Created a platform for high through put screen the libraries in mammalian cells.Applied this platform to identified several riboswitches that are hundreds fold better than previous reports.Based these riboswitches, constructed gene regulatory cassette that could be used for clinical trial.Now testing several candidate genes expression using AAV system.

Developed and optimized a new technique in situ fucosylation, for adding fucose on cell surface in vitro or in vivo.Developed and optimized the technique for monitoring the fucosylation level in vivo. Based on this technique, published an article for the dynamics of fucosylation during early zebrafish development. Found and published the relation of fucosylation and Wnt activity. Found the cellular mechanism of how fucose manipulating the Wnt activity.Applied TALEN and CRISPR-cas9 system for making specific gene mutations in zebrafish.Tested the relation between fucosylation and tumor cell line malignancy.Tested the function of fucosylation in T cell differentiation and maintenance. Developed and tested several new drugs for Parkinson's disease.Tested and screened drug libraries in zebrafish model system.