Krati Sharma Email & Phone Number

United States

Nutraceutical profile and evidence of reduction in oxidative stress by high altitude (trans-Himalaya) inhabited Spirogyra porticalis. Human primary endothelial label-free biochip assay reveals unpredicted functions of plasma serine proteases.

United States

Project 1: Sanjhi Services PVT. LTDDeveloping and managing website, content management, planning, marketing, ad-designing and promotions and business developing strategies Project 2:Florida Technical University Acknowledged for providing computational support to a PhD student in study of Amyloid Beta against ABeta aggregationAuthored a chapter on NanobiotechnologyAuthored a chapter on “Novel Nanomaterials for Drug Delivery” accepted by Springfield. Project 3: Colgate, Palmolive PUBLICATION: Professional - Grade TCA-Lactic Acid Chemical Peel: Elucidating Mode of Action to Treat Photoaging and HyperpigmentationProject 4: Rare Genomics Institute Pipeline for genetic mapping and variant callingPredicting deleterious mutations in contrast to symptoms of patientsPulling data from the API (API integration), working with cell-lines from TCGA, Cbioportal, NK-cell likes 3D protein model generation with SNP to predict effected pathways Assisted pipeline development for finding Copy Number Variation detection in EXOME data. Raw NGS Data Quality control, alignment with reference genome, alignment QC, quantification, mutational detection, fusion detection Assisted project "Professionally Guided Wikipedia development" with the Rare Disease Common team (Rare Genomics Institute) with support of Watson Research Group of IBM.

Greater Philadelphia Area

Supporting Biomarker discovery, translational research and personal genomics research projectsProviding support to global Merck research Scientists, clinical specialists, IT solution and information security departments, and IT system vendors to define IT solutions that would enable Biomarker and Translations researchPlanning and migrating all existing components available in existing legacy system to the new environment Performing end-to-end analysisExtensive troubleshooting of pipelines, improvising workflowTracking data influx to predict business needs and refining resources Plotting data influx trends in R (past, present to improvise future needs) Acted as liaison between different groups within the organization IT, stakeholders, data engineers Assist in data analysisContribute in designing, assisting upgrades of robust workflows as well as writing scripts as needed Data acquisition and management Providing cloud computing support Upgrading and creating gene models/genome referencesProject management on JIRA, Merck internal databases tracking and documentationWorking in agile, waterfall and hybrid architecture

Greater Philadelphia Area

Molecular modelingMolecular simulationsProtein-protein, Protein-DNA, Protein-Ligand dockingEnergy minimization and free energy calculationsWorking with the AMBER16/CHARMM/YASSARA/Rosetta, OpenEye/Babel softwareSimulations in presence of water/metals(Zn and Mg) and in absence of water /in presence metals (Zn and Mg)Training and testing models to gain confidenceStudy correlations and other statistical methods to gain confidence on trained datasetClustering of the data (PCA, K-mean, DBScan)Evaluate, install, and maintain software packages for the laboratory/cloud cluster@FCCC.Supporting installation/Licensing for the software and research fund writing R studio for, Pymol, Chimera, VMD for visualisationsTest and benchmark application packages on different hardware and software platforms

Developed front-end and back-end web sever application for protein-ligand docking, developed and maintaining database, currently holding 4000 protein structures generated using molecular modeling, validated docking algorithm

Jodhpur Area, India

Combined all functionalities into the four working webservers 1. To get interface residues2. Docked proteins3. Energy minimization4. PDB file to sequence format Web applications development in PHP/PERL, Database management skills SQL/MySQL, software development support to research laboratories. Statistics reporting, keeping abreast with researchers for big data analysis, sequence parsing, develop routines for data mining and extractions, software installation support on Virtual machines and in house systems, source codes automation, string handling and manipulation using scripts and Linux, daily statistics generation and its online submission. I have also written technical white paper for FDA clearance of medical devices for Johari Digital Healthcare LTD.

India

Developing white paper for FDA approval of the medical and healthcare electromechanical devices Running case studies on patients to understand role of therapeutic wavelengths(TNS, Ultrasound, RF)Developing case studies for FDA approval given the FDA guidelines and cGMP regulations Licensing, patent regulations and certifications (ISO/BIS)Helping marketing team in promotional materials and campaigns for international events Recording advertisements for Wellness Spa and ClinicProcessing leads to assist sales team domestic and international

New Delhi Area, India

Dimer generation using a given monomer of a protein under supervision of Prof B. Jayaram. Generation of translation/ rotation matrices, developing algorithm to find interfaces/ binding sites, finding parameters for interface residues, scoring function for parameters, protein designing.After the project completion, I have been involved into independent research. I automated source code and scripts for developing four working webservers which will be published on my website- www.biologicalstructure.comTools Amber8/11Language CScript Bash/PHP6Database MySQLScript BASH/Perl

Master Of Science - Ms, Bioinformatics, 3.41/4.00

Project Description - RGC_ANPRA and OTHER_SBK3 Kinase study to generate 3D models using different approaches and ranking models based.

Master Of Science (M.Sc.), Bioinformatics, 3.78/4.00

Activities and Societies: Class and Placement representatives, Organized and participated in cultural activities, debate competitions.

Bachelor Of Science (B.Sc.), Biotechnology, 3.75/4.00

Activities and Societies: Cultural ActivitiesCourses taken are Recombinant DNA Techniques, molecular biology, microbiology, biophysics.