Lisa Goldsmith Email and Phone Number
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•Over 14 years experience and a broad range of skills in the expression, purification and characterization of recombinant proteins, peptides, and complex small molecules.•Represented employer as person-in-plant (PIP) and subject matter expert (SME) during purification process installation and batch production at CMO. Managed projects at CROs. •Managed purification team of 5 people. Trained and mentored junior scientific staff.•Independently design, lead, execute, optimize, and trouble-shoot scalable downstream processes for protein production.•Effective written and oral communication skills within a multi-disciplinary team.•Completed course in “Project Management Essentials in Science and Technology” (UCSD Extension, Winter, 2015)Selected skills:•Purification: AKTA (Avant, Pure, Pilot, Process); column packing and use (IEX, HIC, SEC, affinity and RP); solid phase extraction (Biotage), scalable process design and optimization using DOE; filtration (TFF), low endotoxin preps•Characterization and analysis: HPLC/ UPLC (RP, HILIC, SEC); SDS-PAGE, CE, Western Blot; Enzyme assays; Binding/ affinity (ELISA, Biacore, FACS); conjugation•Protein expression: Transient, and stable cell line generation•Mammalian cell culture and cell-based assays; sterile technique•General molecular cloning techniques
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Principal Engineer, Protein Process DevelopmentElement Biosciences Jun 2022 - PresentSan Diego, California, Us -
Principal ScientistSynthorx Inc Jun 2021 - Jun 2022La Jolla, Ca, UsDownstream, Protein Sciences -
Senior ScientistSynthorx Inc Jan 2020 - Jun 2021La Jolla, Ca, UsDownstream, Early Stage CMC and Protein Sciences -
Senior ScientistLa Jolla Pharmaceutical Company Sep 2017 - Dec 2019Waltham, Ma, Us-Developed a scalable purification process for a complex small molecule.-Tech transferred process to CMO. Acted as person-in-plant (PIP) and purification subject matter expert (SME) during process installation and batch manufacture. -
Senior ScientistAccelagen Jan 2016 - Aug 2017Us -
Research ScientistAccelagen Aug 2011 - Dec 2015Us-Developed purification processes and established characterization methods for an active pharmaceutical protein and an enzyme for the company’s product portfolio.-Generated detailed experiment protocols, presented results summaries to clients. -
Postdoctoral Research AssociateFox Chase Cancer Center Sep 2008 - Apr 2011Philadelphia, Pa, Us-Designed, expressed, and evaluated bi-specific antibody-based therapeutics targeting breast, lung, and head and neck cancers.-Determined antibody binding epitopes and mechanisms of action.-Investigated in vitro combinations of bi-specific antibodies with standard of care treatments. -
Graduate Student ResearcherUcla 2003 - 2008Los Angeles, Ca, Us-Developed protein nanocapsules for use as a targeted drug delivery system.-Used biochemical techniques to study protein conformational changes.-Actively loaded protein interiors with gold nanoparticles, His-tagged proteins, and small-molecule drugs conjugated to carrier proteins. -
Teaching ExperienceUniversity Of California 2003 - 2007Oakland, California, Us-Acted as mentor for two undergraduates and a high school student-Teaching assistant for Introduction to Chemical and Thermodynamics, Heat Transfer, and Chemical Engineering Laboratory -
Research AssistantUcla 2002 - 2002Los Angeles, Ca, Us-Characterized a tri-functional polypeptide in A. fulgidus using HPLC-MS
Lisa Goldsmith Skills
Lisa Goldsmith Education Details
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Uc San DiegoChemical Engineering -
UclaChemical Engineering
Frequently Asked Questions about Lisa Goldsmith
What company does Lisa Goldsmith work for?
Lisa Goldsmith works for Element Biosciences
What is Lisa Goldsmith's role at the current company?
Lisa Goldsmith's current role is Principal Engineer, Protein Process Development at Element Biosciences.
What is Lisa Goldsmith's email address?
Lisa Goldsmith's email address is lg****@****orx.com
What is Lisa Goldsmith's direct phone number?
Lisa Goldsmith's direct phone number is +131070*****
What schools did Lisa Goldsmith attend?
Lisa Goldsmith attended Uc San Diego, Ucla.
What skills is Lisa Goldsmith known for?
Lisa Goldsmith has skills like Protein Purification, Protein Expression, Protein Chemistry, Western Blotting, Molecular Cloning, Sds Page, Molecular Biology, Pcr, Biochemistry, Elisa, Cell Culture, Biotechnology.
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