Kristina Cunningham Email and Phone Number
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SUMMARY STATEMENTProtein biochemist and technical leader with eight years of pharmaceutical experience in small molecule and biotherapeutic drug discovery. Expertise in the application of biochemical, biophysical, and enzymological techniques needed to characterize and advance targets. Experience with managing teams of doctoral and associate scientists. Interested in using analytical, scientific, and leadership skills to advance and lead projects. HIGHLIGHTS• Expertise in biochemical and biophysical evaluation of proteins using isothermal titration calorimetry, fluorescence polarization, multi-angle light scattering, circular dichroism, preparative and analytical HPLC, and surface plasmon resonance.• Proficient in enzyme kinetics, promoting full characterization and mechanistic evaluation of purified enzymes.• Develops HTS assays using fluorescence intensity, AlphaScreen, FRET, TR-FRET (LANCE, Lantha), DELFIA, and spectrophotometric methods, utilizing robotics.• Supervisor of highly-productive teams of Ph.D. and M.S. scientists.• Talent for prioritizing objectives, collating and organizing data, meeting deadlines, and presenting to high level management.• Collaborator with multiple disciplines in the early and late stages of drug discovery, including medicinal chemistry, protein purification, structural biology, and computational chemistry.• Solid leadership, team management, interpersonal, and communication skills.• Proven problem solver using innovative thinking and application of cutting-edge techniques.
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Biochemical Scientist Principal ConsultantEmd Millipore Sep 2011 - PresentBedford, Ma• Leading a seven-person bioanalytical group which is responsible for a wide variety of bioanalytical and biophysical methods for the characterization of biomolecules. • Capabilities include protein quantification and characterization, quantification of residual host cell protein and nucleic acid impurities, aggregate characterization, protein engineering, and protein stability. • Responsiilities include evaluation of new technologies that will increase the lab's capabilities or throughput to support Process Solutions research into products that enables pharmaceutical and biotechnology companies to develop and manufacture clinical and commercial drug materials safely and efficiently.
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Senior Principal ScientistPfizer Mar 2010 - May 2011Cambridge, Ma• Built and established infrastructure for a protein engineering, expression, purification, and characterization group charged with providing quality peptide therapeutic reagents for the treatment of diabetes and obesity.• Collaborated with molecular modelers and biologists to select peptides with potent dual activity on class B GPCRs in cell-based assays for half-life extension through bioconjugation to Fc. -
Senior Research Scientist Ii, Department Of Chemical And Screening SciencesWyeth Research Jan 2006 - Dec 2009• Coordinated hit and lead characterization and HTS assay development efforts for ten projects in Inflammation, Metabolic Disease, and Tissue Repair Departments.• Created orthogonal biochemical and biophysical assays to support hit-to-lead and lead optimization efforts through potency (IC50s, Kis), reversibility, mode of inhibition, and time dependence studies to encourage data-driven decisions.
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Sr. Research Scientist I, Department Of Biological ChemistryWyeth Research Aug 2002 - Dec 2005• Developed novel fluorescence polarization assays in collaboration with medicinal and computational chemists for six projects to provide mechanism of action and binding constants to direct the selection of small molecules for crystallization and animal studies.• Applied Isothermal Titration Calorimetry to obtain stoichiometry, dissociation constants, and thermodynamic parameters for small molecule, protein:protein and protein:peptide projects.• Fully characterized purified enzymes (Km, kcat, active site titration, stability) and substrate specificity of protease, phosphatase, and kinase projects.
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Post-Doctoral FellowHarvard Medical School, Department Of Microbiology And Molecular Genetics Mar 1999 - Jul 2002Postdoctoral Fellow with Dr. R. John Collier studying structure and function relationship of Anthrax Toxin. • Defined ligand binding site on Anthrax Toxin's oligomeric protective antigen using protein engineering, biochemical and cell-based techniques.• Determined ligand stoichiometry in Anthrax Toxin complex by capillary electrophoresis and SEC-MALLS.
Kristina Cunningham Skills
Kristina Cunningham Education Details
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Biochemistry
Frequently Asked Questions about Kristina Cunningham
What company does Kristina Cunningham work for?
Kristina Cunningham works for Emd Millipore
What is Kristina Cunningham's role at the current company?
Kristina Cunningham's current role is Biochemical Scientist Principal Consultant at EMD Millipore.
What is Kristina Cunningham's email address?
Kristina Cunningham's email address is kr****@****hoo.com
What is Kristina Cunningham's direct phone number?
Kristina Cunningham's direct phone number is +178153*****
What schools did Kristina Cunningham attend?
Kristina Cunningham attended The Johns Hopkins University, Wellesley College.
What skills is Kristina Cunningham known for?
Kristina Cunningham has skills like Protein Chemistry, Assay Development, Drug Discovery, Bioanalysis, Cell, Protein Purification, High Throughput Screening, Purification, Collaboration, Communication, Protein Characterization, Biophysics.
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