Luke Yongkyu Kwon Email and Phone Number

STTARR Innovation Centre at the University Health Network (UHN) is one of the largest pre-clinical imaging facility in North America which brings together products, services, and technologies to accelerate cutting-edge and multidisciplinary research in oncology, cardiology, metabolic diseases, and many other fields. STTARR's advanced imaging instruments and experimental capabilities include CT, MR, PET, SPECT, ultrasound, photoacoustic, optical, and radiation therapy.My responsibility as a scientist at STTARR facility is to provide a full support in research involving synthesis and optimization of radiopharmaceutical for pre-clinical imaging or radioimmunotherapy. A full support implies from study conception to completion, including study design, budgeting, federal and provincial regulatory compliance, imaging/data analysis, and study report. Our client not only includes academic users from the University of Toronto or University Health Network but also industry clients (i.e. biopharmaceutical or radiopharmaceutical companies).

Radiochemical and Analytical Researcher at Royal Military College (RMC)

Thesis Title: Positron Emission Tomography (PET) of Breast Cancer Heterogeneous for HER2 and EGFR using Bispecific RadioimmunoconjugatesThesis Supervisor: Dr. Raymond Reilly

PHC300H1/PHM322H1 Molecular Pharmacology I Course Description: Structural and mechanistic determinants of drug action at the molecular level. Topics include the physical-chemical properties of drugs per se as they relate to therapeutic intervention and the biophysical and biochemical properties of enzymes and nucleic acids that underlie and are affected by their interactions with drugs.

PHC301H1/PHM140H1 - Molecular Pharmacology IICourse Description: Many drugs act via the receptors and other proteins that mediate cellular signalling. Such signalling proteins can be grouped into several families on the basis of their structural and functional similarities. Examples from each family are examined at the molecular level from a pharmacological, biochemical and biophysical point of view for insight into their structure, their mechanism of action, their modulation by drugs and the underlying dysfunctions toward which the drugs are directed. Basic principles of molecular pharmacology are introduced as a tool for decoding the relationship between dose and response across all families, with an emphasis on the explicit nature of concepts such as potency and efficacy.

PHC230H1/PHM141H1 - Pharmaceutics ICourse Description: Achieving effective treatment of a disease while minimizing adverse effects of a drug requires rational selection, formulation and administration of an appropriate dosage form. This course teaches the scientific background and technical aspects important in dosage form design and their therapeutic applications. This course will focus on the biopharmaceutical considerations and physiochemical foundation of various dosage forms. Discussion will include preformulation factors (melting point, solubility, viscosity, dissolution, particle and solid state properties), rheology, pharmaceutical solutions, pharmaceutical powders, colloids and dispersions, complexation chelation, and protein binding.

UTKGPSA's mission is to encourage inter-division communication between Korean post-undergraduate students across University of Toronto and promote solidarity through academic and social events.UTKGPSA also aims to provide support and resources for current and prospective students who wish to pursue graduate/professional degrees at UofT.Anyone who is pursuing a master's, a Ph.D, or a professional degree at UofT is welcomed to join our group!Link: https://www.facebook.com/groups/utkgpsa/

Responsible for detecting dimerization of two human epidermal growth factor receptors (HER2/EGFR) in breast cancer cell lines using western blot and co-immunoprecipitation. Examination of effect of radioimuunoconjugate probe on formation of dimers and downstream signalling.; Determination of both in vivo and in vitro dose enhancing ability of gold nanoparticles upon X-ray irradiation against breast cancer.

I learned the knowledge of the biological, medical and physical sciences in the study of the scientific aspect of drug therapy. In addition, I received a solid background in physical, organic and analytical chemistry, and learned the fundamental aspects of the synthesis, manufacture, use and mode of action of drugs

In Vitro Cytotoxicity Study of HER-2-Targeted Gold Nanoparticles for Dose-Enhancement Enhancedof X-radiation Treatment against of Locally Advanced Breast Cancer

Assisted in calculating subcellular dosimetry of Copper-64 using Monte Carlo N-Particle Computer Code. Fourth-Year Research StudentSeptember, 2010 – April, 2011