Lara Ibrahim Email & Phone Number

San Diego, California, United States

La Jolla, California

Wiseman and Bollong Labs.• Characterized the functional targets of the stress-activated transcription factors NRF1, NRF2, and NRF3 using RNA sequencing and mass spectrometry-based quantitative proteomics, and contributed these validated target sets to the publicly available Molecular Signatures Database for use in pathways analysis programs such as Gene Set Enrichment Analysis.• Provided a framework to understand the physiological importance of NRF transcription factors by analyzing… Show more Wiseman and Bollong Labs.• Characterized the functional targets of the stress-activated transcription factors NRF1, NRF2, and NRF3 using RNA sequencing and mass spectrometry-based quantitative proteomics, and contributed these validated target sets to the publicly available Molecular Signatures Database for use in pathways analysis programs such as Gene Set Enrichment Analysis.• Provided a framework to understand the physiological importance of NRF transcription factors by analyzing NRF target gene expression levels in human heart, brain, and liver samples using the Genotype-Tissue Expression Project database.• Explored the structure activity relationship of a series of compounds that activate the antioxidant transcription factor NRF2 and inhibit the glycolytic enzyme phosphoglycerate kinase.• Evaluated chemical analogs which efficaciously activate the antioxidant response element with low cytotoxicity in high-throughput luciferase reporter assays.• Identified a new node of communication between the oxidative stress response and the tricarboxylic acid (TCA) cycle by creating a stable NRF2 reporter cell line and conducting a genetic knockdown screen using lentiviral shRNA.• Determined the cellular modifications induced by knockdown of the TCA cycle enzyme and subsequent increase of the reactive metabolite succinic anhydride. Show less

Department Of Molecular And Cellular Biology - Arsuaga Vazquez Lab

Explored the biophysical properties of the mitochondrial DNA of the lethal parasite T. brucei using computer simulations, molecular biology experiments, and electron microscopy.

Department Of Pharmacology - Diaz Lab

Probed the role of palmitoylation of the protein SynDIG4 on its stability, localization, and function, as well as synapse development using various molecular biology techniques such as cloning and immunoblotting.

Tracy, Ca

Instructed students in math and reading, especially young children, students with special needs, and adults learning English.

Doctor Of Philosophy - Phd, Biochemistry

Activities and Societies: Network for Women in Science, Scientific Diversity Association, Scripps Assists, Community Teaching Lab

Bachelor Of Science - Bs, Pharmaceutical Sciences

Activities and Societies: UC Davis Medical Center Volunteer, UC Davis Pre-Health Conference Volunteer, Sigma Xi Scientific Research Honor.

Education record

Activities and Societies: President of Key Club International, California Scholarship Federation, Volunteer Tutor at Give Every Child.