Lei Wang, M.D. Email and Phone Number
As the director of CAR-T-cell development at MiGenTra GmbH, I lead a team of scientists and engineers to develop innovative and personalized cellular therapies for cancer patients. I have over 10 years of experience in the field of cellular immunotherapy, with a strong background in immunology, medicine, R&D, GMP manufacturing, and data science. I am certified in GMP and ICH-GCP, and I focus on developing advanced therapy medicinal products (ATMPs) that meet the highest quality and regulatory standards. I have designed and implemented analytical methods, quality control systems, and ATMP applications for various cellular products, and I have successfully obtained the ATMP classification and the permission for phase II clinical trial from the European Medicines Agency (EMA). I have also contributed to 42 peer-reviewed publications with a total impact factor of 333, and received 4 awards for my research excellence. I am passionate about translating basic science to GMP and bringing novel immunotherapies to the market and to the patients.
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Director Of Car-T-Cell Therapy DevelopmentMigentra Gmbh Feb 2023 - PresentBerlin, Germany; Cairo, Egypt; Heidelberg, Germany
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Head Of Cell Therapy DevelopmentTolerogenixx Gmbh Jan 2022 - Jan 2023Heidelberg, Baden-Württemberg, Germany• Driving a comprehensive characterization of a cellular product by advanced high-throughput technologies to fulfill authority requirements, apply new patents and provide evidence for treating autoimmune disease• Established, modified and overseed the quality control system including functional cellular potency assays, enabling to meet the large-scale production• Designed analytical method validation and supervised cross-functional teams to conduct, document, analyze and report the validation• Drafted the complete ATMP application and persuaded EMA’s CAT, successfully obtaining the ATMP classification• Prepared and supported the application of phase II clinical trial, receiving the permission by the national authority -
Senior Project ManagerTolerogenixx Gmbh Jan 2020 - Dec 2021Heidelberg Area, Germany• Planed and executed logistics studies, demonstrating the feasibility of the centralized manufacturing hub model to reduce cost and boost revenue for the business investments• Devised and optimized a new manufacturing process step-by-step, broadening the product indication from living to deceased organ transplantation• Improved and simplified the manufacturing process for saving time and man power• Answered the authorities’ questions (EMA, FDA and PEI) from the scientific and manufacturing aspects, and updated the IB and IMPD accordingly• Connected a potential investment partner and organized several meetings
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Wissenschaftlicher MitarbeiterTolerogenixx Gmbh Feb 2017 - Dec 2019Heidelberg Area, Germany• Developed and performed functional cellular assays, delivering the results of potency assay to complete phase I clinical trial• Created and maintained SOPs, leading to consistent performance and easy transition• Manufactured the cellular product in GMP lab
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Senior Research And Development ScientistUniversitätsklinikum Heidelberg (Ukhd) Nov 2016 - Jan 2023Heidelberg Area, Germany• Leading team of 3 doctoral fellows working in CAR-T cells to optimize CAR vector and to develop novel combinational strategies to enhance clinical efficacy with less side effects and received 2 awards in EBMT• Supervising 1 doctoral fellow to establish strategic pipelines, resulting in identification of 6 biological signatures of SR-aGvHD by immune profiling and machine learning-based advanced analysis• (Co-) authored 40 peer-reviewed publications with a total impact factor of 324 in the field of cellular immunotherapy and guided 2 students to successfully receive doctoral degree with magna cum laude and received 2 awards in ASH and DGHO• Designed and implemented quality controls and stability study to fulfill authority requirements, supporting our team to obtain authority permission and conduct Germany’s first academic phase I clinical trial of CAR-T cells• Participated and supported 3 phase I clinical trials through immunomonitoring, managing and analyzing data -
Resident DoctorZhongda Hospital Southeast University Jun 2010 - Jun 2012中国 江苏 南京• Evaluated patients’ symptoms initially, followed by diagnosing, documenting, treating and managing over 100 patients• Managed difficult conversations to smoothly deliver unfortunate news to patients and relatives• Educated senior medical students by giving lectures and supervised over 20 interns in the clinical practice -
TeacherSchool Of Medicine At Southeast University Oct 2010 - Jan 2011中国 江苏 南京teach Clinical Diagnostics
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Director Of Academic AffairsGraduate Students Union, Southeast Universit Oct 2009 - Jul 2010中国 江苏 南京
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InternZhongda Hospital Southeast University Jun 2008 - Jun 2009中国 江苏 南京Intern, All Clinical Depts.
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InternCancer Center Of Xinjiang Medical University Jul 2005 - Aug 2005中国 新疆 乌鲁木齐Intern, Dept. of Orthopedics
Lei Wang, M.D. Education Details
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Clinical And Industrial Drug Development -
Cellular Immunotherapy -
Haematology -
Clinical Medicine
Frequently Asked Questions about Lei Wang, M.D.
What company does Lei Wang, M.D. work for?
Lei Wang, M.D. works for Migentra Gmbh
What is Lei Wang, M.D.'s role at the current company?
Lei Wang, M.D.'s current role is Director @ MiGenTra | Cellular Immunotherapy, MD.
What schools did Lei Wang, M.D. attend?
Lei Wang, M.D. attended Harvard Medical School, Ruprecht-Karls-Universität Heidelberg, Southeast University, Southeast University.
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