Layton Smith Email and Phone Number
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With over 15 years of experience driving Target-to-Clinic drug discovery projects, I have built and led high-performance discovery teams, establishing the cross-functional collaboration necessary to advance discovery pipelines through IND. My journey has taken me from startups to major pharmaceutical players, where I've fostered a culture of trust, respect, and results.At Fate Therapeutics, I served as Vice President of Preclinical Pharmacology & Toxicology. In this role, I oversaw all in vivo studies essential for advancing Fate’s pipeline of iPSC-derived, genome-edited cellular therapies. A highlight was coordinating research efforts between Fate and Janssen Pharmaceutical, delivering two clinical development candidates. I managed both in-house and outsourced studies, delivering over 200 in vivo studies annually to support six concurrent discovery and late preclinical development programs.Before Fate, I was Executive Director and Head of Biology & Pharmacology at Sanford Burnham Prebys Medical Discovery Institute. There, I set the vision and drove the execution of biology and pharmacology operations, advancing high-risk, high-reward drug discovery projects. Leading a team of 25 with a multimillion-dollar budget, I expanded therapeutic area capabilities and secured $5 million in new funding to support over ten new research projects. Cultivating a relationship with an international chemical vendor, I established a new revenue stream and enhanced SBP's reputation for collaboration.My tenure at Sanford Burnham began as Director and Site Head of Drug Discovery, where I led over 30 FTEs in advancing a deep portfolio of drug discovery initiatives. Balancing resources between bi-coastal sites, I positioned operations toward long-term sustainability and instilled an “innovation first” mindset. This resulted in a first-in-class pipeline based on ownership, empowerment, and accountability. Securing a multiyear partnership with a global pharma company to innovate novel heart failure treatments was a key accomplishment.My academic background includes a Ph.D. in Pharmacology and an M.S. in Clinical Investigation from Vanderbilt University, as well as a B.S. in Cellular and Molecular Biology from Tulane University. Throughout my career, I have partnered with and fostered a culture of trust, respect, and results among team members at all levels, consistently driving drug discovery projects to successful outcomes and advancing the pharmaceutical industry.
Zoe Biosciences
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Vice President, Drug DiscoveryZoe Biosciences Mar 2024 - PresentJoined founders of this start-up, pre-seed company focused on developing innovative therapies for age-related diseases and extending the human healthspan. I set the strategy to accelerate Zoe's pipeline of assets from late discovery into the clinic. I'm also supporting the CEO and CSO in their efforts to secure additional funding to take our lead asset ZB-201 from development candidate into Phase 1 FIH studies. -
Senior Advisor | Principal | FounderCalusa Chemical Biology Consultants, Llc Oct 2018 - PresentAs an independent consultant, I provide subject matter expertise (SME) in all aspects of early drug discovery, including assay development, HTS, ADME/DMPK, Target ID, Target assessment and derisking, molecular pharmacology, in vivo efficacy, and nonclinical development, IND.
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Vice President, Preclinical DevelopmentAbilita Therapeutics, Inc. Jan 2024 - Mar 2024San Diego, Ca, UsRecruited by CSO and reporting to CEO, I spearheaded new initiatives in drug discovery at this seed stage, start-up company leveraging proprietary target stabilizing EMP technology. During this short contract task, my key contribution was to establish the first small molecule discovery program at Abilita. I designed and implemented a strategic plan to apply DNA-Encoded Library and virtual screening appraoches to identify novel GPR75 antagonists for the treatment of obesity & the metabolic syndrome. -
Vice President, Preclinical Pharmacology & ToxicologyFate Therapeutics Inc Jan 2022 - Mar 2023San Diego, California, UsI was recruited to oversee all in vivo studies essential for advancing Fate’s pipeline of iPSC-derived, genome-edited iNK and iT cellular therapies. I determined the preclinical scientific strategy to propel therapies for oncology and emerging new indications. Leading a large, multifunctional team, I provided daily results-oriented leadership, focusing on novel animal model development and implementation, in vivo xenograft studies, biodistribution and persistence (PK) studies, toxicology studies, and post-IND inquiries. Reporting directly to the Chief R&D Officer, I played a pivotal role in shaping our research direction.One of my key achievements was strengthening our drug discovery operational framework. I identified and developed new tools to advance the pipeline, ensuring our team was aligned with strategic goals. I also curated non-clinical data packages and collaborated closely with Regulatory Affairs, resulting in the successful submission of two INDs to the FDA.I coordinated the integration of research efforts between Fate and Janssen Pharmaceutical, which led to the delivery of two clinical development candidates. My management extended to both in-house teams and outsourced (CRO) studies, facilitating the completion of over 200 in vivo studies annually. These studies supported six concurrent discovery and late preclinical development programs.Additionally, I ensured that our corporate research was reported and published at national scientific conferences and communicated effectively to investors, collaborators, and other stakeholders. This comprehensive approach not only advanced our therapeutic pipeline but also reinforced our position as a leader in innovative cellular therapies. -
