Laurie Lambot, Ph.D. Email & Phone Number

Boulder, CO, US

• At Modendo, we develop cutting-edge ultrathin endomicroscopes designed for high-resolution optical imaging deep within the brain. I guide the translation of these innovative tools to empower the neuroscience community.
• Engineering biocompatible brain implants using Computer-Aided Design (CAD), with expertise in bioprinting and biomaterials.
• Knowledge of global regulatory guidelines such as FDA, and other health agencies.
• Engineering devices for awake behaving neuronal recording, supporting neuroscientists in advancing their research capabilities.
• Developing experimental strategies in-house and fostering international collaborations for continuous advancements in neurotechnology.
• Leveraging data science methodologies to enhance the efficacy of brain implants and recording devices.

Chicago, IL, US

• Exploring beyond traditional synaptic plasticity, my research at the University of Chicago focused on the critical role of inherent neuronal changes in learning and memory. I led a project to develop innovative imaging.
• Directed a team of undergraduate researchers, setting research objectives, tracking progress, and providing mentorship and feedback. This nurtured an environment that encouraged growth, innovation, and research.
• Managed critical laboratory operations, including the development of new surgical protocols and ensuring compliance with IACUC and biosafety standards.
• Oversaw the management of viral and mouse transgenic strategies for genetic studies, enhancing the capability for in-depth genetic research.Innovation and Research Excellence:
• Independently applied my scientific expertise to a comprehensive assessment of neural activity, utilizing mouse lines with specific deficits in plasticity pathways. This was complemented by a mix of advanced imaging.
• Engaged in the scientific community by editing and reviewing manuscripts, grants, and presentations, promoting the dissemination of quality research findings.Keywords: somatosensory cortex, chronic cranial window.

Chicago, IL, US

• Immersed myself in the complexities of synaptic circuit organization within the neocortex, emphasizing the interplay of synaptic and circuit-level dynamics. My research included the detailed investigation of a cortical.
• Implemented highly efficient, less invasive spinal cord surgery.
• Designed, cloned and tested plasmids for custom AAV production.
• Implemented strategy to express optogenetic tools in subpopulation of cortical projecting neurons via intersectional AAV injections.
• Characterized neuronal connectivity/morphology via confocal/two photon microscopy, clarity tissue clearing technique, and 3D reconstruction (Imaris).
• Validated drugs by local application during patch clamp recording on acute brain slices.

• Spearheaded electrophysiology and imaging in a collaborative neurophysiology research project with Janssen R&D (Stellar collaborative project) to develop a molecular toolbox to study human neuronal function and.
• Led and presented in a collaborative project with Janssen R&D, sharing findings on human neuronal function with European neuroscience leaders, emphasizing cross-team collaboration.
• Mentored a graduate student in patch-clamp and imaging techniques, contributing to the training of future neuroscientists.
• Developed protocols to isolate and sort neurons from iPSCs/ESCs transplanted into mice, supporting advanced cell analysis.
• Monitored synaptic formation and neuronal activity in transplanted human neurons, using electrophysiological recordings and imaging.Keywords: FACS, electrophysiology, confocal imaging, human IPSC.

Ixelles, Bruxelles, BE

• Directed a comprehensive range of research projects aimed at understanding the physiological and pathological mechanisms of the striatum within the basal ganglia, focusing particularly on how these processes influence.
• Conducted comprehensive behavioral, electrophysiological, and imaging analyses, employing tools such as confocal imaging and 3D neuron morphology reconstruction to explore neuronal dynamics.
• Managed a mouse colony, overseeing its organization, breeding, and genotyping, to ensure the availability of appropriate models for research.
• Played a key role in mentoring and supervising undergraduate and graduate students, enriching their research skills and academic development.
• Secured significant research funding, including a €150,000 FRIA grant and a €5,000 grant from the Fondation David et Alice Van Buren, in recognition of the project's potential and excellence.
• Effectively communicated our research findings through presentations at academic conferences and publications.Keywords: NMDA receptor, goal-directed behavior, spine morphology, striatopallidal neuron, striatum.

Paris, Île-de-France, FR

• Investigate and researched protocols to induce long-term protentiation of striatal medium spiny neurons.

• Taught biology and chemistry in several classes ranging from general to specialized education.
• Developed contextually relevant curriculum to match core science standards building on students core interests.

Louvain-la-Neuve, Brabant Wallon, BE

• Worked with four labs. During the lab rotations, I engaged with peers and senior faculty in cellular and molecular biology work.
• Project: Strucural and functional study of PEX1 and PEX6, proteins involved in glycosoma biogenesis in Trypanosoma brucei.Advisor: Fred OpperdoesResearch unit of tropical disease (TROP) – Christian de Duve institute.
• Project: Study of the AMPK/insulin effect on the AS160 phosphorylation and glucose uptake.Advisor: Luc BertrandPole of cardiovascular research (CARD) – Institute of experimental and clinical Research
• Project: Study of the effects of interleukin 9 at cellular and molecular level.Advisor: Jean-Christophe RenaudExperimental medicine unit (MEXP) – Ludwig Institute for Cancer Research
• Project: Study of the Src influence on cellular morphology, proliferation and guidance.Advisor: Pierre Courtoy Cell Biology Unit (CELL) – Christian de Duve institute (DDUV)Keywords: Molecular biology, cellular biology.

Education record

Doctor Of Philosophy - Phd, Neuroscience

Master'S Degree, Biomedical Sciences, General

Bachelor'S Degree, Biomedical Sciences, General