-PCR assay used to detect COVID-19 to potentially increase sample throughput with reduced processing time and reagent usage compared to current CDC-approved assays.

Project: Vacuum-Based Microfluidic System for Point-of-Care Diagnostics• Consulted for the development of automated and low-cost nucleic acid testing microfluidic platform towards sensitive pathogen detection for primary-care clinics.

In the M3B Lab, we use mechanical engineering principles and micro/nanofabrication technologies to solve chemical and biological challenges, particularly in the areas of autonomous microfluidic cell/bead/droplet handling, drug delivery systems, cell mechanobiology, and integrated microfluidic circuitry.Project: "Magnetic Core-Shell Microcapsules for Therapeutic Delivery Applications"Engineered microparticles that carry aqueous/oil phase encapsulated by a magnetic shell for remote targeting and on-demand delivery of therapeutic agents

Project: "Finger-Powered Microfluidic Systems for Point-of-Care Diagnostics"Developed portable, low-cost, and easy-to-operate finger-powered pumps integrated with microfluidic chips for biomedical applications such as microdroplet generator and bead-based cystokine detection system. Project: "Continuous-Flow Microdroplet Rupture System"Created simple and rapid microfluidic system to passively rupture microdroplets and retrieve contents via micropost array railing process

Project: "Ingestible Sensor for Digital Health Feedback System"Investigated the performance of ingestible sensors, which is made of bio-compatible ingredients and powered by stomach fluid upon swallowing for transmitting signal from stomach to detect ingestions of medicines.

Project: "Dynamic Microarray Devices for Selective Arraying of Spheroids"Developed dynamic microarray devices for pairing, arraying and culturing two different types of cell spheroids (3T3 and HEP) to study interactions between cells

Project: "Niagara Foot Project"Tested mechanical cyclic fatigue of low-cost and functional prosthetic foot (Niagara Foot) for active individuals

Project: "Aseismic Design of Pipeline Systems for Power Plants"Optimized the design of pipeline systems in power plants to minimize the deformation from mechanical and thermal stimuli