Kyle Minch Email & Phone Number

Seattle, Wa, Us

Seattle, Washington, United States

Seattle, Washington, United States

Bellevue, Wa

Innovation, technical, and project lead working on tuberculosis viability monitoring and drug susceptibility testing. Liaison and collaborator with partners at academic institutions, domestic and international non-profits as well as multiple industry partners. Currently leading interdisciplinary project team and regularly communicating project status, risks, and solutions to organization's top managers and stakeholders including top thought and global funding leaders.

Experimental systems biology of Mycobacterium tuberculosis. - Secured Ruth L. Kirchstein training grant fellowship with a competitive renewal for a second year of support. - Coordinated experimental efforts of technicians and undergraduates while developing innovative projects and research directions for the lab: - Developed novel platform for mycobacterial single cell culturing and manipulation on microscope stage. - Collaborated across disciplines to develop computational pipeline to accommodate large-scale imaging data processing requirements - Innovations led to increased throughput and scale of data acquisition, decreasing time from observation to hypothesis testing and generation of results.- Fostered cross-disciplinary collaborations between bench scientists and computational biologists.- Developed and wrote R21 applications on novel approach to live cell imaging of M. tuberculosis (pending review).- Led team generating mutant library of M. tuberculosis strains that critically impacts multi-center, multi-year NIH U-19 projec- Published 2 co-first author papers and 1 additional article during 2.5 year postdoctoral tenure. - Minch, KJ*, Rustad TR*, et al. The DNA binding network of Mycobacterium tuberculosis. Nature Communications. 2015; 9(5829). doi:10.1038/ncomms6829. - Rustad TR*, Minch KJ*, Ma S, et al. Mapping and manipulating the Mycobacterium tuberculosis transcriptome using a transcription factor overexpression-derived regulatory network. Genome Biology 2014;15(11):502. doi:10.1186/s13059-014-0502-3. - Peterson, EJR. Reiss, DJ, Turkarslan, S, Minch, KJ, Rustad TR, Plaisier, CL, Longabaugh, WJR, Sherman DR, Baliga, NS. A high-resolution network model for global gene regulation in Mycobacterium tuberculosis. Nucleic Acids Res. 2015; 42(18): 11291–11303. Published online 2014 September 17. doi: 10.1093/nar/gku777

Seattle, Wa

- National Science Foundation Graduate Research Fellow (2008-2011)- Developed platform to map gene regulatory network of M. tuberculosis. - Published 4 articles during graduate tenure: - Galagan JE, Minch K, Peterson M, et al. The Mycobacterium tuberculosis regulatory network and hypoxia. Nature 2013;499(7457):178-183. doi:10.1038/nature12337. - Rustad TR, Minch KJ, Brabant W, et al. Global analysis of mRNA stability in Mycobacterium tuberculosis. Nucleic Acids Research 2013;41(1):509-517. doi:10.1093/nar/gks1019. - Minch K, Rustad T, Sherman DR. Mycobacterium tuberculosis Growth following Aerobic Expression of the DosR Regulon. Cardona P-J, ed. PLoS ONE 2012;7(4):e35935. doi:10.1371/journal.pone.0035935. - Rustad, T. R., Sherrid, A. M., Minch, K. J. and Sherman, D. R. (2009), Hypoxia: a window into Mycobacterium tuberculosis latency. Cellular Microbiology, 11: 1151–1159. doi: 10.1111/j.1462-5822.2009.01325.x

Oxford, United Kingdom

Worked with multi-disciplinary team of clinician researchers to assess the impact of natural genetic variance on susceptibility to cerebral malaria.

Blantyre, Malawi

Processed blood and tissue samples from primary clinical studies. Assisted in post-mortem sample collection and processing. Assembled database for meta-analysis of clinical indicators of severe malaria progression.Acted as liaison between on-site and visiting scientists & physicians.

Phd, Molecular And Cellular Biology, Experimental Systems Biology & Molecular Biology Of Mycobacterium Tuberculosis

Activities and Societies: National Science Foundation Graduate Research Fellow

Bachelor Of Arts (Ba), Biology, General