Dr. Sandeep Kumar Email and Phone Number
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I am an Indian-American scientist interested in discovery and development of novel biotherapeutics that benefit the patients with unmet medical needs. I am passionate about using science and technology to mitigate challenges towards bringing biotherapeutics to market faster, more often, and at affordable costs. I am using my expertise in computational biology, bioinformatics, computational biophysics, and data science to promote biopharmaceutical informatics, in silico developability assessments, and digital transformation in Biopharmaceutical Industry. In particular, I have come up with a strategic vision, Biopharmaceutical Informatics. Biopharmaceutical Informatics calls for syncretic use of Computational Biophysics, Biomolecular experiments, Information technology, and AIML towards improving the productivity of biologic drug discovery and development projects. In recent years, Biopharmaceutical Informatics has emerged as a field on its own. I have so far contributed more than 100 publications that have received more >11500 citations (h-index = 48; i10-index = 88; 26 cited >100 times and 1 with >1100 citations) and edited one book entitled "Developability of Biotherapeutics: Computational Approaches" (Please see featured weblinks for more information). I have recently finished editing another one entitled "Biopharmaceutical Informatics: Learning how to discover developable biotherapeutics". This book is currently in production. I have mentored numerous graduate students, postdoctoral fellows, and colleagues in biopharmaceutical industry. I am also experienced at recruiting, supervising, and nurturing talent. I am particularly adept at leading cross-functional and international teams and forging academic-industry collaborations.I am an associate Editor for mAbs, a Taylor & Francis Journal and a frequently invited speaker at the conferences in biopharmaceutical industry.In summary my professional experience, since completing doctorate, consists of approximately 27 years in Government, Academia and Industry.
Naturalantibody
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- naturalantibody.com
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Senior Vice President For Digital BiologicsNaturalantibodyBridgewater, Ma, Us -
OwnerSkumar Biotech Advisory LlcBoston, Ma, Us
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Distinguished Fellow (Executive Director), Head Of Molecule Design And ModelingModerna Jun 2023 - PresentCambridge, Massachusetts, Us• Building Computational Molecule (DNA, RNA and Protein) Design and Modeling group. Leading a team of 13 highly talented scientists. Initial focus areas of the group include protein (antibodies, enzymes, vaccine) design and engineering, in silico discovery of antibodies and TCRs, mRNA design and Prime editing. Other responsibilities remain the same as below. • Advocating for Digital transformation of biotherapeutic lab practices and workflows.• Successfully led a team to generate de novo antibodies with desirable developability profile and tested them via experimental protein production and analytical characterization, using the philosophy of Turing imitation game. The AI-generated antibodies show experimental developability attributes similar to those of the antibodies currently in the market and NIST reference mAb. • This paradigm shifting technology can potentially expand the antigen space druggable by the antibody-based modalities in addition to improving the productivity of biotherapeutics drug discovery and development cycles. -
Distinguished Research Fellow (Biotherapeutics) And Group LeaderBoehringer Ingelheim Apr 2021 - Jun 2023Ingelheim Am Rhein, Rhineland-Palatinate, DeIn addition to the activities in the previous role, I am now involved in leading BI's postdoctoral program at Ridgefield. I am also leading digital transformation of Biotherapeutics Discovery, and scientific as well as leadership aspects of in silico Ab discovery. -
Senior Research Fellow (Biotherapeutics) And Group LeaderBoehringer Ingelheim Jan 2018 - Mar 2021Ingelheim Am Rhein, Rhineland-Palatinate, DeBuilt a group called Computational Biochemistry and Bioinformatics (CBB) from scratch: CBB is supporting all aspects of biologic drug discovery, design and optimization and is collaborating closely with our colleagues in early stage drug development. These include antigen optimization, recovery of antibody variable genes via Sanger and Next Generation Sequencing, epitope / paratope mapping, design of antibody libraries, antibody humanization and affinity maturation, lead candidate optimization for appropriate potency as well as developability. CBB also supports structural modeling and design of novel multi-specific biologic modalities, computational prediction of immune epitopes, statistical data analyses including machine learning and artificial Intelligence. Leading Digital transformation of Biotherapeutics Discovery: I am currently formulating digital strategy my department and have led development of prototype version of Developability Navigator, a computational tool to guide selection and rational optimization of biologic drug candidates starting with antibody hit selection to lead identification, optimization, and recommendation of final candidate(s) for development. Co-leader of cross-functional in silico team that consists of colleagues from biotherapeutics discovery and development. Member of Research Informatics Council: This is a global governing body that prioritizes the budgetary funding for Information Technology Department of Boehringer Ingelheim. Currently job shadowing for Coordinator for Boehringer Ingelheim’s global postdoc Program; will take charge in Summer 2022.Academic Collaborators: Prof. Peter M. Tessier (Univ. of Michigan), Prof. Michael M. Gromiha (IIT-Madras), Prof. Charlotte M. Deane (Univ. of Oxford), Prof. Bernhardt Trout (MIT) and Dr. Janice Reichert (Antibody society, mAbs).Contributed towards discovery and optimization of several biologic drug candidates currently in Clinic. -
