Senior Staff Scientist, Head Of Cell Biology
CurrentTwist Biopharma • Lead multiple immune-oncology, immunology, infectious disease and GPCR projects for antibody drug discovery; Manage 2 scientists and 4 RAs. • Spearhead four major projects proceed to pre-clinical phase; One licensed out to world-leading pharma• Evaluate strategies and assay capabilities of revenue projects; Draft proposal and follow up financial milestone • Design, implement and manage in vitro mechanism of action validation assays with high throughput/automation or manual setup (e.g., Flow cytometry, ELISA, cell-based functional assays, primary immune cell assays, cytotoxicity assay, and immunogenicity assessments) • Effectively and timely communicate scientific interpretation to multi-disciplinary internal departments and external collaborators to deliver quality findings in support of drug candidate advancement• Critical scientific/technical data analysis, experiments interpretation, and report presentation• Establish team structure for lead characterization and stable cell line development workflow• Validate the potency of bispecific antibodies and secondary ADC cell binding, viability and cytotoxicity assay • Communicate with CRO for in vivo efficacy study, metabolic stability assay, PK study, toxicity study, and evaluate new partner collaboration • Listed in 5 patents as an inventor; 4 paper as an author; Presented in AACR, AAI and Keystone symposia as a speaker