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Kyle Lefkoff, 65, is the Founder and General Partner of Boulder Ventures Ltd. In his 39 years as a venture capitalist, Mr. Lefkoff has invested in 64 Colorado companies.Mr. Lefkoff’s life science investments include Hauser Chemical Research (NASDAQ: HAUS); NeXstar Pharmaceuticals (sold to Gilead Sciences), Array BioPharma (sold to Pfizer), Dharmacon (sold to Fisher Scientific), Genomica (sold to Exelixis), miRagen Therapeutics (NASDAQ: MGEN), ArcherDX (sold to Invitae), Mineralys (NASDAQ: MYLS), and Ambrosia BioSciences.His information technology investments include McData (sold to EMC); Atlantes Corp. (sold to Metromail); Compatible Systems Corp. (sold to Cisco Systems); Wall Street on Demand (sold to Goldman Sachs), Lefthand Networks (sold to HP), LineRate Systems (sold to F5), and Black Bear Energy (sold to Legence).Mr. Lefkoff founded Array BioPharma in May, 1998 with Marv Caruthers and a group of Amgen scientists. Mr. Lefkoff was the Chairman of the Board of Array from its inception through August 2018, when Array's first cancer drug was approved by the FDA. In July, 2019, Array was acquired by Pfizer for $11.8 Billion in cash, the largest acquisition of a venture-backed life sciences company in the history of Colorado.Mr. Lefkoff received his B.A. in Economics from Vassar College (summa cum laude) in 1981. In 1980, Mr. Lefkoff completed a Fellowship in Economic History at the London School of Economics. In 1985, he completed his MBA in Finance at the University of Chicago.An experienced alpinist and mountain guide, Mr. Lefkoff is the Founding Chairman of the American Institute for Avalanche Research and Education (AIARE), the avalanche education standard among mountain guides and snow professionals in the USA. He was a member of the 1986 American Expedition to the North Face of K2.
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General PartnerBoulder Ventures 1995 - PresentBoulder, Co, UsMr. Lefkoff founded Boulder Ventures Ltd. in 1995 to make venture capital investments in technology and life sciences companies in Boulder, Colorado.Mr. Lefkoff has been the General Partner of eight Boulder Ventures funds over the past thirty years. -
Chairman Of The Board And FounderAmbrosia Biosciences Inc. Mar 2024 - PresentBoulder, Co, UsAmbrosia is a drug discovery company developing orally delivered, small molecule-based therapies for obesity and other metabolic disorders. -
Board Member And Lead Venture Capital InvestorBlack Bear Energy Inc. Jun 2016 - Jun 2024Boulder, Co, UsMr. Lefkoff led the Series A round of investment for Black Bear Energy in June 2016 and served on its Board of Directors. In July 2022, Black Bear Energy was sold to Legence in a cash transaction that included a 2023 earnout. Mr. Lefkoff then acted as the Shareholder's Representative for former Black Bear Energy shareholders and collected the full earnout from Legence in June 2024. -
Founding Chairman Of The BoardAiare- American Institute For Avalanche Research And Education Mar 2013 - Jun 2023Mr. Lefkoff was asked by AIARE's founder, Tom Murphy, to form a professional outside Board for this non-profit organization whose mission is to save lives through avalanche education.Mr. Lefkoff served as AIARE Chairman for ten years, and recruited Jason Fields to succeed him in 2023.Today, AIARE is the certification standard for snow-safety professionals in the US, and its recreational curricula is used by AIARE educators to teach avalanche safety to more than 20,000 backcountry users each year. -
Board Member And Lead Venture Capital InvestorInvitae Mar 2018 - Mar 2023San Francisco, Ca, UsMr. Lefkoff co-led the Series A round of investment in ArcherDX with Paul Manning in March 2018, and joined the ArcherDX Board of Directors as Chairman. He then co-led the Series B round with Mr. Manning in May 2019 and helped recruit Steve Kafka to replace him as Chairman of the Board. ArcherDX was acquired by Invitae in June, 2020 for $1.4 billion in cash and stock. Mr. Lefkoff became the Shareholder's Representative for the former ArcherDX shareholders, and helped secure an additional $1 billion of Invitae shares as earnout consideration.ArcherDX is the largest exit of a venture backed life sciences tools company in the history of Colorado. -
Chairman Of The Board And FounderArray Biopharma Jan 1998 - Aug 2018Boulder, Co, UsMr. Lefkoff founded Array BioPharma in May, 1998 with Marv Caruthers and a group of Amgen scientists. Mr. Lefkoff was the Chairman of the Board of Array from its inception through August 2018, when he recruited Carrie Cox to take on the Chairman’s role. In that time, Array discovered and developed 24 kinase inhibitors for cancer, inflammation and heart disease. In June, 2018, Array’s targeted therapy for melanoma was approved by the FDA. In July, 2019, Array was acquired by Pfizer for $11.4 Billion in cash, the largest acquisition of a venture-backed life sciences company in the history of Colorado. -
Board Member And FounderMiragen Therapeutics, Inc. 2007 - 2017Waltham, Massachusetts, UsMr. Lefkoff incubated miRagen in the offices of Boulder Ventures with our EIR, Dr. Bill Marshall, who was CEO of BV portfolio company Dharmacon.Mr. Lefkoff co-led the Series A round of miRagen with Atlas Venture, and served on the miRagen Board with Bruce Booth and Marv Caruthers through the Company's IPO in 2017. -
Former Member Of The Board Of DirectorsTrust Company Of America 1999 - 2014Centennial, Colorado, Us -
Lifetime Member, Former Board Member And TreasurerAmerican Mountain Guides Association 2001 - 2010Boulder, Co, Us -
General PartnerColorado Venture Management, Inc 1986 - 1995One of the two original venture capital firms in Boulder, Mr. Lefkoff managed four funds, CVM Equity Fund I, II, III and IV.
Kyle Lefkoff Education Details
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The University Of Chicago Booth School Of BusinessGeneral -
Vassar CollegeEconomics
Frequently Asked Questions about Kyle Lefkoff
What company does Kyle Lefkoff work for?
Kyle Lefkoff works for Boulder Ventures
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Kyle Lefkoff's current role is General Partner, Boulder Ventures Ltd..
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What schools did Kyle Lefkoff attend?
Kyle Lefkoff attended The University Of Chicago Booth School Of Business, Vassar College.
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