Kyle Jacoby Email & Phone Number

Princeton, Nj, Us

Leading Kanvas' research and development of microbiome therapies.

Leading a team of scientists and engineers in microbiology, synthetic biology, immuno-oncology, and data science to deliver lead candidates for clinical exploration, and transition programs into early clinical development. Serving as both functional lead and project team lead with primary responsibilities including driving patent filings, IND applications, and investor data packages for cutting edge microbiome cell therapies.

South San Francisco, California, Us

Conceived and led the development of a novel non-viral gene editing method now used to generate PACT’s neoepitope-specific TCR T cells. Led discovery research, process development, and early clinical operations around the gene editing technology. Identified CROs, CMOs, and business partners to support PACT’s research, development, and clinical production, and helped to draft, review, coordinate, and execute subsequent work agreements. Interacted directly with BOD, SAB, FDA, investors, patent examiners, and partners; and provided the clinical team with responses to IRBs and IBCs. Set departmental goals, budgets, and facilities and resource needs.

South San Francisco, California, Us

South San Francisco, California, Us

South San Francisco, California, Us

Seattle, Wa, Us

Responsible for screening, hiring, and training a team of 5 scientists. Lead their work and my own on projects including: 1) improving gene editing using lentivirus, AAV, mRNA transfection, and site specific nucleases (CRISPR/Cas, TALENs, ZFNs, mTALs, and Homing Endonucleases); 2) developing ddPCR-based high-throughput analysis of gene editing (deletions & HR); 3) creating algorithms for selecting optimal targets for genome editing and homing endonuclease re-specification for those sites; and 4) development of a clinically relevant technology to improve mRNA-based gene editing and personalized medicine. For the latter, created white papers, worked directly with legal team to prepare patent applications, and managed external collaborations and sponsored research agreements. Lead the creation of primary tissue culture SOPs. Organized the lab by assembling our strains, constructs, and orders into an electronic database and creating guidelines for its use; by creating best practices for use of a program-wide electronic lab notebook; and by implementing and training our program to use an online project organization tool. Created and maintain a server for data analysis tools for the lab and am the ‘go-to’ person for technical needs.

Seattle, Wa, Us

Seattle, Wa, Us

Developed a new high throughput method for characterizing the specificities of site-specific nucleases (for genome editing in basic sciences, biotechnology, and clinical medicine). Designed the method to tie into our existing flow cytometry-based characterization and directed evolution platform, and created custom software to search for patterns in the resulting next generation sequencing data. Helped to create a human cell and lentiviral-based screening method to report genome editing events capable of being used in high throughput screens.

Seattle, Wa, Us

In the Manoil lab, I used functional screens of protease mutants to identify components involved in Pseudomonas antibiotic resistance.In the Fang lab, I used functional screens to identify components involved in iron metabolism in Salmonella.

Seattle, Wa, Us

Aided professors and headed lectures in Crime Scene Investigation, with an emphasis on its biological (genetic and biostatistical) aspects.

Experience with desktop and server setup, repair, programming, networking, and graphic editing. Volunteered PC fabrication and troubleshooting services to a local elementary and middle school. Continue to learn and implement new technologies in the workplace and at home in my free time.

Santa Barbara, Ca, Us

Studied Contact Dependent Growth Inhibition in E. coli by using functional screens followed by genetic and molecular validation (NSF REU grantee).

Santa Barbara, Ca, Us

Instructor for a campus-run supplement to lecture for undergraduate courses. I generated coursework, taught, and held study sessions for chemistry students.

Boys gymnastics coach

Doctor Of Philosophy (Ph.D.), Molecular And Cellular Biology

Certificate, Molecular Medicine

Bachelor Of Arts (B.A.), Biology, General