Executive Director, Head Of Biology And PharmacologySanford Burnham Prebys Medical Discovery Institute Aug 2019 - Jun 2022La Jolla, Ca, UsI was promoted to set the vision and drive the execution of all aspects of biology and pharmacology operations at SBP, overseeing 25 FTEs and managing an annual budget of approximately $9M. My role was pivotal in propelling SBP's pipeline of high-risk, high-reward small-molecule and peptide drug discovery projects. As a subject matter expert in molecular and basic pharmacology, I supported eight lead optimization and pre-clinical/non-clinical development programs.Notably, I strategically expanded our therapeutic area capabilities to support new efforts in neuroinflammation and mental health, which secured $5 million in new funding and supported over ten new research projects. I also cultivated a relationship with an international chemical vendor to distribute SBP tool compounds worldwide, establishing a previously untapped source of revenue and enhancing SBP's reputation for collaboration.In a joint effort with the Executive Director of Medicinal Chemistry, I co-led the initiative to replenish and expand our compound library with 100,000 new structures. This project leveraged open-source datasets and state-of-the-art cheminformatics and machine learning tools, significantly enhancing our research capabilities.As an NIH-funded Principal Investigator, I led research efforts into the discovery and development of compounds as novel treatments for neurological diseases (GPR52), cardiovascular and metabolic diseases (CX3CR1, GPR22), and oncology (ACK1). This research generated over $3 million in annual revenue through three RO1 grants, further solidifying our position in these critical areas of drug discovery.Through these efforts, I was able to advance our scientific objectives while fostering a culture of innovation and collaboration, driving SBP’s mission to develop groundbreaking therapies. My leadership ensured that we not only met but exceeded our strategic goals, positioning SBP as a leader in the field. -
Director, Drug DiscoverySanford Burnham Prebys Medical Discovery Institute Apr 2010 - Aug 2019La Jolla, Ca, UsI was promoted to drive scientific excellence and bring a strategic development focus to a team of over 30 FTEs, advancing a deep portfolio of more than 50 drug discovery initiatives, ranging from concept to pre-clinical in vivo efficacy studies. I balanced resources between bi-coastal sites in collaboration with the Director of Medicinal Chemistry and the Senior Vice President of Drug Discovery & Development. Additionally, I served on the Joint Steering Committee for a collaboration with Daiichi-Sankyo.I positioned our operations for long-term sustainability, fostering an “innovation first” mindset that resulted in a first-in-class pipeline characterized by ownership, empowerment, and accountability. This cultural shift was instrumental in driving our scientific endeavors forward.One of my notable achievements was securing a multiyear partnership with a global pharmaceutical company to innovate novel heart failure treatments using small molecule therapeutics targeting APJ, RXFP1, and ASK1. This collaboration underscored our commitment to pioneering therapeutic solutions and demonstrated our capability to attract and maintain strategic partnerships.My leadership ensured that we advanced our scientific objectives while maintaining a focus on innovation and strategic development, ultimately positioning us as leaders in the drug discovery field. -
Assistant Professor, Diabetes And Obesity Research CenterSanford Burnham Prebys Medical Discovery Institute Mar 2009 - Aug 2019La Jolla, Ca, UsI led groundbreaking research as an NIH-funded Principal Investigator, exploring the molecular pharmacology of the apelin system and its physiological and pathological roles, including its interaction with the renin-angiotensin system.I forged a strategic partnership with a global pharmaceutical company to develop novel heart failure treatments using small molecule therapeutics targeting the apelin receptor.My work has been widely recognized, with over 50 peer-reviewed papers published, showcasing my contributions to the field and commitment to advancing scientific knowledge and therapeutic innovation. -
Director, PharmacologySanford Burnham Prebys Medical Discovery Institute Oct 2007 - Oct 2010La Jolla, Ca, UsI first joined the organization as an early member of the Pharmacology team. I established a new Pharmacology group and built out high-throughput ADME, DMPK and bioanalytical capabilities, expertly translating pharma Best Practices within the context of academic drug discovery
Layton Smith Skills
Layton Smith Education Details
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Vanderbilt University School Of MedicineClinical Investigation -
Vanderbilt UniversityPharmacology -
Tulane UniversityCellular And Molecular Biology
Frequently Asked Questions about Layton Smith
What company does Layton Smith work for?
Layton Smith works for Zoe Biosciences
What is Layton Smith's role at the current company?
Layton Smith's current role is Senior Executive • Biomedical Research Scientist: Target-to-Clinic Drug Discovery • Pharmacology • Strategic Leadership ➢ I set and steer the research strategy to drive new and alternative therapies to patients worldwide.
What is Layton Smith's email address?
Layton Smith's email address is lh****@****ery.org
What is Layton Smith's direct phone number?
Layton Smith's direct phone number is +140725*****
What schools did Layton Smith attend?
Layton Smith attended Vanderbilt University School Of Medicine, Vanderbilt University, Tulane University.
What skills is Layton Smith known for?
Layton Smith has skills like Drug Discovery, Pharmacology, Assay Development, High Throughput Screening, Pharmacokinetics, In Vivo, Cross Functional Team Leadership, Program Development, Strategic Planning, Business Planning, Start Ups, Portfolio Management.
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