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I believe that innovation is sparked at intersections and that impactful solutions will come from the broad-view now, as well as than the long-view later.Things that make me excited: practical invention for the most immediate benefit, breaking technological monopolies, small groups going great things, progress. I have therefore devoted my career to working in teams that are doing hard science and heavy lifts. AI is a hot topic - sure, the computers can crunch data, find hits, spot trends, but can they design new drugs faster and cheaper than ever before? Will we have an "Alpha-fold" moment for total, multi parameter drug design going beyond hit generation? Whilst AI can be open source, the limits lie in accessible, quality data, and here, many gates are closed. Phare Bio is an antibiotic developer combining drug discovery AI developed by Prof. Jim Collins (MIT) with a non-profit business model to combat the unseen pandemic of AMR; accountable for the deaths of > 1.1M people a year.RNA has a lot of offer, but a lot to prove; the companies in the space I work/worked with recently are: Sensible Bio - working on an alternative to the omni-utilized IVT reaction.Orion Therapeutics - offering one of the only truly differentiated lipid technologies for delivery. VxBiosciences - harnessing RNA entirely novel use-cases.
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Vp Of SciencePhare Bio Sep 2024 - Present- Working with scientists at the Collins lab, MIT to build AI for antibiotic drug discovery - Fundraising and technical lead on grants - Database building of ML training - Overseeing a translational drug pipeline to preclinical studies - TPP and commercial analysis- IP strategy -
Director Of R&D And Scientific StrategyPhare Bio Oct 2021 - Sep 2024• Directing R&D programs through a global network of CROs, planning antibiotic drug development for multiple TPPs and RoAs.• Landscape mapping of current antibiotic unmet needs and strategies for overcoming poor market incentives using a non-profit business model and industry partnerships.• Liaising with clinicians to define unmet needs and patient population specific TPPs.
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ConsultantSensible Biotechnologies Sep 2024 - Present -
Head Of ScienceSensible Biotechnologies May 2023 - Sep 2024Head of Science across two labs directing R&D efforts for the cell-based production of therapeutic mRNA. - Managing > 18 scientists. - IP and preclinical strategy - inventor on 2 patents - Lab building, hiring and budgeting.- Fund raising (private and public)
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ConsultantOrion Therapeutics, Inc. Apr 2023 - PresentConsulting on scientific and fund raising strategies for RNA drug delivery -
Head Of Drug Delivery TechnologyStealth Mode Biotech Jan 2023 - Apr 2023Sevenoaks, GbPlanning IP and R&D strategy for novel nucleic acid delivery technologies -
DirectorVxbiosciences Feb 2021 - Nov 2022• Directing RNA nasal formulation development, managing the analytical and production strategy to GMP, including RNA drug substance production scale up to GMP. • Authoring SOPs and interacting with government funding agencies and academic partners.
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Senior ScientistPfizer Jun 2018 - Feb 2021New York, New York, UsI joined the Novel Delivery Technologies Group, part of Pharmaceutical Research and Development, Pfizer. • Lab-lead for projects including: the COVID vaccine, conjugated oligonucleotides and nanoparticle-protein conjugates.• Chemical expertise with lipids, RNA, nanoparticles, proteins, conjugation methods, multiple analytical techniques and stability strategies.• Internal due diligence experience • Pfizer 'Business of Science' certification -
Visiting Postdoctoral ResearcherRadboudumc Oct 2017 - Dec 2017Nijmegen, NlWorking on immunogenic hydrogel technologies. Techniques:-The chemical modification of polysaccharides -Biocognation chemistry with antibodies and protein complexes -Confocal microscopy -Human T cell culture -Immunostaining, flow cytometry and ELISA -
Postdoctoral Research FellowThe University Of Auckland May 2017 - Sep 2017Auckland, NzI worked in collaboration with the Dunbar and Brimble labs on vaccine constructs for human ex-vivo T cell priming.Techniques:-Ex-vivo human DC culture conditions optimisation-DC maturation and co-stimulation -Human naive T cell culturing and priming -Antigen uptake and presentation -
Postdoctoral ResearcherUniversity Of Oxford Oct 2015 - Dec 2016Oxford, Oxfordshire, GbI undertook a one year post-doctoral contract, working in collaboration between the Ben Davis and Quentin Sattentau groups at Oxford University. I worked on the synthesis of protein-reactive carbohydrates and the modification of whole protein vaccine candidates. Techniques:-Organic synthesis-ELISA-Flow cytometry-T cell assays-Luminex assay-Mouse vaccination studies -
D.Phil StudentUniversity Of Oxford Oct 2011 - Oct 2015Oxford, Oxfordshire, GbI completed my D.Phil in Chemical Biology under the supervision of Prof. Ben Davis, my thesis focused on chemical modification of adenoviral vectors for DNA vaccination and immune evasion. My paper ‘Synthetic glyco-viruses for targeted DNA therapy and immune evasion’ is currently in submission. Working at the interface of chemistry and immunology has allowed me to both synthesise vaccines and investigate their therapeutic potential in vitro and in vivo.Techniques:-The total synthesis of trisaccharides -Protein modification -Virus production-In vitro cell essays and immunological studies-In vivo essays -Proteomics-Primary cell culture -Mouse models -Bioluminescence imaging
Leanne Minall Skills
Leanne Minall Education Details
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University Of OxfordChemical Biology -
Worcester Polytechnic InstituteFundamentals Of Biomanufacturing
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University Of BristolChemistry
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Uc San Diego Extended StudiesQuality Assurance And Control
Frequently Asked Questions about Leanne Minall
What company does Leanne Minall work for?
Leanne Minall works for Phare Bio
What is Leanne Minall's role at the current company?
Leanne Minall's current role is VP of Science.
What is Leanne Minall's email address?
Leanne Minall's email address is lo****@****e.co.uk
What is Leanne Minall's direct phone number?
Leanne Minall's direct phone number is +4479517*****
What schools did Leanne Minall attend?
Leanne Minall attended University Of Oxford, Worcester Polytechnic Institute, University Of Bristol, Uc San Diego Extended Studies.
What are some of Leanne Minall's interests?
Leanne Minall has interest in Science And Technology.
What skills is Leanne Minall known for?
Leanne Minall has skills like Biochemistry, Immunology, Chemical Biology, Protein Expression, Organic Synthesis, Virology, Cell Culture, Animal Studies, Protein Chemistry, Proteomics, Organic Chemistry, Teaching.
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