Kyle Bowler Email & Phone Number

Morrisville, NC, US

East Rutherford, New Jersey, US

• Execute analytical methods under cGMP guidelines and provide analytical support to testing of drug substances
• Participate in experimental design, including development of methods and testing requirements to demonstrate method suitability
• Assist with writing standard operating procedures, methods, qualification protocols and other standard documents
• Strong understanding and proficiency in use and maintenance of instrumentation, equipment, and scientific methodologies
• Compile, maintain, and interpret analytical data, and effectively communicate results
• Assist with writing technical documents such as OOS, atypical investigations, deviations and CAPAs

Stockholm, Stockholm County, SE

• Independently and proficiently characterizes inhalation products via routine cGMP assays (e.g., HPLC, LC-MS, KF, FTIR)
• Clearly captures documentation according to GMP regulation and reports experimental results for advanced techniques
• Possesses a thorough understanding of the theory and technical principles behind tests and reliably troubleshoots instrument issues
• Authors and reviews protocols, methods, API safety guidelines, deviations, investigations, invalid events, and validation test cases
• Regularly assists inhalation group with non-GMP sample manufacturing, preparation, and analysis for R&D purposes
• Manages the 5S compliance of the glassware and preparation laboratory spaces through weekly evaluations and cleaning

Philadelphia, Pennsylvania, US

• Independent scientist demonstrating proficient technical knowledge and strong supervisory skills of Virology testing operations
• Directs and reviews routine In Vitro assays comprised of test article inoculation, media feeds, passage(s), and hemadsorption and/or hemagglutination endpoints
• Verifies atypical cell observations and authors/reviews scientific investigations and nonconformances
• Evaluates assay validity for key negative (virus-free) and positive (virus-inoculated, cytopathic effect-expected) cell line controls
• Ensures testing conformance to controlled documents, applicable regulations, and directives (e.g., GMP, client request, SOPs)
• Demonstrates strong oral and written communication skills and prepares/revises technical CoA reports for issuance

Wilmington, NC, US

• Possesses a thorough understanding of laboratory procedures and can reliably and independently conduct complex analysis
• Leads authorship of scientific documents and quality records for the team, including Investigations, Nonconformances, and CAPAs
• Participates in method and protocol revision, and performs secondary quality review of release and stability reports prior to issuance
• Troubleshoots and performs root cause analysis to resolve complex assay or instrumentation issues
• Mentors and trains analysts on technical methods (e.g., HPLC, CE, Empower), and assists others in troubleshooting analytical issues
• Hosts team-wide training seminars on various technical subjects such as software use, client LIMS data entry, and secondary review

Wilmington, NC, US

Joined the PPD Ambassador Program to promote awareness of PPD's mission and goals. This program connects prospective student candidates with PPD employees to have transparent conversations about a day in the life of their role, life after graduating, and company culture.PPD is a leading global contract research organization providing comprehensive drug.

Wilmington, NC, US

• Performed release and stability analytical testing of biopharmaceuticals for several diverse client programs under GMP conditions
• Proficient in chromatographic and electrophoretic techniques which evaluate quality and stability at various stages of development
• Conducted secondary quality review of scientific results and sample-level testing against controlled documents and client directives
• Took leadership by training analysts on technical methods (e.g., HPLC, CE, Empower) and mentoring four new employees
• Fostered collaboration and teamwork by assisting in troubleshooting analytical or instrumental issues and remaining positive
• Served on an internal focus team to develop and optimize a lab bench reservation tool for compliance with social distancing

Chapel Hill, NC, US

• Cheminformatics and Molecular Modeling: Funded as a graduate student research assistant with Dr. Alexander Tropsha in the Molecular Modeling Laboratory and predicted in vitro biochemical activities of drug-like small.
• Employed best practices in experimental data collection, classification, and curation, descriptor calculation, and statistical modeling
• Trained binary QSAR models for major specific endpoints of chemogenomic assay interference
• Communicated project details in status meetings weekly with lab coauthors and monthly with Dr. Tropsha
• Defended thesis on cheminformatics analysis and modeling of small molecule colloidal aggregates, which cause detergent reversible protein sequestration and are the most prevalent source of nonspecific activity in.
• Hosted two department-wide research seminars and presented research or relevant literature at lab meetings twice each semester

Chapel Hill, NC, US

• Prepared and hosted three-hour weekly breakout sessions with didactic a¬nd applied components to a class of eight graduate students
• Engaged students to develop a functional understanding of Computer-Aided Drug Discovery via statistical modeling, virtual screening, and docking simulations with in-class examples and a final project related to GPCR or.

New York, New York, US

• Examined the concordance of the high-speed ANAKIN-ME-1x (ANI) deep learning ab initio potential against popular molecular- and quantum-mechanical potentials for drug-like small molecule 3D conformers to benchmark the.
• Fostered collaboration between Pfizer’s Computational Chemistry groups at La Jolla, CA and Groton, CT, and the universities of North Carolina and Florida by facilitating twice-monthly WebEx conferences between.
• Demonstrated that ANI has high correlation to the MP2 and DFT ab initio calculations and appreciates the anomeric effect
• Presented major findings to the Pfizer Computational Chemistry division at La Jolla, CA and published an internal work summary
• Integrated ANI into Pfizer computing infrastructure via Python scripts implemented through the Bash Unix shell

Athens, GA, US

• Glycan Biochemistry and Enzymology: Funded as an honors undergraduate research assistant with Dr. Maor Bar-Peled in the Complex Carbohydrate Research Center and employed techniques in cloning, protein purification.
• Identified the functionality of nucleotide-sugar biosynthetic genes in pathogenic Bacillus bacteria and Botrytis fungus
• Discovered and characterized enzymes encoded in B. thuringiensis which dehydrate UDP-GlcNAc in a two-step mechanism
• Demonstrated that the accumulation of the dehydrated UDP-glucose intermediate in the UDP-Rhamnose synthetic pathway of B. cinerea and V. dahliae obstructs cellular pathogenicity and growth and may be a lead for the.
• Presented a research abstract and poster at the Center for Undergraduate Research Symposium
• Instructed incoming undergraduate and graduate students on laboratory procedures and protocols as Education Program Specialist

Master Of Science - Ms, Pharmaceutical Sciences

Graduate Certificate In Business Fundamentals

Bachelor Of Science - Bs, Biochemistry And Molecular Biology