Lisa Goldsmith

Lisa Goldsmith Email and Phone Number

Principal Engineer, Protein Process Development at Element Biosciences @ Element Biosciences
Lisa Goldsmith's Location
San Diego, California, United States, United States
Lisa Goldsmith's Contact Details
About Lisa Goldsmith

•Over 14 years experience and a broad range of skills in the expression, purification and characterization of recombinant proteins, peptides, and complex small molecules.•Represented employer as person-in-plant (PIP) and subject matter expert (SME) during purification process installation and batch production at CMO. Managed projects at CROs. •Managed purification team of 5 people. Trained and mentored junior scientific staff.•Independently design, lead, execute, optimize, and trouble-shoot scalable downstream processes for protein production.•Effective written and oral communication skills within a multi-disciplinary team.•Completed course in “Project Management Essentials in Science and Technology” (UCSD Extension, Winter, 2015)Selected skills:•Purification: AKTA (Avant, Pure, Pilot, Process); column packing and use (IEX, HIC, SEC, affinity and RP); solid phase extraction (Biotage), scalable process design and optimization using DOE; filtration (TFF), low endotoxin preps•Characterization and analysis: HPLC/ UPLC (RP, HILIC, SEC); SDS-PAGE, CE, Western Blot; Enzyme assays; Binding/ affinity (ELISA, Biacore, FACS); conjugation•Protein expression: Transient, and stable cell line generation•Mammalian cell culture and cell-based assays; sterile technique•General molecular cloning techniques

Lisa Goldsmith's Current Company Details
Element Biosciences

Element Biosciences

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Principal Engineer, Protein Process Development at Element Biosciences
Lisa Goldsmith Work Experience Details
  • Element Biosciences
    Principal Engineer, Protein Process Development
    Element Biosciences Jun 2022 - Present
    San Diego, California, Us
  • Synthorx Inc
    Principal Scientist
    Synthorx Inc Jun 2021 - Jun 2022
    La Jolla, Ca, Us
    Downstream, Protein Sciences
  • Synthorx Inc
    Senior Scientist
    Synthorx Inc Jan 2020 - Jun 2021
    La Jolla, Ca, Us
    Downstream, Early Stage CMC and Protein Sciences
  • La Jolla Pharmaceutical Company
    Senior Scientist
    La Jolla Pharmaceutical Company Sep 2017 - Dec 2019
    Waltham, Ma, Us
    -Developed a scalable purification process for a complex small molecule.-Tech transferred process to CMO. Acted as person-in-plant (PIP) and purification subject matter expert (SME) during process installation and batch manufacture.
  • Accelagen
    Senior Scientist
    Accelagen Jan 2016 - Aug 2017
    Us
  • Accelagen
    Research Scientist
    Accelagen Aug 2011 - Dec 2015
    Us
    -Developed purification processes and established characterization methods for an active pharmaceutical protein and an enzyme for the company’s product portfolio.-Generated detailed experiment protocols, presented results summaries to clients.
  • Fox Chase Cancer Center
    Postdoctoral Research Associate
    Fox Chase Cancer Center Sep 2008 - Apr 2011
    Philadelphia, Pa, Us
    -Designed, expressed, and evaluated bi-specific antibody-based therapeutics targeting breast, lung, and head and neck cancers.-Determined antibody binding epitopes and mechanisms of action.-Investigated in vitro combinations of bi-specific antibodies with standard of care treatments.
  • Ucla
    Graduate Student Researcher
    Ucla 2003 - 2008
    Los Angeles, Ca, Us
    -Developed protein nanocapsules for use as a targeted drug delivery system.-Used biochemical techniques to study protein conformational changes.-Actively loaded protein interiors with gold nanoparticles, His-tagged proteins, and small-molecule drugs conjugated to carrier proteins.
  • University Of California
    Teaching Experience
    University Of California 2003 - 2007
    Oakland, California, Us
    -Acted as mentor for two undergraduates and a high school student-Teaching assistant for Introduction to Chemical and Thermodynamics, Heat Transfer, and Chemical Engineering Laboratory
  • Ucla
    Research Assistant
    Ucla 2002 - 2002
    Los Angeles, Ca, Us
    -Characterized a tri-functional polypeptide in A. fulgidus using HPLC-MS

Lisa Goldsmith Skills

Protein Purification Protein Expression Protein Chemistry Western Blotting Molecular Cloning Sds Page Molecular Biology Pcr Biochemistry Elisa Cell Culture Biotechnology Immunoprecipitation Mammalian Cell Culture Dna Extraction Maldi Tof Site Directed Mutagenesis Rna Isolation Size Exclusion Protein Characterization Fluorescence Spectroscopy Bacterial Cell Culture Cell Signaling Akta Affinity Purification Light Scattering Protein Conjugation Protein Cross Linking Biacore Transient Transfection Cell Viability Assays Cellular Assays Facs Analysis Apoptosis Cell Cycle Analysis Pcr Primer Design Dna Electrophoresis Purification Process Development Problem Solving Troubleshooting Oral And Written Communication Skills

Lisa Goldsmith Education Details

  • Uc San Diego
    Uc San Diego
    Chemical Engineering
  • Ucla
    Ucla
    Chemical Engineering

Frequently Asked Questions about Lisa Goldsmith

What company does Lisa Goldsmith work for?

Lisa Goldsmith works for Element Biosciences

What is Lisa Goldsmith's role at the current company?

Lisa Goldsmith's current role is Principal Engineer, Protein Process Development at Element Biosciences.

What is Lisa Goldsmith's email address?

Lisa Goldsmith's email address is lg****@****orx.com

What is Lisa Goldsmith's direct phone number?

Lisa Goldsmith's direct phone number is +131070*****

What schools did Lisa Goldsmith attend?

Lisa Goldsmith attended Uc San Diego, Ucla.

What skills is Lisa Goldsmith known for?

Lisa Goldsmith has skills like Protein Purification, Protein Expression, Protein Chemistry, Western Blotting, Molecular Cloning, Sds Page, Molecular Biology, Pcr, Biochemistry, Elisa, Cell Culture, Biotechnology.

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