Kyle Smith Email & Phone Number

Cambridge, MA, US

• Directed transition of patented microfluidic technologies from Massachusetts General Hospital to MicroMedicine for commercialization as the first employee of the company and inventor of the core technology.
• Contributed to attainment of $38M in funding milestones by building technical team and laboratory, optimizing and locking microfluidic chip designs, and demonstrating technical feasibility for multiple research.
• Advanced corporate strategy, decision-making, and the establishment and maturation of company infrastructure as a member of the Leadership Team.
• Recruited, managed, and mentored a talented team of 12 engineers and scientists comprising three groups: Microfluidics, Systems R&D, and Applications.
• Collaborated with IP counsel to maintain and extend patent portfolio, including filing three utility and four design patents covering important aspects of microfluidic devices, systems, and processes.
• Headed cell therapy manufacturing collaborations with big pharma partners that demonstrated feasibility of the microfluidic technology in achieving performance targets.

Boston, MA, US

• Led and contributed to a wide variety of early-stage translational research projects leveraging microfluidic technologies in research and diagnostic applications, including cancer cell isolation and analysis.
• Invented, optimized, and patented extremely high sensitivity magnetic cell sorting devices (20-fold improvement) for positive and negative selection of circulating tumor cells from blood as part of a $35M joint.
• Directed a collaborative project to design and implement a droplet-based single-cell analysis platform encompassing cell encapsulation, RT-PCR, and multi-color laser interrogation and sorting.
• Invented, optimized, and patented ultra-high throughput microfluidic technologies for high performance sized-based cell sorting (~1 micron resolution) and concentration (up to 400-fold), which were subsequently spun.
• Recruited and managed team of engineers focused on microfluidic device fabrication and evaluation.
• Created algorithmic CAD design generation tools to enable rapid generation and screening of dozens of design variants.

Boston, MA, US

Cambridge, MA, US

• Developed cell- and tissue-level computational models of electroporation and concomitant molecular transport that yielded new insights into the mechanisms of electroporation and became the foundation of all subsequent.
• Explored mechanisms and effects of supra-electroporation, in which sub-microsecond, megavolt-per-meter electric field pulses cause widespread electroporation of plasma and organelle membranes and induce apoptosis.
• Investigated how electroporation may be optimally used in therapies for cancer and other diseases through the use of high throughput in silico experiments.

Durham, North Carolina, US

• Developed novel computational model of electroporation capable of simulating the complex dynamics and interactions of the large electropores required for gene delivery.
• Published research in Physical Review E and Biophysical Journal (first author) and received the Helmholtz Award for the best biomedical engineering research project.

Phd, Biomedical And Electrical Engineering

Sm, Electrical Engineering And Computer Science

Bse, Biomedical Engineering