Laura Brion, Ph.D. Email & Phone Number

Argentina

Buenos Aires Province, Argentina

Greater Buenos Aires, Argentina

Buenos Aires Province, Argentina

• Inflammatory Bowel Diseases (IBD) - Crohn´s Disease and Ulcerative Colitis.• Active role in evidence generation and dissemination projects. Co-author of 3 posters at international conferences and 3 manuscripts in development.• Collaborating with market access by supporting payer engagement and value proposition strategies (value dossier, advisory boards). Supported the development of innovative pricing strategies (risk-sharing & cost-effectiveness analysis).• Short-Term Assignment (since September 2022): supporting LATAM affiliates in developing and overseeing RWE projects.

Greater Buenos Aires, Argentina

• Strategic consultancy developing market models, product positioning and adoption strategies, KOLs’ mapping and patient-based models to identify niche markets using prescriptions and claims databases, epidemiological studies and patient registries, both in local and international markets. • Skilled in engaging and maintaining strong relationships with KOLs, HCPs, industry players, national agencies and patient advocacy groups by fostering the unbiased exchange of information and knowledge by being up-to-date on the rare diseases space. • Analyst of clinical trial intelligence and R&D activities within growth hormone, hemophilia, hereditary angioedema and immunoglobulin therapies.

Department Of Medicine, Cardiovascular Research Unit, Stockholm, Sweden

• Project: Role of salt-inducible kinases (SIKs) in the cardiovascular and respiratory systems.• I led and coordinated international experimental and clinical studies on pulmonar fibrosis and hypertension where I was responsible for project planning, scientific publishing, communication and grant writing.• Teaching activities: Instructor and laboratory course organizer in Molecular Medicine (Biomedicine Master's Program, 2015). Students' examination, planning, preparation and execution of 60 hours of teaching per year to master students.

Department Of Medicine, Cardiovascular Research Unit, Stockholm, Sweden

• Principal investigator supported by grants for 3M SEK to investigate cardiovascular diseases.• Project: 1-Effect of chronic high-salt intake on blood pressure and cardiovascular remodeling in relevant mice and cell models and 2- Epithelial-mesenchymal transitions (EMT) in pulmonar and renal epithelium.- Project leader and coordinator of international collaborations within academia and the industry. • Teaching activities: Instructor in Molecular Medicine (Biomedicine Master's Program, 2013-2014). Student's instruction and supervision during laboratory practice.• 3 publications (2 senior authorships).

Novum, Huddinge, Sweden

• Sponsored internship where I combined my scientific background and my growing interest in the pharmaceutical/drug discovery industry. • Project: Effect of inhibition of autophagy on cancer cell migration and characterization of lead compounds from an in-house library.• Responsible for establishing a high-throughput cell-based migration assay for preclinical drug validation within cancer research. Performed assay validation and optimization using cancer cell models.

Feinberg School Of Medicine, Dept. Of Pulmonary And Critical Care, Chicago, Usa

• Laboratory stay in Chicago as part of an international collaborative project in which we identified and characterized a genetically associated biomarker involved in pulmonary fibrosis.• Project: Role of SIK1 and transforming growth factor-beta (TGFb) and sonic hedgehog (Shh) signaling pathways during pulmonary fibrosis. • Studied genetic variants in cohorts of idiopathic pulmonary fibrosis patients (case-control studies) and studied the functional role of these variants in relevant cell and lung injury mice models.

Department Of Biochemistry, School Of Medicine, Buenos Aires, Argentina

- Project: Regulation and functional role of map kinases (MAPKs) and map kinases phosphatases (MKPs) signaling pathways as part of the mechanism of action of ACTH and LH hormones during steroid síntesis.- Teaching activities: Instructor in Biochemistry (Medical Program, 2009). Planning, preparation and execution of 70 hours of teaching per year to 3rd grade medical students. - 5 scientific publications.

Department Of Biochemistry, School Of Medicine, Buenos Aires, Argentina.

- Pre-doctoral project where I studied the molecular events induced by heat shock in steroidogenic cells, particularly the regulation of map kinases (MAPKs) and map kinases phosphatases (MKPs) as signaling molecules. - 2 scientific publications.

Buenos Aires, Argentina

Work at my family footwear retail store as sales and marketing person during summer breaks.

Department Of Genetics And Molecular Physiology, Buenos Aires, Argentina

Participation in a project aimed at identifying functional nuclear localization signals (NLS) within a transcriptional regulator regulated by hypoxia. Studying Drosophila Melanogaster biology.

Doctor Of Philosophy (Phd), Biology/Biological Sciences, General, Outstanding

PhD at the University of Buenos Aires, Department of Biochemistry, Medical School, Buenos Aires, Argentina. Thesis title: Hormonal.

Licentiate Degree, Biology/Biological Sciences, General, 10

Licenciate in Biological Sciences at the University of Buenos Aires, Buenos Aires, Argentina. Diploma student (equivalent to Master.

Introducción A Las Evaluaciones De Tecnologías Sanitarias Y Evaluaciones Económicas

Posgrado, Formación De Medical Science Liaisons (Msls) & Medical Advisors (Mas)

Diplomatura, Marketing Farmaceutico

Pharmaceutical Bioinformatics Course, Pharmaceutics And Drug Design

Monitor De Ensayos Clinicos, Curso De Postgrado

Leadership And Laboratory Management Course, Project Management