Laura Maiorino Email & Phone Number

Cambridge, MA, US

Cambridge, Massachusetts, United States

Cambridge, Massachusetts, United States

Cambridge, Massachusetts, United States

• Research Experience
• Led vaccine translational studies in non-human primates - designing experiments, coordinating plans with vet staff, and data analysis.
• Leveraged research expertise in several collaborative projects, resulting in publications in Science, Science Translational Medicine, Nature BME, PNAS.
• Designed mRNA and self-replicating RNA vaccines for cancer and infectious diseases.Biotech
• Attended Venture Capital University (by Venture Forward and NVCA)
• Worked on pre-IND and IND package preparation for an HIV vaccine clinical trial;

Cambridge, Massachusetts, United States

• Research Experience
• Developed a mouse model for local treatment of lung cancer with intratumoral immunotherapies in Darrell Irvine's lab at the Koch Institute For Integrative Cancer Research at MIT
• Granted a JSMF Postdoctoral Fellowship Award in Understanding Dynamic and Multi-scale SystemsLeadership Experience
• MIT Postdoctoral Association Vice-President, co-led advocacy efforts with the administration
• Managed and hosted a departmental seminar series on Immunology

Cold Spring Harbor, NY, USA

• Research experience:
• Discovered a mechanism of immune-mediated protection from pancreatic cancer metastasis in Dr Mikala Egeblad's lab at the CSHL Cancer Center
• Contributed to the discovery of how Neutrophil Extracellular Traps (NETs) promote breast cancer metastasis
• Collaborated on projects in immuno-oncology and inflammation, cancer biology, drug delivery
• Developed longitudinal imaging technique
• Employed intravital imaging, mouse models of cancer, CRISPR/Cas9 genome editing, histology, bioluminescence imaging, 3D cell culture, flow cytometry and other techniques

Milano, Italia

• Research experience:
• Contributed to the discovery of a function of the COP9 Signalosome, a regulator of E3 ubiquitin ligases, during the oncogene-induced response in controlling oncogene levels and proteins involved in DNA replication.
• Studied the consequences of genetic and pharmacological dysregulation of Cullin-RING E3 ligase complexes in cancer through the study of multiple myeloma and hepatocellular carcinoma.

Milano, Italia

• Research experience:
• Studied the role of the COP9 Signalosome, a regulator of E3 ubiquitin ligases, as a gate keeper during the initiation of liver cancer in a mouse model

Doctor Of Philosophy - Phd, Oncology And Cancer Biology

Thesis project: Identification of cancer-cell intrinsic and host-mediated cellular mechanisms of metastasis through intravital imaging

Master’S Degree In Medical, Molecular And Cellular Biotechnology, 110 /110 Cum Laude And Honorable Mention

Thesis project: Study of ubiquitin ligases in organ homeostasis and cancer initiation using genetically engineered mice and in vitro models.

Bachelor’S Degree In Medical And Pharmaceutical Biotechnology, 110 /110 Cum Laude And Honorable Mention