Li Gan Email and Phone Number
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• Over fifteen years of drug discovery research experience in academia and industry with strong scientific background on neurobiology, pharmacology, human neurodegenerative, neuromuscular, muscular and rare diseases • Familiar with multiple therapeutic modalities including RNA splicing modulation with antisense oligonucleotides and small molecules, gene therapy and protein degradation by lysosome-autophagy pathway • Experience with all stages of drug discovery from target identification to preclinical IND filing• Cross functional collaboration, broad experimental skills and strong problem-solving capability, detail oriented and well-adapted in the fast-paced pharmaceutical industry• Team leads with extensive CRO management experience
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ConsultantGenabio Diagnostics Jan 2024 - PresentBedford, Massachusetts, Us
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Senior Principal ScientistSkyhawk Therapeutics May 2022 - Mar 2023Waltham, Massachusetts, Us -
Principal ScientistSkyhawk Therapeutics Aug 2019 - May 2022Waltham, Massachusetts, Us• Scientific leader for neurological diseases through target identification, approach validation, HTS, hit to lead, lead optimization, preclinical animal studies, candidate selection and biomarker exploration • Leveraged internal and external resources, and designed fit-for-purpose assays to profile small molecule pharmacology and mechanism of actions• Participated in animal study design and developed/transferred ex vivo assays for pharmacodynamic readout• Oversight of research activities in domestic and international CROs at different drug discovery stages. Created corresponding research plans to facilitate the initiation and progress• Project management: streamlined and coordinated/prioritized the research activities from different groups to ensure the timely deliverables • Set up and managed weekly screening biology assays for SAR. Quality control of the screening data. Data interpretation and presenting
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Scientist IiSarepta Therapeutics Oct 2016 - Aug 2019Cambridge, Ma, Us -
ScientistSarepta Therapeutics Sep 2014 - Sep 2016Cambridge, Ma, Us• Built and led a dedicated team working on the CNS delivery of antisense oligonucleotide PMO-based chemistries and explored new disease indications: designed PK/PD animal studies to compare the chemistry properties, dose range and tolerability, biodistribution, and cellular location• Leading scientist for spinal muscular atrophy project: micro-walking to identify lead candidates; compared different chemistries in vitro and in vivo • Leading scientist for other diseases projects including Huntington disease and brain dystrophin• Generated the preclinical pharmacodynamic data package including mouse and NHP studies for PPMO platform for DMD• Participated in the preparation of the investigation of new drug filing document and discussion of clinical trial design • Prepared the manuscript for publication• Clinical biomarker assay transfer and optimization • Leading scientist for combinational therapy of Adeno-associated virus (AAV) gene therapy and RNA technology• Set up a new biology laboratory and developed assays for research activities
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Assistant ScientistUniversity Of Wisconsin-Madison 2012 - 2014Madison, Wi, Us -
Postdoctoral Research AssociateUniversity Of Wisconsin-Madison Jul 2007 - Jun 2012Madison, Wi, Us• Explored molecular mechanisms of Parkinson’s disease (PD) with cell culture system, sporadic (MPTP) and familiar PD mouse models; Investigated the neuroprotective roles of anti-oxidative stress pathway Nrf2-ARE in PD from in vitro and in vivo, leading to a pioneer discovery of astrocytic Nrf2 eliminating misfolded α-synuclein in neurons through improved autophagy function.• Explored the effect of astrocytic Nrf2 on AAV mediated α-synuclein (WT and A53T) expression in substantial nigra of mice• Gene therapy: injected Adeno vrius-Nrf2 into MPTP-PD mouse model to explore neuroprotection of overexpressing Nrf2• Examined potential small molecule Nrf2 activators in vitro and in vivo
Li Gan Skills
Li Gan Education Details
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Und School Of Medicine & Health SciencesNeurobiology -
Ocean University Of ChinaNeurobiology
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Ocean University Of ChinaPharmacology
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West China Medical University (Sichuan University)Pharmaceutical Sciences
Frequently Asked Questions about Li Gan
What company does Li Gan work for?
Li Gan works for Genabio Diagnostics
What is Li Gan's role at the current company?
Li Gan's current role is Neurobiology | drug discovery | RNA therapeutics.
What is Li Gan's email address?
Li Gan's email address is lg****@****isc.edu
What is Li Gan's direct phone number?
Li Gan's direct phone number is (617) 274*****
What schools did Li Gan attend?
Li Gan attended Und School Of Medicine & Health Sciences, Ocean University Of China, Ocean University Of China, West China Medical University (Sichuan University).
What are some of Li Gan's interests?
Li Gan has interest in Science And Technology, Children, Environment, Health.
What skills is Li Gan known for?
Li Gan has skills like Western Blotting, Neuroscience, Pharmacokinetics, Biochemistry, Neurodegeneration, Immunohistochemistry, Fluorescence Microscopy, Cell Culture, Molecular Biology, Cell Biology, Microscopy, Elisa.
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