Head And Director Of Immunology Research
Brentford, Middlesex, Gb
Provide leadership, strategic guidance to Senior Investigators and their staff, focusing on identification,validation and characterization of novel targets in pulmonary and autoimmune diseases, both small molecule compounds and therapeutic proteins. Facilitate compound progression and creation of robust support packages to de-risk entry into development. Participate in key strategic activities, including establishment of therapeutic disease area strategy and portfolio enhancements through in-licensing and key platform collaborative agreements.• Published over 90 peer reviewed manuscripts and 10 patents. Established numerous collaborations to augment scientific knowledge and characterization of novel gene products. • Mentored up to 40 research scientists in the identification and validation of novel gene targets. Established Immunology cell sorting and FACCs analysis platform.• Progressed multiple programs resulting in advancement of 4 novel agents (3 protein, 1 small molecule) as anti-asthma/allergy therapeutics into development.• Strategic influencer of the Inflammation and Tissue Repair Therapeutic area, • Elected president of the Inflammation Research Association (IRA). Chaired the organizing committee for the 2000 Biennal International IRA (4 Day) meeting. Sample Publications and Patents Suppression of monocyte 85 kDa-phospholipase A2 by antisense and effects on endotoxin-induced prostaglandin biosynthesis. Journal of Biology and Chemistry 269:25999-26005, 1994.CBP kinase inhibitors (CSAIDs) reduce CD23 protein expression on activated monocyte cell surface. Journal of Immunology 161:6005-6013, 1998The human polo-like kinase, PLK1, regulates cdc2/cyclinB through phosphorylation and activation of the cdc25C phosphatase. Cellular Signaling, pp 405-411, 2000 Animal Models of Inflammation Second Edition, Birkhauser, Basel ,2006 EP835937, EP835937 - A human homolog of the MYT1 kinase of Xenopus and a cDNA encoding it,