Lauren Rost, Phd Email and Phone Number

• Chair the Enterprise AI Translation Advisory Board (21 members) empowering internal Mayo Clinic stakeholders with pivotal AI consulting and efficient connections to ignite translation of AI models into the clinical workflow • Organize and coordinate clinical shadowing, user interviews, implementation science research, AI ethics, and model documentation research to facilitate timely analysis and high-throughput of projects through the Board’s advisory process• Collaborate with hospital leadership, data scientists, software developers, knowledge engineers, etc. to deliver health technology products that enhance patient care through improved access to services and health metrics

• Develop and implement artificial intelligence models into Mayo Clinic departments’ clinical workflows• Transform biomedical data into informatics solutions that solve challenges in clinical practice or business • Collaborate with subject matter experts, data scientists, software developers, and knowledge engineers• Use FHIR technology to transform data into informatics solutions for ameliorating clinical practice or business

• Created predictive models for major depressive disorder patients using electronic health record and pharmacogenomics (PGx) data to inform antidepressant prescribing and improve patient outcomes• Established a reproducible data processing and machine learning pipeline to be re-implemented as a cohort of 150,000 patients are enrolled in the PGx study panel containing 4,627 markers within 1,191 genes

• Conducted a large-scale analysis of international antibiotic prescription guidelines to understand the variation in hospital-specific and country-wide approaches to antibiotic prescribing for common bacterial infections• Collaborated with the antibiotic stewardship team at UPMC to enhance stewardship interventions, decrease inappropriate antibiotic use, and mitigate antibiotic resistance through the use of electronic health record data • Mined electronic health records for rates of antibiotic resistance and prescribing patterns at UPMC over time

• Conducted a microRNA (miRNA) expression quantitative trait loci (eQTL) analysis from pancreatic tumor samples in order to detect significant relationships between germline variants and levels of microRNA expression• Investigating functional validation for in silico significant miRNA from miQTL study, through determining whether predicted interactions with messenger RNA are taking place and playing a role in cancer biology• Assisting in the establishment, employment, and computational analysis of a massively parallel reporter assay (MPRA) that screens SNPs and Indels for allele-specific expression differences in pancreatic and kidney cancer cell lines• Generated and maintained pancreatic cancer cell lines that stably express TERT gene variants in order to determine the effect of mutant TERT on telomerase expression and telomere length over the span of one year• Conducting functional experiments (3C, IP Western Blot, Luciferase Reporter Gene Assay, etc.) in order to better understand the mechanisms by which ZNF148 regulates TERT and CLPTM1L

• Tested and gathered data of second and third order local streams for a series of stream characteristics• Used a stream determinant protocol in order to classify streams as perennial, intermittent, or ephemeral in order for the streams to be appropriately classified and protected by the Clean Water Act • Analyzed the effectiveness of a currently published stream-grading protocol for a region with different stream features in order to create a more applicable stream-determining protocol for St. Mary’s County

• Learned about computational methods for biological data sets and extended knowledge in genomics• Sought to assist Dr. Emerson with his research on mosquito genomics (Anopheles darlingi) and their relation to Plasmodium infection • Attended weekly lab meetings concerning the progress of the lab and recent published literature in the field

• Taught and facilitated a laboratory on seed and embryo development where students exposed seeds to agar containing gibberellic acid • Answered students’ questions concerning Principles of Biology II material for example plant and animal physiology, characteristics of clades and particular organisms, and hormones• Held review sessions for lab practicals and graded lab practicals • Set up the laboratory activities weekly with the teaching assistant team

• Observed patient visits and interacted with patients, being mindful of confidentiality, respect, and professionalism• Learned about obstetrics and gynecology through Dr. Kalpana Helmbrecht’s mentoring and textbooks

• Communicated with coaches of opposing tennis teams to organize and schedule matches and tournaments• Facilitated the ordering and distribution of gear for a team of 200 individuals• Corresponded with parents of the team in order to maximize parental involvement and awareness• Generated an overall positive and energetic spirit for the team, and tennis in general