Senior Principal ScientistPfizer May 2012 - Dec 2017New York, New York, UsHead of Molecular Modeling, Simulations & Data Analyses Center of Emphasis within Formulation Process Development (FPD) groupWhile at Pfizer, I Led computational efforts towards modeling and design of bio- therapeutics in Biotherapeutics Pharmaceutical Sciences R & D. Structure based biologic drug design. Antibody engineering. Fundamental biophysics oriented computational research in biologic drug product degradations including aggregation. Homology model building of full length mAbs and antibody based therapeutics, fusion proteins, antibody drug conjugates and novel entities. Modeling, simulations and aggregation prediction directed at improving solubility at high concentrations, cell line expression and manufacture-ability of bio-therapeutics. High performance computing (HPC). Studying couplings among structure -- function, aggregation and immunogenicity in biotherapeutics. Antibody and protein structure-function relationships. Supporting computational aspects of biotherapeutics and vaccine formulation projects. Collaborating with early discovery scientists to help bring forward more candidates with improved manufacturability. High performance computing for biotherapeutics research. Helping development of data storage solutions for biotherapeutics. Forging Academic and Industrial collaborations. Mentor Postdoctoral fellows and scientists.External publications since joining Pfizer: 40. External invited talks: ~30. External symposium poster presentations: 10. -
Principal ScientistPfizer May 2007 - May 2012New York, New York, UsStarted and lead computational efforts towards modeling and design of bio- therapeutics in Biotherapeutics Pharmaceutical Sciences R & D. Structure based biologic drug design. Antibody engineering. Carried out fundamental biophysics oriented computational research in biologic drug product degradations including aggregation. Homology model building of full length mAbs and antibody based therapeutics, fusion proteins, antibody drug conjugates and novel entities. Modeling, simulations and aggregation prediction directed at improving solubility at high concentrations, cell line expression and manufacture-ability of bio-therapeutics. High performance computing (HPC). Studying couplings among structure -- function, aggregation and immunogenicity in biotherapeutics. Antibody and protein structure-function relationships. Provided computational support for biotherapeutics and vaccine formulation projects in development stages. Collaborated with early discovery scientists to help bring forward more candidates with improved manufacturability. High performance computing for biotherapeutics research. Forged Academic and Industrial collaborations. Mentor Postdoctoral fellows and scientists. -
Associate Research Scientist / Research Assistant ProfessorJohns Hopkins University Jan 2005 - Apr 2007Baltimore, Md, UsMy work involved structure based small molecule drug design. I used Fragment based lead generation for discovery of highly potent and selective small molecule therapeutics for several target serine proteinases and receptors involved in Cardiovascular diseases, such as diabetes, cancer and antibiotic resistance. I also performed fundamental research in protein structure—function and published 2 research articles. -
Assistant ProfessorIndian Institute Of Technology, Kanpur 2004 - 2004Kanpur, Up, InActed as Group leader and as an administrator.Advised two graduate students.Conducted research in protein structure—function. Taught a shared course in bioinformatics and computational biology at graduate level. Submitted several grant applications and obtained funding.Published scientific papers. -
Assistant Professor (Research Track)Georgetown University Medical Center Jan 2003 - Dec 2003Washington, Dc, UsDeveloped standard operating rule-based procedures for annotation (curation) and propagation functional information in PIRSF and UniProt Protein sequence families, Conducted research in protein sequence—structure—function relationships and published scientific papers. Advised one graduate student. -
Postdoctoral Visiting ScientistNational Cancer Institute Jul 1999 - Dec 2002Bethesda, Md, UsAdvisor: Prof. Ruth NussinovFundamental computational biophysics and bioinformatics research was carried out in several aspects of protein sequence - structure - function relationships including protein electrostatics, protein folding and binding, thermo stability, molecular recognition, and molecular evolution.Published 30 research papers, review articles and book chaptersAdvised a graduate student. Presented the research work in scientific meetings and conferences. -
Postdoctoral ScientistSaic Frederick Jan 1998 - Jun 1999Advisor: Prof. Ruth NussinovFundamental computational biophysics and bioinformatics research was carried out in several aspects of protein Sequence-structure-function relationships including protein electrostatics, protein folding and binding, thermo stability, molecular recognition, and molecular evolution. This position was co-joined with my NCI-Frederick Postdoc. I worked in the same research group.
Dr. Sandeep Kumar Education Details
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Iese Business SchoolExposure: Global Leadership -
Indian Institute Of Science (Iisc)Computational Molecular Biophysics; Bioinformatics; Protein Structure-Function -
G. B. Pant University Of Agriculture & TechnologyMolecular Biology And Biotechnology -
Delhi UniversityPhysics
Frequently Asked Questions about Dr. Sandeep Kumar
What company does Dr. Sandeep Kumar work for?
Dr. Sandeep Kumar works for Naturalantibody
What is Dr. Sandeep Kumar's role at the current company?
Dr. Sandeep Kumar's current role is Senior Vice President for Digital Biologics.
What is Dr. Sandeep Kumar's email address?
Dr. Sandeep Kumar's email address is bh****@****hoo.com
What is Dr. Sandeep Kumar's direct phone number?
Dr. Sandeep Kumar's direct phone number is .212.733*****
What schools did Dr. Sandeep Kumar attend?
Dr. Sandeep Kumar attended Iese Business School, Indian Institute Of Science (Iisc), G. B. Pant University Of Agriculture & Technology, Delhi University.
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